NRP1
-
Official Full Name
neuropilin 1
-
Overview
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011] -
Synonyms
NRP1; neuropilin 1; NP1; NRP; BDCA4; CD304; VEGF165R; neuropilin-1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Mammalian Cell
- Mammalian cells
- C
- Fc
- hFc
- His
- Avi
- mFc
- Fc|His
- His (Fc)
- His|GST
- His|MBP
- human|IgG1|Fc
- Mouse|IgG2a|Fc
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- NRP1 Related Articles
NRP1 involved in several pathways and played different roles in them. We selected most pathways NRP1 participated on our site, such as Axon guidance, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Axon guidance | PPP3CB;EPHA6;ARPC5;EFNB3;EFNA3;FRS3;UNC5C;AP2A2;LAMTOR2 |
HTLV-I infection | CDC23;HLA-DRB4;MAPK8;PDGFRA;VDAC2;TRP53;DVL2;FZD5;APC |
NRP1 has several biochemical functions, for example, coreceptor activity, cytokine binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRP1 itself. We selected most functions NRP1 had, and list some proteins which have the same functions with NRP1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
coreceptor activity | CXCR4;RGMD;IGSF1;PVRL1;TMIGD2;ACKR3B;PVRL2;CCR5;ACVR2A |
cytokine binding | CD74;CNTFR;NOG;PARK7;ELANE;IL17F;Fzd4;CSF1R;CSF1RA |
growth factor binding | LIFR;FGFBP2;A2M;RHBDF1;HTRA1A;RHBDF2;RPL37;NRP2;GHR |
heparin binding | LIPC;SLIT2;CXCL11;ADAMTS1;RPL22;LXN;TENM1;COMP;ZFP207 |
metal ion binding | EXT1B;MAT2AA;EXTL2;KLK4;ZNF550;NUBP1;Scd1;ZNF584;ZBTB12.1 |
protein binding | MUSK;C12orf49;RNF6;JUND;OSTB;TRIM38;FAM133A;PYCRL;COG4 |
semaphorin receptor activity | PLXNA1;PLXNB2;PLXNA1B;NRP2;PLXNA3;NRP2A;NRP1;PLXNC1;PLXNB2A |
vascular endothelial growth factor binding | PDGFRA;PDGFRB;KDR;NRP1 |
vascular endothelial growth factor-activated receptor activity | FLT3;NRP2B;NRP2A;NRP2;NRP1;KDR;FLT4;PDGFRA;NRP1B |
NRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRP1.
VEGFA; KDR; FLNA; FLT1; RPL27; ptsN1; CSNK2A2
- Q&As
- Reviews
Q&As (6)
Ask a questionIt may be involved in the processes of angiography, inflammation, fibrosis and other processes in the lungs, and is related to the occurrence and development of lung diseases.
The high expression of NRP1 may be related to factors such as the aggressiveness of the tumor and the increased angiogenesis of the tumor.
Yes, NRP1, as a molecule with important biological functions and clinical significance, can be targeted as a target therapy.
This protein can be used as a potential marker in clinical diagnosis for tumor diagnosis and prognosis evaluation.
Yes, NRP1 may be related to the metabolism of drugs, the response to drug treatment, etc., which affects the efficacy and side effects of drugs.
NRP1 may be involved in the regulation of autoimmune responses, inflammatory responses, etc., and is related to the occurrence and development of immune diseases.
Customer Reviews (3)
Write a reviewThe protein has a moderate molecular weight and is convenient to use.
NRP1 can be easily used and measured in experiment.
NRP1 has a high purity.
Ask a Question for All NRP1 Products
Required fields are marked with *
My Review for All NRP1 Products
Required fields are marked with *