orai1
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  • Official Full Name
  • ORAI calcium release-activated calcium modulator 1
  • Background
  • The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).
  • Synonyms
  • ORAI1; ORAI calcium release-activated calcium modulator 1; TMEM142A, transmembrane protein 142A; calcium release-activated calcium channel protein 1; calcium release activated calcium modulator 1; CRACM1; FLJ14466; protein orai-1; transmembrane protein 1
Cat.#:ORAI1-981HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ORAI1
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Cat.#:ORAI1-4198RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ORAI1 Protein
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Cat.#:ORAI1-2364CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ORAI1
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Involved Pathway

ORAI1 involved in several pathways and played different roles in them. We selected most pathways ORAI1 participated on our site, such as Calcium signaling pathway, cAMP signaling pathway, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ORAI1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
ATP2B1; TNNC1A; GNAL; P2RX2; PRKACG; CALM2; VDAC2; HTR2CL1; ADCY1A; CCKBR
cAMP signaling pathway
PRKACA; CREB3L3; BDNF; CALM4; MAPK3; VAV2; HCN4; CALM2; FXYD1; PDE3B
Platelet activation
GUCY1B3; PRKG1; P2RX1; PTGIR; GP1BA; FYN; PPP1CA; MAPK1; GNAS; TLN1
Renin secretion
PDE3A; AQP1; PPP3CA; PRKACG; CALML3; LOC100328615; CLCA2; ITPR3; AGTR1B; CALM3
Aldosterone synthesis and secretion
PLCB4; GNAS; CAMK1G; ITPR1; CAMK1D; PRKD1; CALM2; ADCY6; PLCB2; CREB3L3
Primary i
ZAP70; UNG; DCLRE1C; RFXAP; PTPRC; RAG2; CD79A; IL7R; IKBKG; Cd79a, Cd79b
nodeficiency
CD40; ZAP70; CD8A; TAP1; CD3E; TNFRSF13B; RFXAP; RFX5; AIRE; PTPRC

Protein Function

ORAI1 has several biochemical functions, for example, calmodulin binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ORAI1 itself. We selected most functions ORAI1 had, and list some proteins which have the same functions with ORAI1. You can find most of the proteins on our site.
Function
Related Protein
Function calmodulin binding
Related Protein CAMK1D; KCNH1; MYO9B; CAMKVB; MYO1D; EPB41B; MYH7; ADD2; KCNN1; MARCKS
Function identical protein binding
Related Protein BTK; CD74; SNX8; RAF1; ACPP; ADIPOR1; ACADM; ERN1; CLDN8; NME1
Function protein binding
Related Protein APOA4; LRRIQ3; NDRG4; TBPL1; TERF1; WT1; PARVA; HAUS1; NDP; MYL12B
Function store-operated calcium channel activity
Related Protein TRPC5A; TRPC4; TRPC7A; ORAI3; ORAI1B; TRPC5; ZP3; STIM2; ORAI2; TRPC1

Interacting Protein

ORAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ORAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ORAI1.
STIM1; ATP2C2

ORAI1 Related Articles

Gaida, K; Salimi-Moosavi, H; et al. Inhibition of CRAC with a human anti-ORAI1 monoclonal antibody inhibits T-cell-derived cytokine production but fails to inhibit a T-cell-dependent antibody response in the cynomolgus monkey. JOURNAL OF IMMUNOTOXICOLOGY 12:164-173(2015).
Guzman, R; Valente, EG; et al. Expression of ORAI1, a Plasma Membrane Resident Subunit of the CRAC Channel, in Rodent and Non-rodent Species. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 62:864-878(2014).