OAT
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Official Full Name
ornithine aminotransferase
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Overview
This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. -
Synonyms
OAT; ornithine aminotransferase; ornithine aminotransferase, mitochondrial; gyrate atrophy; HOGA; ornithine aminotransferase precursor; GACR; OATASE; OKT; Ornithine aminotransferase (gyrate atrophy); Ornithine aminotransferase mitochondrial; Ornithine aminotransferase, mitochondrial precursor; Ornithine delta aminotransferase; Ornithine oxo acid aminotransferase; OTTHUMP00000020690; ornithine delta-aminotransferase; ornithine-delta-aminotransferase; ornithine-oxo-acid aminotransferase; ornithine--oxo-acid aminotransferase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- OAT Related Articles
OAT involved in several pathways and played different roles in them. We selected most pathways OAT participated on our site, such as Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with OAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arginine and proline metabolism | ALDH7A1;AMD1;GOT2A;Ckmm;CKBB;CARNS1;ALDH1B1;ALDH18A1;PRODH2 |
| Metabolic pathways | ACSM3;DAO.2;HOGA1;GCLM;glpK;GGT6;G6PC2;LIPC;B3GNT3 |
OAT has several biochemical functions, for example, identical protein binding, ornithine-oxo-acid transaminase activity, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OAT itself. We selected most functions OAT had, and list some proteins which have the same functions with OAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | NOL3;TRIM39;TMEM115;DVL2;TARDBP;LYZ;SOD2;UBE4A;HSP90AA1 |
| ornithine-oxo-acid transaminase activity | |
| pyridoxal phosphate binding | GPT2L;CBSA;MOSC2;ACCSL;SHMT2;SDS;AGXT;ACCS;ALAS1 |
OAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OAT here. Most of them are supplied by our site. Hope this information will be useful for your research of OAT.
bb1_human; SSSCA1; EIF1B; PTP4A3; MCC; HLA-B; EIF6; ARF6; CCNA1; OTUD4; DMWD; PRKAB1; TRAF6; NUDT3; SLC35F6; UBQLN4; MYC; ATF2; ICT1; MAP1LC3A
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