OLIG2
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Official Full Name
oligodendrocyte lineage transcription factor 2
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Overview
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. -
Synonyms
OLIG2; oligodendrocyte lineage transcription factor 2; oligodendrocyte transcription factor 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- OLIG2 Related Articles
- OLIG2 Related Research Area
OLIG2 involved in several pathways and played different roles in them. We selected most pathways OLIG2 participated on our site, such as Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with OLIG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Neural Crest Differentiation | ZIC1;DMBX1;CTBP2;SOX10;TFAP2B;SOX5;TCF4;LHX2;CDH7 |
OLIG2 has several biochemical functions, for example, DNA binding, HMG box domain binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OLIG2 itself. We selected most functions OLIG2 had, and list some proteins which have the same functions with OLIG2. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZFPM2;ZFP692;DMC1;ZNF493;RCOR1;ZFP553;HER1;KIF4A;ZNF672 |
HMG box domain binding | UTF1;HOXC4;ALX4;SP1;JUN;PAX3;MEOX1;HHEX;POU3F3 |
protein homodimerization activity | ODZ4;GRM6;GSTM2;HSP90AA1;TOX3;GABPB2;HLCS;CADM1;BCL2L10 |
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | HNF1B;SPI1;SRY;GATA4;NKX2-1;OLIG2;CREB1;PAX3;THRA |
OLIG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OLIG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of OLIG2.
- Q&As
- Reviews
Q&As (7)
Ask a questionOLIG2 is essential for the development and maturation of oligodendrocytes, which form myelin in the nervous system.
OLIG2 is implicated in the development of gliomas, influencing tumor cell differentiation and growth.
OLIG2 plays a crucial role in directing neural stem cells to differentiate into oligodendrocytes and neurons in the CNS.
OLIG2 affects interactions between neurons and glial cells, essential for proper brain development.
Changes in OLIG2 can lead to neurodevelopmental disorders due to altered brain cell development and function.
OLIG2 contributes to myelin repair and regeneration, crucial in demyelinating diseases like multiple sclerosis.
OLIG2 modulates gene expression, guiding key neurodevelopmental processes and cell fate decisions.
Customer Reviews (3)
Write a reviewSwift protein sequencing, invaluable for protein identification.
Consistent western blot results, a lab necessity for us.
Great protein crystallization service, vital for structural biology studies.
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