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NXF1

Official Full Name

nuclear RNA export factor 1
Overview

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.
Synonyms

NXF1; nuclear RNA export factor 1; DKFZp667O0311; Mex67; TAP; tip associating protein; mRNA export factor TAP; tip-associated protein; tip-associating protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NXF1-1427H	Recombinant Human NXF1, GST-tagged	E.coli	GST	42-346aa	$319 / 25ug
Human	NXF1-3622HCL	Recombinant Human NXF1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NXF1-1428H	Recombinant Human NXF1 protein, His-tagged	E.coli	His		Inquiry
Human	NXF1-2519H	Recombinant Human NXF1 Protein, His-tagged	E.coli	N-His	Ala2-His198	Inquiry
Mouse	NXF1-11014M	Recombinant Mouse NXF1 Protein	Mammalian Cell	His		Inquiry
Mouse	NXF1-6285M	Recombinant Mouse NXF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	NXF1-6285M-B	Recombinant Mouse NXF1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	NXF1-4135R	Recombinant Rat NXF1 Protein	Mammalian Cell	His		Inquiry
Rat	NXF1-3796R	Recombinant Rat NXF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Nxf1-406R	Recombinant Rat Nxf1 Protein, His-tagged	E.coli	His	Ala2~Tyr197	Inquiry
Rat	NXF1-3796R-B	Recombinant Rat NXF1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

NXF1 involved in several pathways and played different roles in them. We selected most pathways NXF1 participated on our site, such as Gene Expression, Herpes simplex infection, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with NXF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gene Expression	ZFP2;ANP32A;LSM10;SESN3;ADAR;AIMP2;NR4A2B;ZNF563;ZNF726
Herpes simplex infection	IL12A;NFKBIA;OAS1;CASP8;IFNA4;IL12B;EIF2AK4;MAVS;EEF1D
Influenza A	EIF2AK1;IFNA13;HSPA1A;NFKB1;XPO1;NXT1;Ccl12;NFKBIB;TNFRSF10B
Processing of Capped Intron-Containing Pre-mRNA	CSTF2;HNRNPL;METTL14;HNRPL;CD2BP2;WTAP;SNRNP35;HNRNPR;THOC4
RNA transport	EIF1;NUP210;THOC4;SUMO2;SMN2;EIF2B3;NUP133;RANBP2;NUP153
Ribosome biogenesis in eukaryotes	MPHOSPH10;PWP2;NXF3;ACK2;cka1;UTP15;TBL3;UTP6;UTP14C
Transport of Mature Transcript to Cytoplasm	SRSF11;U2AF2;SFRS3A;SLBP;NXF1
Transport of Mature mRNA Derived from an Intronless Transcript

NXF1 has several biochemical functions, for example, nucleotide binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NXF1 itself. We selected most functions NXF1 had, and list some proteins which have the same functions with NXF1. You can find most of the proteins on our site.

Function	Related Protein
nucleotide binding	DNM2B;RBFOX2;RBM12B;ARL3L2;RABL2;NXF1;TOR1L3;RAP1AA;SRSF9
poly(A) RNA binding	TTC6;BAG4;SRPK1;WBP11;DIMT1L;STRAP;HUWE1;ZFC3H1;ADD1
protein binding	OLR1;ABCD3;KLRC2;CUL5;MRPL44;NOS3;RAB11FIP3;RNF180;TSEN54
single-stranded RNA binding	POLR2G;STRBP;DLX2;SNRPC;IFIH1;ANXA1;LONP1;DHX58;TLR8

NXF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NXF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NXF1.

NUP62; NXT1; NUP153; SRSF1