ncf1
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  • Official Full Name
  • neutrophil cytosolic factor 1
  • Background
  • The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a;multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with;chronic granulomatous disease.
  • Synonyms
  • NCF1; neutrophil cytosolic factor 1; neutrophil cytosolic factor 1 (47kD, chronic granulomatous disease, autosomal 1); neutrophil cytosol factor 1; chronic granulomatous disease; autosomal 1; NADPH oxidase organizer 2; NCF1A; NOXO2; p47phox; SH3PXD1A; NCF-1; NCF-47K; p47-phox; nox organizer 2; nox-organizing protein 2; 47 kDa neutrophil oxidase factor; neutrophil NADPH oxidase factor 1; SH3 and PX domain-containing protein 1A; 47 kDa autosomal chronic granulomatous disease protein; neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); FLJ79451
Cat.#:NCF1-2749HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Neutrophil Cytosolic Factor 1, His-tagged
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Cat.#:NCF1-1721HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Neutrophil Cytosolic Factor 1, His-tagged
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Cat.#:NCF1-1208HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NCF1, His-tagged
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Cat.#:NCF1-10467MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NCF1 Protein
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Cat.#:NCF1-2411CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NCF1
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Cat.#:NCF1-3211ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NCF1
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Cat.#:NCF1-3950HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NCF1 293 Cell Lysate
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Involved Pathway

NCF1 involved in several pathways and played different roles in them. We selected most pathways NCF1 participated on our site, such as Chemokine signaling pathway, Phagosome, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
GNB1; CCL2; PLCB4; HCK; CCL3; Ccl27a; RAF1; GNG12; ADRBK1; PTK2B
Phagosome
SEC61A1; CTSLA; FCAR; C3A.3; TUBA8L; RILP; CLEC4M; TUBA3D; ATP6V0A2B; HLA-E
Osteoclast differentiation
MAP2K1; IL1B; NFKB1; FCGR1A; STAT1; ACP5; MAPK8; OSCAR; MAP3K7; CSF1R
Fc gamma R-mediated phagocytosis
PPAP2A; FCGR2B; ARPC5L; MARCKS; SYK; PPAP2C; PIP5K1A; PLD1; LAT; MYO10
Leukocyte transendothelial migration
ACTN2; CLDN22; CLDN8; CDH5; NIPAL1; PIK3R3; JAM3; NOX1; PTK2B; PIK3R5
Leishmaniasis
NFKBIB; PTPN6; IL4; TRAF6; MYD88; MAPK3; IL12A; NFKBIA; H2-AB1; MARCKSL1

Protein Function

NCF1 has several biochemical functions, for example, SH3 domain binding, electron carrier activity, phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCF1 itself. We selected most functions NCF1 had, and list some proteins which have the same functions with NCF1. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein EFS; RAD9A; LYN; PTTG1; GRIK5; ELMO2; UVRAG; ARHGAP1; REPS1; SH3BP5L
Function electron carrier activity
Related Protein AKR1A1; QDPR; AOX1; POR; FDX1; FDX1L; TXNRD3; ACAD8; PHGDH; GRXCR1
Function phosphatidylinositol binding
Related Protein SNX12; NCF1; TULP3; SNX1A; RPS6KC1; SNX18A; SNX4; SNX7; PIK3C2A; PXK
Function phosphatidylinositol-3,4-bisphosphate binding
Related Protein ADAP2; ARAP3; KIF16B; ZFYVE1; ANXA8; MYO1G; FAM21C; PLEKHA1; PLEK; RS1
Function protein binding
Related Protein TMEM66; THBS1; KLHDC5; FMR1; TPM1; CYTH3; TSR2; CINP; NUDT12; FRK
Function superoxide-generating NADPH oxidase activity
Related Protein NCF1; NOX5; NOX4; PAX2; NOX3; SH3PXD2AA; CYBB; NOX1

Interacting Protein

NCF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCF1.
NCF2; CYBA; RELA

NCF1 Related Articles

Pizzolla, A; Wing, K; et al. A Glucose-6-Phosphate Isomerase Peptide Induces T and B Cell-Dependent Chronic Arthritis in C57BL/10 Mice Arthritis without Reactive Oxygen Species and Complement. AMERICAN JOURNAL OF PATHOLOGY 183:1144-1155(2013).
Savchenko, VL; et al. Regulation of NADPH Oxidase Gene Expression with PKA and Cytokine IL-4 in Neurons and Microglia. NEUROTOXICITY RESEARCH 23:201-213(2013).