OCRL
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Official Full Name
oculocerebrorenal syndrome of Lowe
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Overview
This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. -
Synonyms
OCRL; oculocerebrorenal syndrome of Lowe; inositol polyphosphate 5-phosphatase OCRL-1; OCRL1; Lowe oculocerebrorenal syndrome protein; phosphatidylinositol polyphosphate 5-phosphatase; LOCR; NPHL2; INPP5F; OCRL-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
OCRL involved in several pathways and played different roles in them. We selected most pathways OCRL participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with OCRL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | INPP5KA;PLCG1;MINPP1A;MTMR6;MTMR2;PLCD1B;MTMR7A;MTM1;NUDT4 |
| Metabolic pathways | ALDH1A3;GPAA1;COQ7;IVD;PFKMA;SPTLC3;OGDH;CES1D;OXSM |
| Phosphatidylinositol signaling system | CALM3B;PIK3R2;PIK3CA;PIP5K1C;PIK3C3;IP6K3;IPMK;PLCD1A;PIK3R1 |
OCRL has several biochemical functions, for example, GTPase activator activity, Rac GTPase binding, inositol phosphate phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OCRL itself. We selected most functions OCRL had, and list some proteins which have the same functions with OCRL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | NCKAP1L;RINL;TBC1D9;ARHGAP1;GDI1;AGFG1;ARHGAP35;ACAP3;RASA4 |
| Rac GTPase binding | NCF2;CDKL5;SRGAP3;DVL1;PAK2;SRGAP2A;DOCK4;PAK6;RALBP1 |
| inositol phosphate phosphatase activity | SGPP2;NT5DC3;SACM1LB;OCRL;PXYLP1;TENC1;CTDSPL2A;SACM1LA;CTDSPL2B |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | INPP5E;PTPMT1;EPM2A;OCRL;SYNJ2;INPP5B |
| protein binding | ERP44;ERC2;FOXP4;DIXDC1;ASCL4;PEX6;ATP6V1D;MRPS31;BCL2A1A |
OCRL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OCRL here. Most of them are supplied by our site. Hope this information will be useful for your research of OCRL.
RAB8A; RAB5A
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