NCL
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Official Full Name
nucleolin
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Overview
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008] -
Synonyms
NCL; nucleolin; C23;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Fc
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- mFc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- NCL Related Articles
NCL involved in several pathways and played different roles in them. We selected most pathways NCL participated on our site, such as Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathogenic Escherichia coli infection | CD14;TUBA8;TUBAL3;TUBA3E;TLR5;TUBB2B;TUBA1B;KRT18;PRKCA |
NCL has several biochemical functions, for example, ErbB-4 class receptor binding, RNA binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCL itself. We selected most functions NCL had, and list some proteins which have the same functions with NCL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ErbB-4 class receptor binding | |
| RNA binding | RBM23;HNRPL;SFSWAP;CELF3;APOBEC3F;RPL21;RBM44;RBM8A;ZMAT4 |
| calcium ion binding | SRR;SPARC;S100A11;MEX3B;SLC25A24;SLIT3;NOTCH2;EFHD1;MYL1 |
| histone binding | WDTC1;HIST1H4F;NFKBIL2;CTCFL;JAK2;USP3;ELP2;NOC2L;UHRF2 |
| identical protein binding | VWA1;TRIM23;ZNF212;SMN2;PRKAB2;SCAND1;SFRP1;DDX58;RIPK1 |
| laminin binding | LRRC15;CTSS;LYPD5;LGALS3;BCAM;LGALS1;NCL;TINAGL1;GPC1 |
| nucleotide binding | CKMT1;RBFOX2;SEPT7B;RBMX2;ABCG2D;MYHC4;RHOGD;RND3A;HSC70 |
| poly(A) RNA binding | ADARB1;RPS5;RBM7;SRP54B;NUDT21;HSPE1;SFPQ;HIST1H4K;PPIG |
| protein C-terminus binding | TJP2;ERCC6;NCL;VGLL3;CLIC6;HIC2;HOMER3;MAP3K7;PPP2CB |
| protein binding | PDGFC;EIF3F;CD63;CLDN1;AJUBA;CSRP3;TNNI3K;RPP25;AGT |
| rRNA primary transcript binding | NCL;IMP4;RPF1;PTRF |
| selenocysteine insertion sequence binding | NCL;SECISBP2 |
| single-stranded DNA binding | NABP1;PMS1;NABP1A;NEIL3;SSBP4;PCBP1;TTC6;SWSAP1;SSBP3A |
| telomeric DNA binding | TINF2;TEN1;TERFA;NCL;HNRNPD;PIF1;CTC1;TP53BP1;TERF2 |
NCL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCL here. Most of them are supplied by our site. Hope this information will be useful for your research of NCL.
COL18A1; MDM2
- Q&As
- Reviews
Q&As (5)
Ask a questionNCL is mainly localized in the nucleus.
NCL is closely related to the study of diseases such as nasopharyngeal cancer and endometrial cancer.
The NCL consists of three parts: a nuclear localization signal, an RNA binding domain, and RGG or GAR structural domains.
Overexpression of NCL increases PCV2 viral load in cells.
NCL is involved in the regulation of various physiological stages such as cell proliferation, differentiation, and embryogenesis.
Customer Reviews (3)
Write a reviewThe company provides one-stop service, from the purchase of products to the completion of experiments in one go.
The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.
The staff had a good attitude, actively communicated with me and solved many technical problems.
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