ODC1
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Official Full Name
ornithine decarboxylase 1
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Overview
Ornithine Decarboxylase (ODC) is the first and rate limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. ODC activity is induced by numerous agents known to promote cell proliferation including growth factors, mit -
Synonyms
ODC1; ornithine decarboxylase 1; ornithine decarboxylase; ODC;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- T7
- C
- Involved Pathway
- Protein Function
- Interacting Protein
ODC1 involved in several pathways and played different roles in them. We selected most pathways ODC1 participated on our site, such as Arginine and proline metabolism, Glutathione metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ODC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arginine and proline metabolism | SMOX;CKB;ALDH3A2A;ALDH2.2;DAO.3;PYCR1B;SRM;SMS;Ckmm |
| Glutathione metabolism | GSTT2B;GSTA2;MGST1.2;GGCTA;GPX1A;GGT1A;GSTM;GSTA4;SMS |
| Metabolic pathways | ALAS1;MAPK1IP1L;COX10;ALDH1A2;ACACB;UCK2B;PLCD1;PPAT;GMPPAA |
ODC1 has several biochemical functions, for example, ornithine decarboxylase activity, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ODC1 itself. We selected most functions ODC1 had, and list some proteins which have the same functions with ODC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ornithine decarboxylase activity | |
| protein binding | TRIM5;BRD2;NEK6;DYNC1LI1;SLC4A1A;CBR4;TCP1;DNM3;PITPNC1 |
| protein homodimerization activity | SNX2;NR2F2;TMEM173;DMRTB1;ALX1;CBX1;ATPIF1B;CUBN;HLA-G |
ODC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ODC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ODC1.
KAT5; GORASP2; OAZ3; OAZ2; TK1; TMOD1; SSR1; STX17; CSNK2B; MAP2K1; BAAT; TSTD2
- Q&As
- Reviews
Q&As (7)
Ask a questionAltered ODC1 activity is linked to cancer progression, as polyamines are vital for rapid cell division.
Targeting ODC1 offers potential for cancer therapy by controlling polyamine levels in rapidly dividing cells.
ODC1 is involved in tissue repair processes, aiding in cell regeneration and healing.
ODC1 works with other metabolic enzymes, coordinating the synthesis and regulation of polyamines.
ODC1, ornithine decarboxylase, is crucial for initiating polyamine synthesis, essential for cellular growth and function.
It plays a key role in cell proliferation by providing polyamines necessary for DNA and protein synthesis.
Genetic variations in ODC1 can lead to differences in polyamine synthesis, affecting cell growth and metabolism.
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