NUDT4
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Official Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 4
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Overview
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. -
Synonyms
NUDT4; nudix (nucleoside diphosphate linked moiety X)-type motif 4; diphosphoinositol polyphosphate phosphohydrolase 2; diphosphoinositol polyphosphate phosphohydrolase type 2; DIPP2; DIPP2alpha; DIPP2beta; HDCMB47P; KIAA0487; Diadenosine 5 5 P1 P6 hexaphosphate hydrolase 2; DIPP 2; DKFZp686I1281; Nucleoside diphosphate linked moiety X motif 4; Nudix (nucleoside diphosphate linked moiety X) type motif 4; Nudix motif 4; Nudix type motif 4; NUDT 4; DIPP-2; OTTHUMP00000243079; OTTHUMP00000243080; OTTHUMP00000243082; OTTHUMP00000243083; OTTHUMP00000243084; diadenosine 5,5-P1,P6-hexaphosphate hydrolase 2; diphosphoinositol polyphosphate phosphohydrolase type;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | NUDT4-585H | Recombinant Human nudix (nucleoside diphosphate linked moiety X)-type motif 4, His-tagged | E.coli | His |
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| Human | NUDT4-3644HCL | Recombinant Human NUDT4 293 Cell Lysate | HEK293 | N/A |
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| Human | NUDT4-2144H | Recombinant Human NUDT4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Mouse | Nudt4-4542M | Recombinant Mouse Nudt4 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | NUDT4-4119R | Recombinant Rat NUDT4 Protein | Mammalian Cell | His |
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| Rat | NUDT4-3780R | Recombinant Rat NUDT4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | NUDT4-3780R-B | Recombinant Rat NUDT4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | NUDT4-3129R | Recombinant Rhesus monkey NUDT4 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | NUDT4-2947R | Recombinant Rhesus Macaque NUDT4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | NUDT4-2947R-B | Recombinant Rhesus Macaque NUDT4 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
NUDT4 involved in several pathways and played different roles in them. We selected most pathways NUDT4 participated on our site, such as Inositol phosphate metabolism, Metabolism, Synthesis of pyrophosphates in the cytosol, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PIP4K2B;IMPA1;SYNJ2;NUDT10;PIP4K2A;NUDT4A;TPI1B;PIK3CD;INPP4A |
| Metabolism | DPYS;GRX2;NUBP2;CYP27B1;HIBADHA;AKR1C4;MED6;OAZ2;MMADHC |
| Synthesis of pyrophosphates in the cytosol | NUDT4A;NUDT3A;NUDT4B;NUDT11;NUDT3B;NUDT10;IP6K3;NUDT3;NUDT4 |
NUDT4 has several biochemical functions, for example, diphosphoinositol-polyphosphate diphosphatase activity, inositol diphosphate tetrakisphosphate diphosphatase activity, inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT4 itself. We selected most functions NUDT4 had, and list some proteins which have the same functions with NUDT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| diphosphoinositol-polyphosphate diphosphatase activity | NUDT4;NUDT10;NUDT3;NUDT11 |
| inositol diphosphate tetrakisphosphate diphosphatase activity | NUDT11;NUDT3;NUDT4;NUDT10 |
| inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity | NUDT10;NUDT4;NUDT3;NUDT11 |
| inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity | NUDT10;NUDT4;NUDT3;NUDT11 |
| inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity | NUDT3;NUDT11;NUDT4;NUDT10 |
| inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity | NUDT3;NUDT11;NUDT4;NUDT10 |
| inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity | NUDT3;NUDT10;NUDT11;NUDT4 |
| inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity | NUDT3;NUDT11;NUDT4;NUDT10 |
| NOT m7G(5)pppN diphosphatase activity | NUDT5;NUDT1;NUDT7;NUDT4;NUDT16L1 |
| metal ion binding | HBAE1;NAIP1;MOB3A;BCL11AB;ZNF362B;SNRNP48;ZNF705A;C1GALT1A;ECE2 |
| protein binding | SPAST;IL33;BRK1;SYNE3;MYOZ2;STX7;IL6ST;Akap3;NCOA5 |
| snoRNA binding | NUDT5;HEATR1;IMP3;NOP14;NOP58;UTP15;NOP56;NUDT16;PWP2H |
NUDT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT4.
KEAP1; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate
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