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NSUN2

  • Official Full Name

    NOP2/Sun domain family, member 2

  • Overview

    This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
  • Synonyms

    NSUN2; NOP2/Sun domain family, member 2; NOL1/NOP2/Sun domain family 2 , NOL1/NOP2/Sun domain family, member 2; tRNA (cytosine(34)-C(5))-methyltransferase; FLJ20303; Misu; Myc induced SUN domain containing protein; TRM4; tRNA methyltransferase 4 homolog;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NSUN2-3684HCL Recombinant Human NSUN2 293 Cell Lysate HEK293 N/A
Human NSUN2-1126HFL Recombinant Full Length Human NSUN2 Protein, C-Flag-tagged Mammalian cells Flag
Human NSUN2-4967H Recombinant Human NSUN2 Protein (His415-Arg767), N-His tagged E.coli N-His His415-Arg767
Human NSUN2-1552H-B Recombinant Human NSUN2 Protein Pre-coupled Magnetic Beads HEK293
Human NSUN2-1552H Recombinant Human NSUN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NSUN2-10917M Recombinant Mouse NSUN2 Protein Mammalian Cell His
Mouse NSUN2-6224M Recombinant Mouse NSUN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NSUN2-6224M-B Recombinant Mouse NSUN2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Nsun2-4511M Recombinant Mouse Nsun2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish NSUN2-10107Z Recombinant Zebrafish NSUN2 Mammalian Cell His
Chicken NSUN2-2685C Recombinant Chicken NSUN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NSUN2 Related Articles

NSUN2 involved in several pathways and played different roles in them. We selected most pathways NSUN2 participated on our site, such as Aurora B signaling, Gene Expression, tRNA modification in the nucleus and cytosol, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSUN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aurora B signalingNDC80;CBX5;DES;PEBP1;SGOL1;TACC1;NCAPD2;AURKB;KIF20A
Gene ExpressionEIF2B1;EIF2C3;ZNF486;ZNF133;ZNF747;ZNF155;MBD3;KARS;AIMP2
tRNA modification in the nucleus and cytosolPUS7;TP53RK;MANEA;OSGEP;LCMT2;CCDC76;CDKAL1;TRDMT1;QTRT1
tRNA processingTP53RK;ZBTB8OS;ADAT2;TSEN2;TRMT11;KIAA1456;RPP40;POP7;FAM98B

NSUN2 has several biochemical functions, for example, poly(A) RNA binding, tRNA (cytosine-5-)-methyltransferase activity, tRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NSUN2 itself. We selected most functions NSUN2 had, and list some proteins which have the same functions with NSUN2. You can find most of the proteins on our site.

Function Related Protein
poly(A) RNA bindingZCCHC7;SPTBN1;GPATCH4;KIAA1324;WBP11;EFTUD2;ANKRD17;PURA;RPN1
tRNA (cytosine-5-)-methyltransferase activityMETTL21A;RNMTL1B;PRDM11;TRMT10C;METTL7B;METTL23;PRDM12;NSUN2;PRDM13
tRNA bindingDARS2;FDXACB1;FARSA;TRNT1;XPO5;PTCD1;XPOT;MADD;RARS

NSUN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSUN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NSUN2.

Cdk1; Tubg1; Plk1; Cep78; Dync1h1; argG; midostaurin; ssrna_ug; Srp72; NPM1; VCAM1

Martinez, FJ; Lee, JH; et al. Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome. JOURNAL OF MEDICAL GENETICS 49:380-385(2012).
Okamoto, M; Hirata, S; et al. Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers. DNA AND CELL BIOLOGY 31:660-671(2012).
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