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NCF1

  • Official Full Name

    neutrophil cytosolic factor 1

  • Overview

    The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a;multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with;chronic granulomatous disease.
  • Synonyms

    NCF1; neutrophil cytosolic factor 1; neutrophil cytosolic factor 1 (47kD, chronic granulomatous disease, autosomal 1); neutrophil cytosol factor 1; chronic granulomatous disease; autosomal 1; NADPH oxidase organizer 2; NCF1A; NOXO2; p47phox; SH3PXD1A; NCF-1; NCF-47K; p47-phox; nox organizer 2; nox-organizing protein 2; 47 kDa neutrophil oxidase factor; neutrophil NADPH oxidase factor 1; SH3 and PX domain-containing protein 1A; 47 kDa autosomal chronic granulomatous disease protein; neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); FLJ79451;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NCF1-1208H Recombinant Human NCF1, His-tagged E.coli His 201-390aa
Human NCF1-1721H Recombinant Human Neutrophil Cytosolic Factor 1, His-tagged Human His
Human NCF1-2749H Recombinant Human Neutrophil Cytosolic Factor 1, His-tagged E.coli His
Human NCF1-3950HCL Recombinant Human NCF1 293 Cell Lysate HEK293 N/A
Human NCF1-1485H Recombinant Human NCF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NCF1-576HFL Active Recombinant Full Length Human NCF1 Protein, C-Flag-tagged Mammalian cells Flag
Human NCF1-2411H Recombinant Human NCF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NCF1-5111H Recombinant Human NCF1 Protein (Met1-Val390) E.coli Tag Free Met1-Val390
Human NCF1-1485H-B Recombinant Human NCF1 Protein Pre-coupled Magnetic Beads HEK293
Human NCF1-301532H Recombinant Human NCF1 protein, GST-tagged E.coli GST Lys31-Glu190
Human NCF1-5112H Recombinant Human NCF1 Protein (Met1-Val390), N-His tagged E.coli N-His Met1-Val390
Mouse NCF1-10467M Recombinant Mouse NCF1 Protein Mammalian Cell His
Mouse Ncf1-4308M Recombinant Mouse Ncf1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NCF1-5937M Recombinant Mouse NCF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NCF1-5937M-B Recombinant Mouse NCF1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NCF1-3211Z Recombinant Zebrafish NCF1 Mammalian Cell His
Chicken NCF1-2411C Recombinant Chicken NCF1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NCF1 Related Articles

NCF1 involved in several pathways and played different roles in them. We selected most pathways NCF1 participated on our site, such as Chemokine signaling pathway, Phagosome, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayCxcl15;CCR7;ADRBK2;CCL27;HRAS;CCL6;PRKCB;GM2506;CXCR5
PhagosomeATP6V0CA;CLEC4M;ATP6AP1;TUBA3C;RAB5C;C3;ITGAV;FCGR2B;ATP6V1C2
Osteoclast differentiationPPARG;IKBKG;FYN;TRAF6;TYK2;TAB2;PIK3R1;cgr2b;FCGR3
Fc gamma R-mediated phagocytosisHCK;MAP2K1;ARPC1A;PRKCA;AKT1;WASL;SPHK2;VAV3;AKT2
Leukocyte transendothelial migrationPIK3CG;AASS;CYBB;ACTG1;CLDN8;CLDN23;PTK2B;THY1;RAC1
LeishmaniasisTGFB1;IL1A;FCGR3A;FCGR4;FCGR2A;HLA-DQA2;TGFB2;TLR2;FCGR3B

NCF1 has several biochemical functions, for example, SH3 domain binding, electron carrier activity, phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCF1 itself. We selected most functions NCF1 had, and list some proteins which have the same functions with NCF1. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingSH3BP5LA;ELMO3;SH3BP5L;ITM2B;ARHGAP6;CBLC;REPS1;CASP9;PTPN12
electron carrier activityGLRX2;ACADL;ACADSB;ACAD8;TXNRD1;AOX3L1;ACAD11;PTGESL;TSTA3
phosphatidylinositol bindingSNX10A;SNX9A;AKR1C1;SNX22;SH3PXD2A;SNX27A;SNX13;SNX29;ITPR1
phosphatidylinositol-3,4-bisphosphate bindingRS1;GAB2;AKT1;PLEKHA1;RAG2;MAPKAP1;ZFYVE1;D6WSU116E;ARAP3
protein bindingHYI;VAPB;HDAC3;SOCS3;BID;ITGB1BP3;ACVRL1;MEAF6;C11orf68
superoxide-generating NADPH oxidase activityNOX3;SH3PXD2AA;CYBB;NOX5;NCF1;NOX1;PAX2;NOX4

NCF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCF1.

NCF2; CYBA; RELA

Pizzolla, A; Wing, K; et al. A Glucose-6-Phosphate Isomerase Peptide Induces T and B Cell-Dependent Chronic Arthritis in C57BL/10 Mice Arthritis without Reactive Oxygen Species and Complement. AMERICAN JOURNAL OF PATHOLOGY 183:1144-1155(2013).
Savchenko, VL; et al. Regulation of NADPH Oxidase Gene Expression with PKA and Cytokine IL-4 in Neurons and Microglia. NEUROTOXICITY RESEARCH 23:201-213(2013).
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