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OAZ1

  • Official Full Name

    ornithine decarboxylase antizyme 1

  • Overview

    Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation.
  • Synonyms

    OAZ1; ornithine decarboxylase antizyme 1; OAZ; antizyme 1; AZI; MGC138338; ODC-Az;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human OAZ1-543H Recombinant Human OAZ1 Mammalian Cell His
Human OAZ1-450HCL Recombinant Human OAZ1 lysate HEK293 N/A
Human OAZ1-4759H Recombinant Human OAZ1 Protein (Phe95-Glu219), N-GST tagged E.coli N-GST Phe95-Glu219
Human OAZ1-2522H Recombinant Human OAZ1 Protein, His-tagged E.coli N-His Phe95-Glu219
Human OAZ1-3711H Recombinant Human OAZ1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human OAZ1-3711H-B Recombinant Human OAZ1 Protein Pre-coupled Magnetic Beads HEK293
Mouse OAZ1-11047M Recombinant Mouse OAZ1 Protein Mammalian Cell His
Mouse OAZ1-6300M-B Recombinant Mouse OAZ1 Protein Pre-coupled Magnetic Beads HEK293
Mouse OAZ1-6300M Recombinant Mouse OAZ1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat OAZ1-4149R Recombinant Rat OAZ1 Protein Mammalian Cell His
Rat OAZ1-3811R Recombinant Rat OAZ1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat OAZ1-3811R-B Recombinant Rat OAZ1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey OAZ1-760C Recombinant Cynomolgus OAZ1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey OAZ1-504C-B Recombinant Cynomolgus Monkey OAZ1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey OAZ1-504C Recombinant Cynomolgus Monkey OAZ1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken OAZ1-6478C Recombinant Chicken OAZ1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • OAZ1 Related Articles

OAZ1 involved in several pathways and played different roles in them. We selected most pathways OAZ1 participated on our site, such as Aurora A signaling, Metabolism, Metabolism of amino acids and derivatives, which may be useful for your reference. Also, other proteins which involved in the same pathway with OAZ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aurora A signalingTACC3;TPX2;TACC1;AURKAIP1;OAZ1;NDEL1;GADD45A;CENPA;AURKB
MetabolismSLC4A1A;FAM213B;EPM2A;MED19;PDK3;CYP2W1;NDUFAF2;COX6B1;PAICS
Metabolism of amino acids and derivativesSLC25A10;NQO1;CDO1;SLC6A12;PPM1K;AZIN2;DBH;AZIN1A;SLC25A15B
Metabolism of polyaminesCKM;CKB;AZIN2;PAOX;OAZ2;AZIN1;SLC6A8;SLC25A15A;CKMB
Nucleotide MetabolismOAZ1;MTHFD2;ADSL;ADSS
Regulation of ornithine decarboxylase (ODC)OAZ2;AZIN1A;OAZ3;AZIN1;AZIN1B;OAZ1;OAZ1A;OAZ2B

OAZ1 has several biochemical functions, for example, ornithine decarboxylase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OAZ1 itself. We selected most functions OAZ1 had, and list some proteins which have the same functions with OAZ1. You can find most of the proteins on our site.

Function Related Protein
ornithine decarboxylase inhibitor activityOAZ1A;OAZ1;OAZ2B;OAZ2;OAZ2A;OAZ3
protein bindingPAAF1;HYPM;CCDC67;CCNF;ZNF346;ZZZ3;CRCP;PSMA2;TLR2

OAZ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OAZ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OAZ1.

EGFR; ATXN1; PIAS4; AZIN1; ODC1; RAB7A; PLXNA3; GBE1; CAMSAP2; TAF1B; GPATCH4; RNF20; PGM2L1; UPF1; LENG8; SRA1; CEPT1

Murakami, Y; Suzuki, J; et al. Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland. AMINO ACIDS 38:591-601(2010).
Svensson, KJ; Welch, JE; et al. Hypoxia-Mediated Induction of the Polyamine System Provides Opportunities for Tumor Growth Inhibition by Combined Targeting of Vascular Endothelial Growth Factor and Ornithine Decarboxylase. CANCER RESEARCH 68:9291-9301(2008).
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