opn4
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  • Official Full Name
  • opsin 4
  • Background
  • visual pigment of phototransducing retinal ganglion cells involved in setting the circadian clock
  • Synonyms
  • OPN4; opsin 4; opsin 4 (melanopsin); melanopsin; MOP; opsin-4; MGC142118
Cat.#:OPN4-806HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human OPN4
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Cat.#:OPN4-4192RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat OPN4 Protein
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Cat.#:OPN4-3445CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken OPN4
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Cat.#:OPN4-3574HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human OPN4 293 Cell Lysate
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Involved Pathway

OPN4 involved in several pathways and played different roles in them. We selected most pathways OPN4 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with OPN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)
LTB4R; AMCF-II; FFAR3; KISS1; RXFP2; CHRM4; LPAR2A; ADRA2A; LPAR1; GAL
G alpha (q) signalling events
NMBB; DGKB; CHRM3; PROKR1A; PROK2; RGS19; NMS; EDN1; ABHD12; DGKQ
GPCR downstream signaling
OR52J3; OPN1SW1; RGS4; PTHLH; PIK3R6; ANXA1C; RGS21; OR52B4; QRFP; CALCB
GPCR ligand binding
EDN3; TAC1; PENKB; OPN1MW; NMBA; GPR77; EDN2; CCRL2; ADM2; GPR31
GPCRs, Class A Rhodopsin-like
OR10A5; APLNR; OPN1SW; GPR27; OPN1LW; GPR18; SSTR3; DRD3; GPR85; RRH
Gastrin-CREB signalling pathway via PKC and MAPK
ANXA1C; OPN4; CCK; CASR; PROKR1; OXTRL; ABHD6B; NTS; NPSR1; NPFF
Opsins
OPN1LW1; OPN4A; RGS1; OPN4; OPN1LW2; OPN5; OPN4.1; OPN4B; RGR; OPN1SW1
Signal Transduction
PRC1B; MDKB; PRKCHB; ARHGEF1B; OR52J3; HHAT; ARHGAP17B; RYK; GNA13B; RAMP3

Protein Function

OPN4 has several biochemical functions, for example, 11-cis retinal binding, G-protein coupled photoreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OPN4 itself. We selected most functions OPN4 had, and list some proteins which have the same functions with OPN4. You can find most of the proteins on our site.
Function
Related Protein
Function 11-cis retinal binding
Related Protein RLBP1; OPN5; OPN4
Function G-protein coupled photoreceptor activity
Related Protein GNAT2; EXORH; OPN4A; GNAT3; OPN4

OPN4 Related Articles

Kang, SW; Leclerc, B; et al. MELANOPSIN EXPRESSION IN DOPAMINE-MELATONIN NEURONS OF THE PREMAMMILLARY NUCLEUS OF THE HYPOTHALAMUS AND SEASONAL REPRODUCTION IN BIRDS. NEUROSCIENCE 170:200-213(2010).
Pires, SS; Hughes, S; et al. Differential Expression of Two Distinct Functional Isoforms of Melanopsin (Opn4) in the Mammalian Retina. JOURNAL OF NEUROSCIENCE 29:12332-12342(2009).
Kubo, Y; Akiyama, M; et al. Molecular cloning, mRNA expression, and immunocytochemical localization of a putative blue-light photoreceptor CRY4 in the chicken pineal glandnn. JOURNAL OF NEUROCHEMISTRY 97:1155-1165(2006).