NAMPT
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Official Full Name
nicotinamide phosphoribosyltransferase
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Overview
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011] -
Synonyms
NAMPT; nicotinamide phosphoribosyltransferase; VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik; NAmPRTase; pre-B cell-enhancing factor; pre-B-cell colony enhancing factor 1; pre-B-cell colony-enhancing factor 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
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- E. coli
- E.coli
- HEK293
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- Insect Cell
- Insect Cells
- Mammalian Cell
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- Flag
- His
- His (Fc)
- Avi
- HA
- Myc
- N/A
- N
- GST
- Involved Pathway
- Protein Function
- Interacting Protein
- NAMPT Related Articles
- NAMPT Related Research Area
NAMPT involved in several pathways and played different roles in them. We selected most pathways NAMPT participated on our site, such as Adipogenesis, BMAL1:CLOCK,NPAS2 activates circadian gene expression, Circadian Clock, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAMPT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adipogenesis | BMP1;GATA2;GATA2A;KLF6A;PLIN2;GTF3AA;EPAS1B;CREB1;NR2F1 |
BMAL1:CLOCK,NPAS2 activates circadian gene expression | NAMPT;DBP;NCOA2;CREBBP;CRY2;CRY1;CARM1;NRIP1;HELZ2 |
Circadian Clock | CRY2;RAI1;HELZ2;DBP;NRIP1;CRY1;NAMPT;CARM1;CSNK1E |
Metabolic pathways | MT-ATP6;NDST1;CYP2A12;PTDSS2;ADC;DEGS1;PLCH2;PIPOX;MT-ND4 |
Metabolism | LYRM4;PAOX;ARSK;CERS4A;HS3ST6;CYP51A1;ALOX5B.3;MMS19;NOSIP |
Metabolism of vitamins and cofactors | KCNG4;PDZD11;CYB5A;CYB5R3;SLC2A3;TCN1;CTRC;NAMPT;MOCOS |
Metabolism of water-soluble vitamins and cofactors | SLC25A32;TCN1;SLC25A16;PDZD11;ELA2L;SLC19A2;CBLC-1;CTRB1;SLC23A2 |
NAD salvage |
NAMPT has several biochemical functions, for example, cytokine activity, drug binding, nicotinamide phosphoribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAMPT itself. We selected most functions NAMPT had, and list some proteins which have the same functions with NAMPT. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | TNFSF11;GDF11;CSF1A;IFNA2;IL10;MSTNB;SPAW;IFNA12;THPO |
drug binding | PPARA;HMGCS1;PDE4D;CHKA;SFRP1;DRD3;DHFR;PPARG;P2RX4 |
nicotinamide phosphoribosyltransferase activity | |
nicotinate-nucleotide diphosphorylase (carboxylating) activity | NAPRT;QPRT;NAMPT;KCNG4;NAMPTB;NAPRT1 |
protein binding | IFI30;FAM167A;RNF14;RAB7A;MNAT1;FLI1;MDFI;THOC7;PDCD2 |
protein homodimerization activity | PARK7;NRBP1;BNIP3;CAMK2G;LRRK2;RABEP1;NOG;KLHL7;CLIC6 |
NAMPT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAMPT here. Most of them are supplied by our site. Hope this information will be useful for your research of NAMPT.
FTL; MT-ND1; IFITM3; DDA1; UBE2L6; GGT1; ADORA2A; AKT2; sseA; dcyD
- Q&As
- Reviews
Q&As (6)
Ask a questionThe types of mutations in NAMPT include point mutations, insertions/deletions, duplications, etc., which can cause structural and functional abnormalities of the protein.
Some diseases related to NAD+ metabolism can be treated by regulating the level of NAMPT, such as by inhibiting its activity or regulating its expression.
Studying the regulatory mechanism of NAMPT requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
NAMPT has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.
NAMPT plays an important role in cellular energy metabolism by catalyzing the synthesis of NAD+, an important intracellular coenzyme involved in various reactions of energy metabolism.
Mutations in NAMPT can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
Customer Reviews (3)
Write a reviewDoes not trigger an immune response.
Methods such as ELISA or immunostaining perform well.
Easy to use, high stability, remarkable effect.
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