Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

NAT1

Official Full Name

N-acetyltransferase 1 (arylamine N-acetyltransferase)
Overview

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

NAT1; N-acetyltransferase 1 (arylamine N-acetyltransferase); AAC1; arylamine N-acetyltransferase 1; ARY1_HUMAN; Arylamide acetylase 1; Arylamine N acetyltransferase 1; MNAT; Monomorphic arylamine N acetyltransferase; Monomorphic arylamine N-acetyltransferase; N acetyltransferase type 1; N-acetyltransferase type 1; NAT 1; NAT-1; NATI; OTTHUMP00000122488; OTTHUMP00000224577; OTTHUMP00000224578; OTTHUMP00000224579;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
E.Coli or Yeast
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Fc
His
His (Fc)
Avi
N/A
N
GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NAT1-28863TH	Recombinant Human NAT1	Wheat Germ	N/A	290 amino acids	Inquiry
Human	NAT1-138H	Recombinant Human NAT1 Protein, His-tagged	E.coli	His		Inquiry
Human	NAT1-3573H	Recombinant Human NAT1, His-tagged	E.coli	His		Inquiry
Human	NAT1-30283TH	Recombinant Human NAT1, Fc-tagged	Wheat Germ	Fc	90 amino acids	Inquiry
Human	NAT1-30282TH	Recombinant Human NAT1, His-tagged	E.coli	His	290 amino acids	Inquiry
Human	NAT1-1168HCL	Recombinant Human NAT1 cell lysate		N/A		Inquiry
Human	NAT1-328HF	Recombinant Full Length Human NAT1 Protein	In Vitro Cell Free System		290 amino acids	Inquiry
Human	NAT1-1817H	Recombinant Human NAT1 Protein, His&GST-tagged	E.coli	N-His&GST	Asp20-Val280	Inquiry
Human	NAT1-2478H	Recombinant Human NAT1 Protein, His-tagged	E.coli	N-His	Asp20-Val280	Inquiry
Mouse	Nat1-3653M	Recombinant Mouse Nat1, His-tagged	E.Coli or Yeast	His	290	Inquiry
Mouse	NAT1-10434M	Recombinant Mouse NAT1 Protein	Mammalian Cell	His		Inquiry
Mouse	NAT1-5915M-B	Recombinant Mouse NAT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	NAT1-5915M	Recombinant Mouse NAT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Nat1-405M	Recombinant Mouse Nat1 Protein, His-tagged	E.coli	His	Arg9~Glu254	$298 / 10ug
Rat	NAT1-3906R	Recombinant Rat NAT1 Protein	Mammalian Cell	His		Inquiry
Rat	NAT1-3565R-B	Recombinant Rat NAT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	NAT1-3565R	Recombinant Rat NAT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NAT1 Related Articles

NAT1 involved in several pathways and played different roles in them. We selected most pathways NAT1 participated on our site, such as Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Caffeine metabolism	CYP2A6;NAT1;PNAT10;CYP1A2;Nat3;NAT;XDH;NAT2;UOX
Drug metabolism - other enzymes	UGT1A4;DPYDB;TYMP;XDH;Ces2e;DPYD;TK1;IMPDH1;GUSB
Metabolic pathways	ASPA;MTMR1A;SQLE;PCK2;AGPS;ADPGK;GOT2B;NDUFA4L;PGAM1
Chemical carcinogenesis	GSTM5;CYP2C18;SULT1A4;ALDH3B1;UGT2A2;CYP2C70;CYP3A5;ALDH1A3;CCBL1

NAT1 has several biochemical functions, for example, ATP binding, cyclin-dependent protein serine/threonine kinase activity, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAT1 itself. We selected most functions NAT1 had, and list some proteins which have the same functions with NAT1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	UBE2E2;PIP5KL1;PIK3CA;GUCY2E;RYK;CDK14;MVK;MAPK14;PAK2
cyclin-dependent protein serine/threonine kinase activity	CDK4;CDK3;CDKL4;CDKL3;CDK7;CDK14;CDK11A;CCND3;CDK8
protein kinase activity	HIPK3A;PIK3R4;WEE2;NEK4;GRK1A;PLK1;MMD2;PTK2AA;FGFR1B

NAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAT1.

LRRK2

Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).

Mikuls, TR; LeVan, T; et al. Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans. ARTHRITIS AND RHEUMATISM 64:655-664(2012).