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NUF2

  • Official Full Name

    NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

  • Overview

    Nuf2 is a component of kinetochore-associated Ndc80 complex which serves to attach microtubules to the kinetochore. Nuf2 is a conserved protein from yeast to human. Disruption of the Nuf2 gene in Schizosaccharomyces pombe causes defect in chromosome segregation and in the spindle checkpoint. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body and plays a regulatory role in chromosome segregation. In human cells Nuf2 specifically functions at kinetochores for stable microtubule attachment. Down regulation of the protein by RNA interference results in failure of the kinetochores to form attachments to the spindle microtubules. As a result cells are blocked in the prometaphase stage with an active spindle checkpoint and undergo cell death.
  • Synonyms

    NUF2; NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae); CDCA1, cell division cycle associated 1; kinetochore protein Nuf2; cancer/testis antigen 106; CT106; NUF2R; hNuf2; hNuf2R; hsNuf2; cell division cycle associated 1; cell division cycle-associated protein 1; CDCA1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NUF2-30416TH Recombinant Human NUF2, His-tagged E.coli His
Human NUF2-1320H Recombinant Human NUF2 Protein, GST-Tagged Wheat Germ GST
Human NUF2-3638HCL Recombinant Human NUF2 293 Cell Lysate HEK293 N/A
Human NUF2-3392HF Recombinant Full Length Human NUF2 Protein, GST-tagged In Vitro Cell Free System GST 464 amino acids
Mouse NUF2-10981M Recombinant Mouse NUF2 Protein Mammalian Cell His
Mouse NUF2-6264M-B Recombinant Mouse NUF2 Protein Pre-coupled Magnetic Beads HEK293
Mouse NUF2-6264M Recombinant Mouse NUF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NUF2-4123R Recombinant Rat NUF2 Protein Mammalian Cell His
Rat NUF2-3784R Recombinant Rat NUF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NUF2-3784R-B Recombinant Rat NUF2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NUF2-3133R Recombinant Rhesus monkey NUF2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NUF2-2951R-B Recombinant Rhesus Macaque NUF2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NUF2-2951R Recombinant Rhesus Macaque NUF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish NUF2-10639Z Recombinant Zebrafish NUF2 Mammalian Cell His
Chicken NUF2-6048C Recombinant Chicken NUF2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NUF2 Related Articles

NUF2 involved in several pathways and played different roles in them. We selected most pathways NUF2 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleDMC1;CDKN1BB;ANAPC2;SKA2;FGFR1OP;RBBP8;NCAPH;LIN54;KIF2C
Cell Cycle, MitoticKIF2B;ZWILCH;DHFR;SKA1;ACTR1A;SGOL1;CENPQ;NCAPH;CEP290
M PhaseTMEM188;VRK2;RANGAP1B;SKA1;SGOL2;ITGB3BP;PMF1;NEK7;NCAPG2
Mitotic AnaphaseCENPC1;CENPK;SKA1;CDCA8;PANE1;VRK1;CENPP;AHCTF1;SPDL1
Mitotic Metaphase and AnaphaseANKLE2;CENPP;CDCA5;INCENP;SKA2;CENPQ;NUF2;NUDC;ITGB3BP
Mitotic PrometaphaseNCAPG;CENPK;NDC80;CENPN;RANGAP1B;RCC2;DSN1;INCENP;PANE1
RHO GTPase EffectorsMIS12;ZWINT;CLIP1;SKA2;KIF14;SPDL1;SGOL2;ABI1;RHOGA
RHO GTPases Activate ForminsRANGAP1B;SGOL2;MIS12;FMNL2;KNTC1;RCC2;DSN1;ZW10;ZWINT

NUF2 has several biochemical functions, for example, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUF2 itself. We selected most functions NUF2 had, and list some proteins which have the same functions with NUF2. You can find most of the proteins on our site.

Function Related Protein
molecular_functionSOSTDC1A;CSMD1A;VMN1R130;SPG20B;PTCHD3;CHCHD6A;TMEM20;COL5A2;THADA
protein bindingZNF830;PEX19;SNRPB2;ICAM3;POLE4;NEDD8;EFHC1;SORT1;SNRPF

NUF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUF2.

NDC80; CENPE

Knowlton, AL; Vorozhko, VV; et al. ICIS and Aurora B Coregulate the Microtubule Depolymerase Kif2a. CURRENT BIOLOGY 19:758-763(2009).
Stucke, VM; Baumann, C; et al. Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. CHROMOSOMA 113:1-15(2004).
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