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NAT2

  • Official Full Name

    N-acetyltransferase 2 (arylamine N-acetyltransferase)

  • Overview

    This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).
  • Synonyms

    NAT2; N-acetyltransferase 2 (arylamine N-acetyltransferase); AAC2; arylamine N-acetyltransferase 2; ARY2_HUMAN; Arylamide acetylase 2 (N-acetyltransferase 2, isoniazid inactivation); Arylamide acetylase 2; HGNC:7646; N-acetyltransferase type 2; NAT-2; PNAT; Polymorphic arylamine N-acetyltransferase; OTTHUMP00000161399; OTTHUMP00000224593;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NAT2-29721TH Recombinant Human NAT2 Wheat Germ N/A 290 amino acids
Human NAT2-1169HCL Recombinant Human NAT2 cell lysate N/A
Human NAT2-330HF Recombinant Full Length Human NAT2 Protein In Vitro Cell Free System 290 amino acids
Human NAT2-2061H Recombinant Human NAT2 Protein (1-290 aa), His-SUMO-tagged E.coli His/SUMO 1-290 aa
Mouse NAT2-10437M Recombinant Mouse NAT2 Protein Mammalian Cell His
Mouse Nat2-3654M Recombinant Mouse Nat2, His-tagged E.Coli or Yeast His 290
Mouse NAT2-5918M-B Recombinant Mouse NAT2 Protein Pre-coupled Magnetic Beads HEK293
Mouse NAT2-5918M Recombinant Mouse NAT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NAT2-3907R Recombinant Rat NAT2 Protein Mammalian Cell His
Rat NAT2-406R Recombinant Rat Nat2 Protein, His/GST-tagged E.coli His/GST Asp20~Val280
Rat NAT2-3566R-B Recombinant Rat NAT2 Protein Pre-coupled Magnetic Beads HEK293
Rat NAT2-3566R Recombinant Rat NAT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NAT2-2949R Recombinant Rhesus monkey NAT2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NAT2-2769R-B Recombinant Rhesus Macaque NAT2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NAT2-2769R Recombinant Rhesus Macaque NAT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NAT2 Related Articles

NAT2 involved in several pathways and played different roles in them. We selected most pathways NAT2 participated on our site, such as Acetylation, Arylamine metabolism, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acetylation
Arylamine metabolismCYP1A2;NAT2
Biological oxidationsSLC26A2;AADAC;UGT1B3;CYP7A1;CYP2U1;GSTK1;CYP2Y3;SULT1C2;CYP2AD6
Caffeine metabolismNAT;CYP2A6;Nat3;NAT1;PNAT3;PNAT10;XDH;UOX;CYP1A2
Chemical carcinogenesisAKR1C2;GSTA1;MGST1;ADH1B;CYP2C8;ALDH3B2;CHRNA7;UGT1A6B;ARNT
Drug metabolism - other enzymesUGT2B15;NAT1;UGT2A1;UGT1A6B;UGT2A2;UGT1A9;TK2;PNAT3;GMPS
Metabolic pathwaysG6PC;B3GALNT1;INPP5A;LDHC;GBE1;ALG8;PLCD4;PCCA;NAT
MetabolismCPNE3;ARSH;CYP2K6;ACOT10;AK7A;CKMB;AKR1C4;GCHFR;LPA

NAT2 has several biochemical functions, for example, arylamine N-acetyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NAT2 itself. We selected most functions NAT2 had, and list some proteins which have the same functions with NAT2. You can find most of the proteins on our site.

Function Related Protein
arylamine N-acetyltransferase activityNAT;Nat3;PNAT3;PNAT10;AANAT;NAT2
protein bindingPRPF40A;BMP1A;RASSF4;RPS15;CCAR1;MYOZ1;CTLA2B;GBA;EPB41L1

NAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAT2.

RAD51; ATM; AURKA; PPM1D; NBN; HMMR; BAG4; ERBB2; IGF1R; CDH1; WT1; APC; CDKN2A; CDKN2C; STK11; PALB2

Mikuls, TR; LeVan, T; et al. Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans. ARTHRITIS AND RHEUMATISM 64:655-664(2012).
Littorin, M; Hou, S; et al. Influence of polymorphic metabolic enzymes on biotransformation and effects of diphenylmethane diisocyanate. INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 81:429-441(2008).
  • Q&As
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