NAT2
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Official Full Name
N-acetyltransferase 2 (arylamine N-acetyltransferase)
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Overview
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). -
Synonyms
NAT2; N-acetyltransferase 2 (arylamine N-acetyltransferase); AAC2; arylamine N-acetyltransferase 2; ARY2_HUMAN; Arylamide acetylase 2 (N-acetyltransferase 2, isoniazid inactivation); Arylamide acetylase 2; HGNC:7646; N-acetyltransferase type 2; NAT-2; PNAT; Polymorphic arylamine N-acetyltransferase; OTTHUMP00000161399; OTTHUMP00000224593;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- His|GST
- His|SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- NAT2 Related Articles
NAT2 involved in several pathways and played different roles in them. We selected most pathways NAT2 participated on our site, such as Acetylation, Arylamine metabolism, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Acetylation | |
Arylamine metabolism | CYP1A2;NAT2 |
Biological oxidations | SLC26A2;AADAC;UGT1B3;CYP7A1;CYP2U1;GSTK1;CYP2Y3;SULT1C2;CYP2AD6 |
Caffeine metabolism | NAT;CYP2A6;Nat3;NAT1;PNAT3;PNAT10;XDH;UOX;CYP1A2 |
Chemical carcinogenesis | AKR1C2;GSTA1;MGST1;ADH1B;CYP2C8;ALDH3B2;CHRNA7;UGT1A6B;ARNT |
Drug metabolism - other enzymes | UGT2B15;NAT1;UGT2A1;UGT1A6B;UGT2A2;UGT1A9;TK2;PNAT3;GMPS |
Metabolic pathways | G6PC;B3GALNT1;INPP5A;LDHC;GBE1;ALG8;PLCD4;PCCA;NAT |
Metabolism | CPNE3;ARSH;CYP2K6;ACOT10;AK7A;CKMB;AKR1C4;GCHFR;LPA |
NAT2 has several biochemical functions, for example, arylamine N-acetyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NAT2 itself. We selected most functions NAT2 had, and list some proteins which have the same functions with NAT2. You can find most of the proteins on our site.
Function | Related Protein |
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arylamine N-acetyltransferase activity | NAT;Nat3;PNAT3;PNAT10;AANAT;NAT2 |
protein binding | PRPF40A;BMP1A;RASSF4;RPS15;CCAR1;MYOZ1;CTLA2B;GBA;EPB41L1 |
NAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAT2.
RAD51; ATM; AURKA; PPM1D; NBN; HMMR; BAG4; ERBB2; IGF1R; CDH1; WT1; APC; CDKN2A; CDKN2C; STK11; PALB2
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