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OSBP

Official Full Name

oxysterol binding protein
Overview

Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the;nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase.
Synonyms

OSBP; oxysterol binding protein; oxysterol-binding protein 1; OSBP1; OSBP 1; OSBP1_HUMAN; Oxysterol binding protein 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
His|T7
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	OSBP-8006H	Recombinant Human OSBP protein, His & T7-tagged	E.coli	His/T7	Thr546~Phe807 (Accession # P22059)	Inquiry
Human	OSBP-3544HCL	Recombinant Human OSBP 293 Cell Lysate	HEK293	N/A		Inquiry
Human	OSBP-1587H	Recombinant Human OSBP Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	OSBP-774HFL	Recombinant Full Length Human OSBP Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	OSBP-1587H-B	Recombinant Human OSBP Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Osbp-4606M	Recombinant Mouse Osbp Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	OSBP-3250R	Recombinant Rhesus monkey OSBP Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	OSBP-3068R	Recombinant Rhesus Macaque OSBP Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	OSBP-3068R-B	Recombinant Rhesus Macaque OSBP Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	OSBP-7336Z	Recombinant Zebrafish OSBP	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
OSBP Related Articles

OSBP involved in several pathways and played different roles in them. We selected most pathways OSBP participated on our site, such as Metabolism, Metabolism of lipids and lipoproteins, Sphingolipid de novo biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolism	DDAH2;ACOT11A;COX10;ZDHHC21;ARV1;CYP2A13;CIAPIN1;DPYDA.1;GCKR
Metabolism of lipids and lipoproteins	CLPS;ECI1;CYP4F22;CERS3B;AKR1C2;CYP2AD6;PPM1LA;COQ6;ACOT12
Sphingolipid de novo biosynthesis	SGMS2;ACER1;CERS4A;COL4A3BP;OSBP;GDF1;SPTLC1;FA2H;VAPB
Sphingolipid metabolism	ARSH;ARSK;GBA2;SUMF2;GDF1;SERINC1;ASAH1A;UGT8;GALCB

OSBP has several biochemical functions, for example, oxysterol binding, phosphatidylinositol-4-phosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OSBP itself. We selected most functions OSBP had, and list some proteins which have the same functions with OSBP. You can find most of the proteins on our site.

Function	Related Protein
oxysterol binding	GPR183;OSBPL5;RORA;OSBP;RORC
phosphatidylinositol-4-phosphate binding	OSBPL5;PLEKHA8;SH3PXD2B;D6WSU116E;LANCL2;SNX3;PLEKHF1;OSBPL8;RS1
protein binding	RPL22;KAT2A;KATNA1;Mill2;ULK3;SLC48A1;FBXL8;ZFAND6;NDUFB9
protein domain specific binding	EZR;YWHAE;GABRR3;CALM2;TACC3;TJP1;SKIL;GSN;SERPINB1A
sterol transporter activity	NPC1;SCP2A;OSBP;C20orf79;SCP2

OSBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSBP here. Most of them are supplied by our site. Hope this information will be useful for your research of OSBP.

sseL; sseL; FKBP6; CSNK2A1; SP1; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; VAPA

Udagawa, O; Ito, C; et al. Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family. GENES TO CELLS 19:13-27(2014).

Nhek, S; Ngo, M; et al. Regulation of Oxysterol-binding Protein Golgi Localization through Protein Kinase D-mediated Phosphorylation. MOLECULAR BIOLOGY OF THE CELL 21:2327-2337(2010).