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NRP1

  • Official Full Name

    neuropilin 1

  • Overview

    This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms

    NRP1; neuropilin 1; NP1; NRP; BDCA4; CD304; VEGF165R; neuropilin-1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • Fc
  • hFc
  • His
  • Avi
  • mFc
  • Fc|His
  • His (Fc)
  • His|GST
  • His|MBP
  • human|IgG1|Fc
  • Mouse|IgG2a|Fc
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NRP1-644H Active Recombinant Human NRP1 protein(Met1-Lys644), His-tagged HEK293 C-His Met1-Lys644
Human NRP1-090H Active Recombinant Human NRP1 Protein(Met 1-Lys 644, with natural variants V179A), His-tagged HEK293 His Met 1-Lys 644, with natural variants V179A
Human NRP1-1365H Acitve Recombinant Human NRP1 protein(Met1-Lys644), His&Avi-tagged, Biotinylated HEK293 C-His&Avi Met1-Lys644
Human NRP1-803H Recombinant Human NRP1 protein, His-tagged E.coli His Tyr646~Asp814 (Accession # O14786)
Human NRP1-3346H Recombinant Human NRP1 protein, Fc-tagged HEK293 human/IgG1/Fc Phe22-Lys644
Human NRP1-804H Recombinant Human NRP1 protein, His-tagged E.coli His Cys27~Arg143 (Accession # O14786)
Human NRP1-1763HCL Recombinant Human NRP1 cell lysate Human Cell N/A
Human NRP1-806H Recombinant Human NRP1 protein, His-tagged E.coli His
Human NRP1-396H Recombinant Human NRP1 Protein, His-tagged HEK293 His 923
Human NRP1-1321H Recombinant Human NRP1 Protein (Lys274-Glu584), N-His tagged E.coli N-His Lys274-Glu584
Human NRP1-3684H Recombinant Human NRP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NRP1-0566H Active Recombinant Human NRP1 protein, Fc-tagged HEK293 Fc Phe22-Lys644
Human NRP1-3684H-B Recombinant Human NRP1 Protein Pre-coupled Magnetic Beads HEK293
Human NRP1-3752H Recombinant Human NRP1 Protein (Met1-Lys644), C-Fc tagged Mammalian cells C-Fc Met1-Lys644
Human NRP1-2512H Recombinant Human NRP1 Protein, His-tagged E.coli N-His Cys27-Asp444
Human NRP1-2644H Recombinant Human NRP1 Protein (Phe22-Lys644), His tagged E.coli His Phe22-Lys644
Human NRP1-5255H Recombinant Human NRP1 Protein (Phe22-Lys644), C-His tagged Mammalian cells C-His Phe22-Lys644
Human NRP1-5254H Recombinant Human NRP1 Protein (Met1-Lys644), C-His tagged Mammalian cells C-His Met1-Lys644
Human NRP1-1322H Recombinant Human NRP1 Protein (Phe22-Ser641), N-His tagged E.coli N-His Phe22-Ser641
Human NRP1-2065H Recombinant Human NRP1 protein, His-tagged HEK293 His Phe22-Lys644
Human NRP1-8119H Active Recombinant Human NRP1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Phe 22 - Lys 644
Human NRP1-5594H Recombinant Human NRP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NRP1-805H Recombinant Human NRP1 protein, His-tagged E.coli His Cys27-Asp444
Human NRP1-3347H Active Recombinant Human NRP1 protein, mFc-tagged HEK293 mFc Phe 22 - Lys 644
Human NRP1-159H Recombinant Human NRP1 Protein, His-tagged E.coli His
Human NRP1-1159H Recombinant Human NRP1 Protein, His-tagged HEK293F N-His Cys27-Asp444
Human NRP1-397H Recombinant Human NRP1 Protein, Fc-tagged HEK293 Fc 923
Mouse Nrp1-613M Active Recombinant Mouse Nrp1 Protein, His-tagged Mammalian cells His Phe22-Pro856
Mouse Nrp1-807M Recombinant Mouse Nrp1 protein, His-tagged E.coli His Cys275~Cys424 (Accession # P97333)
Mouse Nrp1-805M Recombinant Mouse Nrp1 protein, His-tagged E.coli His Cys27~Phe141 (Accession # P97333)
Mouse NRP1-10898M Recombinant Mouse NRP1 Protein Mammalian Cell His
Mouse Nrp1-808M Recombinant Mouse Nrp1 protein, His-tagged E.coli His Cys431~Cys583 (Accession # P97333)
Mouse Nrp1-806M Recombinant Mouse Nrp1 protein, His-tagged E.coli His Cys147~Leu265 (Accession # P97333)
Mouse NRP1-329M Recombinant Mouse NRP1 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc 835
Mouse Nrp1-4502M Recombinant Mouse Nrp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Nrp1-8118M Active Recombinant Mouse Nrp1 protein(Met1-Pro856), mFc-tagged HEK293 C-mFc Met1-Pro856
Mouse NRP1-680M Active Recombinant Mouse NRP1 protein, mFc-tagged HEK293 mFc Phe 22 - Pro 856
Mouse NRP1-0565M Active Recombinant Mouse NRP1 protein(Phe22-Pro856), His-tagged HEK293 C-His Phe22-Pro856
Mouse NRP1-6210M Recombinant Mouse NRP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NRP1-6210M-B Recombinant Mouse NRP1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Nrp1-6211M Recombinant Mouse Nrp1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Nrp1-6211M-B Recombinant Mouse Nrp1 Protein Pre-coupled Magnetic Beads HEK293
Rat NRP1-4084R Recombinant Rat NRP1 Protein Mammalian Cell His
Rat Nrp1-810R Recombinant Rat Nrp1 protein, His-tagged E.coli His Asn150~Val264 (Accession # Q9QWJ9)
Rat Nrp1-812R Recombinant Rat Nrp1 protein, His & MBP-tagged E.coli His/MBP Cys27~Thr152 (Accession # Q9QWJ9)
Rat Nrp1-809R Recombinant Rat Nrp1 protein, His-tagged E.coli His Thr645~Glu821 (Accession # Q9QWJ9)
Rat Nrp1-811R Recombinant Rat Nrp1 protein, His & GST-tagged E.coli His/GST Cys27~Thr152 (Accession # Q9QWJ9)
Rat NRP1-3743R Recombinant Rat NRP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NRP1-3743R-B Recombinant Rat NRP1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus NRP1-1218C Active Recombinant Cynomolgus NRP1 protein(Met1-Gly613), His-tagged HEK293 C-His Met1-Gly613
Cynomolgus NRP1-1290C Acitve Recombinant Cynomolgus NRP1 protein(Met1-Gly613), hFc-tagged HEK293 C-hFc Met1-Gly613
Cynomolgus NRP1-1219C Active Recombinant Cynomolgus NRP1 protein HEK293 N/A Met1-Gly613
Cynomolgus Monkey NRP1-157C Recombinant Cynomolgus NRP1, Fc tagged Human Cell Fc/His
Cynomolgus Monkey NRP1-158C Recombinant Cynomolgus NRP1, LEVLFQ tagged Human Cell His
Cynomolgus Monkey NRP1-811CCL Recombinant Cynomolgus NRP1 cell lysate Human Cell N/A
Rhesus Macaque NRP1-3104R Recombinant Rhesus monkey NRP1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NRP1-2923R Recombinant Rhesus Macaque NRP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NRP1-2923R-B Recombinant Rhesus Macaque NRP1 Protein Pre-coupled Magnetic Beads HEK293
Chicken NRP1-6346C Recombinant Chicken NRP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NRP1 Related Articles

NRP1 involved in several pathways and played different roles in them. We selected most pathways NRP1 participated on our site, such as Axon guidance, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidancePPP3CB;EPHA6;ARPC5;EFNB3;EFNA3;FRS3;UNC5C;AP2A2;LAMTOR2
HTLV-I infectionCDC23;HLA-DRB4;MAPK8;PDGFRA;VDAC2;TRP53;DVL2;FZD5;APC

NRP1 has several biochemical functions, for example, coreceptor activity, cytokine binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRP1 itself. We selected most functions NRP1 had, and list some proteins which have the same functions with NRP1. You can find most of the proteins on our site.

Function Related Protein
coreceptor activityCXCR4;RGMD;IGSF1;PVRL1;TMIGD2;ACKR3B;PVRL2;CCR5;ACVR2A
cytokine bindingCD74;CNTFR;NOG;PARK7;ELANE;IL17F;Fzd4;CSF1R;CSF1RA
growth factor bindingLIFR;FGFBP2;A2M;RHBDF1;HTRA1A;RHBDF2;RPL37;NRP2;GHR
heparin bindingLIPC;SLIT2;CXCL11;ADAMTS1;RPL22;LXN;TENM1;COMP;ZFP207
metal ion bindingEXT1B;MAT2AA;EXTL2;KLK4;ZNF550;NUBP1;Scd1;ZNF584;ZBTB12.1
protein bindingMUSK;C12orf49;RNF6;JUND;OSTB;TRIM38;FAM133A;PYCRL;COG4
semaphorin receptor activityPLXNA1;PLXNB2;PLXNA1B;NRP2;PLXNA3;NRP2A;NRP1;PLXNC1;PLXNB2A
vascular endothelial growth factor bindingPDGFRA;PDGFRB;KDR;NRP1
vascular endothelial growth factor-activated receptor activityFLT3;NRP2B;NRP2A;NRP2;NRP1;KDR;FLT4;PDGFRA;NRP1B

NRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRP1.

VEGFA; KDR; FLNA; FLT1; RPL27; ptsN1; CSNK2A2

Weekes, CD; Beeram, M; et al. A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors. INVESTIGATIONAL NEW DRUGS 32:653-660(2014).
Venkova, K; Christov, A; et al. Semaphorin 3A Signaling Through Neuropilin-1 Is an Early Trigger for Distal Axonopathy in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 73:702-713(2014).
  • Q&As
  • Reviews

Q&As (6)

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What is the role of NRP1 in lung disease? 12/01/2022

It may be involved in the processes of angiography, inflammation, fibrosis and other processes in the lungs, and is related to the occurrence and development of lung diseases.

What factors are associated with high NRP1 expression? 01/02/2022

The high expression of NRP1 may be related to factors such as the aggressiveness of the tumor and the increased angiogenesis of the tumor.

Can NRP1 be targeted for targeted therapy? 03/02/2021

Yes, NRP1, as a molecule with important biological functions and clinical significance, can be targeted as a target therapy.

What are the applications of NRP1 in clinical diagnosis? 10/29/2020

This protein can be used as a potential marker in clinical diagnosis for tumor diagnosis and prognosis evaluation.

Is NRP1 associated with drug therapy? 04/18/2020

Yes, NRP1 may be related to the metabolism of drugs, the response to drug treatment, etc., which affects the efficacy and side effects of drugs.

How is NRP1 related to immune diseases? 04/07/2020

NRP1 may be involved in the regulation of autoimmune responses, inflammatory responses, etc., and is related to the occurrence and development of immune diseases.

Customer Reviews (3)

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Reviews
05/24/2022

    The protein has a moderate molecular weight and is convenient to use.

    07/12/2021

      NRP1 can be easily used and measured in experiment.

      04/20/2021

        NRP1 has a high purity.

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