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NAMPT

  • Official Full Name

    nicotinamide phosphoribosyltransferase

  • Overview

    This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
  • Synonyms

    NAMPT; nicotinamide phosphoribosyltransferase; VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik; NAmPRTase; pre-B cell-enhancing factor; pre-B-cell colony enhancing factor 1; pre-B-cell colony-enhancing factor 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • CHO cells
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Yeast
  • Flag
  • His
  • His (Fc)
  • Avi
  • HA
  • Myc
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NAMPT-988H Active Recombinant Human NAMPT, Flag-tgged E.coli Flag
Human NAMPT-125H Recombinant Human NAMPT, Flag-tagged E.coli Flag
Human NAMPT-134H Recombinant Human Nicotinamide Phosphoribosyltransferase E.coli His
Human NAMPT-28520TH Recombinant Human NAMPT E.coli N/A
Human NAMPT-311H Recombinant Human NAMPT, His-tagged E.coli His
Human NAMPT-2168H Recombinant Human NAMPT, FLAG-tagged HEK293 Flag
Human NAMPT-23H Recombinant Human Visfatin, His-tagged E.coli His
Human NAMPT-2531H Recombinant Human NAMPT protein(Met1-His491), His&GST-tagged Insect Cells N-His&GST Met1-His491
Human NAMPT-905H Recombinant Human NAMPT Mammalian Cell His
Human NAMPT-491HCL Recombinant Human NAMPT cell lysate Insect Cell N/A
Human NAMPT-3579H-B Recombinant Human NAMPT Protein Pre-coupled Magnetic Beads HEK293
Human NAMPT-212H Recombinant Human NAMPT Protein E.coli
Human NAMPT-01H Active Recombinant Human NAMPT Protein, His-tagged E. coli His
Human NAMPT-2473H Recombinant Human NAMPT protein, His-tagged E.coli His 1-350 aa
Human NAMPT-3579H Recombinant Human NAMPT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NAMPT-3866H Recombinant Human NAMPT Protein (Met1-His491), N-His tagged E.coli N-His Met1-His491
Mouse Nampt-422M Recombinant Mouse Nampt, FLAG-tagged HEK293 Flag
Mouse NAMPT-10414M Recombinant Mouse NAMPT Protein Mammalian Cell His
Mouse Nampt-157M Recombinant Mouse Pre-B-cell Colony-enhancing Factor 1, His-tagged E.coli His
Mouse Nampt-1667M Recombinant Mouse Nicotinamide Phosphoribosyltransferase E.coli N/A
Mouse Nampt-4421M Recombinant Mouse Nampt protein, His&Myc-tagged E.coli His&Myc 1-491aa
Mouse Nampt-7402M Recombinant Mouse Nampt Protein, His-tagged E.coli His
Mouse Nampt-4423M Recombinant Mouse Nampt protein, His-tagged Yeast His 1-491aa
Mouse Nampt-4422M Recombinant Mouse Nampt protein E.coli N/A 1-491aa
Mouse NAMPT-5900M-B Recombinant Mouse NAMPT Protein Pre-coupled Magnetic Beads HEK293
Mouse Nampt-4420M Recombinant Mouse Nampt protein, His&HA-tagged E.coli His&HA 1-491aa(C39S)
Mouse Nampt-20MFL Recombinant Full Length Mouse Nampt Protein, N-Flag-tagged CHO cells N-Flag 1-491 aa
Mouse NAMPT-5900M Recombinant Mouse NAMPT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Nampt-383M Recombinant Mouse Nampt Protein, His-tagged E.coli N-His Met1-His491
Rat NAMPT-3895R Recombinant Rat NAMPT Protein Mammalian Cell His
Rat Nampt-1668R Recombinant Rat Nicotinamide Phosphoribosyltransferase E.coli N/A
Rat Nampt-649R Recombinant Rat Nampt protein, His-tagged E.coli His Met1~His491 (Accession # Q80Z29)
Rat Nampt-12RFL Recombinant Full Length Rat Nampt Protein, N-Flag-tagged HEK293T N-Flag 1-491 aa
Rat NAMPT-3554R-B Recombinant Rat NAMPT Protein Pre-coupled Magnetic Beads HEK293
Rat NAMPT-3554R Recombinant Rat NAMPT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit Nampt-2167R Recombinant Rat Nicotinamide Nhosphoribosyltransferase, FLAG-tagged HEK293 Flag
Pig NAMPT-3233P Recombinant Pig NAMPT protein, His-tagged E.coli His Met1~His491
Chicken NAMPT-2429C Recombinant Chicken NAMPT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NAMPT Related Articles
  • NAMPT Related Research Area

NAMPT involved in several pathways and played different roles in them. We selected most pathways NAMPT participated on our site, such as Adipogenesis, BMAL1:CLOCK,NPAS2 activates circadian gene expression, Circadian Clock, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAMPT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisBMP1;GATA2;GATA2A;KLF6A;PLIN2;GTF3AA;EPAS1B;CREB1;NR2F1
BMAL1:CLOCK,NPAS2 activates circadian gene expressionNAMPT;DBP;NCOA2;CREBBP;CRY2;CRY1;CARM1;NRIP1;HELZ2
Circadian ClockCRY2;RAI1;HELZ2;DBP;NRIP1;CRY1;NAMPT;CARM1;CSNK1E
Metabolic pathwaysMT-ATP6;NDST1;CYP2A12;PTDSS2;ADC;DEGS1;PLCH2;PIPOX;MT-ND4
MetabolismLYRM4;PAOX;ARSK;CERS4A;HS3ST6;CYP51A1;ALOX5B.3;MMS19;NOSIP
Metabolism of vitamins and cofactorsKCNG4;PDZD11;CYB5A;CYB5R3;SLC2A3;TCN1;CTRC;NAMPT;MOCOS
Metabolism of water-soluble vitamins and cofactorsSLC25A32;TCN1;SLC25A16;PDZD11;ELA2L;SLC19A2;CBLC-1;CTRB1;SLC23A2
NAD salvage

NAMPT has several biochemical functions, for example, cytokine activity, drug binding, nicotinamide phosphoribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAMPT itself. We selected most functions NAMPT had, and list some proteins which have the same functions with NAMPT. You can find most of the proteins on our site.

Function Related Protein
cytokine activityTNFSF11;GDF11;CSF1A;IFNA2;IL10;MSTNB;SPAW;IFNA12;THPO
drug bindingPPARA;HMGCS1;PDE4D;CHKA;SFRP1;DRD3;DHFR;PPARG;P2RX4
nicotinamide phosphoribosyltransferase activity
nicotinate-nucleotide diphosphorylase (carboxylating) activityNAPRT;QPRT;NAMPT;KCNG4;NAMPTB;NAPRT1
protein bindingIFI30;FAM167A;RNF14;RAB7A;MNAT1;FLI1;MDFI;THOC7;PDCD2
protein homodimerization activityPARK7;NRBP1;BNIP3;CAMK2G;LRRK2;RABEP1;NOG;KLHL7;CLIC6

NAMPT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAMPT here. Most of them are supplied by our site. Hope this information will be useful for your research of NAMPT.

FTL; MT-ND1; IFITM3; DDA1; UBE2L6; GGT1; ADORA2A; AKT2; sseA; dcyD

Jing, Z; Xing, J; et al. Neuronal NAMPT is released after cerebral ischemia and protects against white matter injury. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 34:1613-1621(2014).
Zhao, Y; Liu, XZ; et al. Extracellular Visfatin has Nicotinamide Phosphoribosyltransferase Enzymatic Activity and is Neuroprotective Against Ischemic Injury. CNS NEUROSCIENCE & THERAPEUTICS 20:539-547(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What are the mutation types of NAMPT? 11/19/2022

The types of mutations in NAMPT include point mutations, insertions/deletions, duplications, etc., which can cause structural and functional abnormalities of the protein.

How can diseases be treated by regulating NAMPT levels? 08/31/2022

Some diseases related to NAD+ metabolism can be treated by regulating the level of NAMPT, such as by inhibiting its activity or regulating its expression.

How to study the regulatory mechanism of NAMPT? 08/05/2022

Studying the regulatory mechanism of NAMPT requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What is the relationship of NAMPT to other genes or proteins? 07/04/2022

NAMPT has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

What is the specific role of NAMPT in cellular energy metabolism? 03/21/2022

NAMPT plays an important role in cellular energy metabolism by catalyzing the synthesis of NAD+, an important intracellular coenzyme involved in various reactions of energy metabolism.

How are mutations in NAMPT detected and analyzed? 12/01/2019

Mutations in NAMPT can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

Customer Reviews (3)

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Reviews
06/24/2022

    Does not trigger an immune response.

    12/14/2021

      Methods such as ELISA or immunostaining perform well.

      11/13/2021

        Easy to use, high stability, remarkable effect.

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