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SPECC1

Official Full Name

sperm antigen with calponin homology and coiled-coil domains 1
Overview

The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms

SPECC1; sperm antigen with calponin homology and coiled-coil domains 1; cytospin-B; cytokinesis and spindle organization B; cytospin B; CYTSB; FLJ36955; HCMOGT 1; NSP; sperm antigen HCMOGT 1; NSP5; sperm antigen HCMOGT-1; structure protein NSP5a3a; struct;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SPECC1-240H	Recombinant Human SPECC1, His-tagged	E.coli	His	458-761aa	Inquiry
Mouse	Specc1-1957M	Recombinant Mouse Specc1 protein, His & T7-tagged	E.coli	His/T7	Gly961~Lys1063 (Accession # Q5SXY1)	Inquiry

SPECC1 Related Articles

SPECC1 involved in several pathways and played different roles in them. We selected most pathways SPECC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPECC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SPECC1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SPECC1 itself. We selected most functions SPECC1 had, and list some proteins which have the same functions with SPECC1. You can find most of the proteins on our site.

Function	Related Protein

SPECC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPECC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPECC1.

Kruszka, P; Li, D; et al. Mutations in SPECC1L, encoding sperm antigen with calponin homology and coiled-coil domains 1-like, are found in some cases of autosomal dominant Opitz G/BBB syndrome. JOURNAL OF MEDICAL GENETICS 52:104-110(2015).