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OTUB2

Official Full Name

OTU domain, ubiquitin aldehyde binding 2
Overview

This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain.
Synonyms

OTUB2; OTU domain, ubiquitin aldehyde binding 2; C14orf137, chromosome 14 open reading frame 137; ubiquitin thioesterase OTUB2; FLJ21916; MGC3102; C14orf137; Deubiquitinating enzyme OTUB2; OTB2; OTU domain containing ubiquitin aldehyde binding protein 2; OTU domain-containing ubiquitin aldehyde-binding protein 2; OTU2; OTUB2_HUMAN; Otubain 2; Otubain-2; Ubiquitin specific processing protease OTUB2; Ubiquitin specific protease otubain 2; Ubiquitin-specific-processing protease OTUB2; ubiquitin-specific protease otubain 2;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	OTUB2-30525TH	Recombinant Human OTUB2, His-tagged	E.coli	His	234 amino acids	Inquiry
Human	OTUB2-174H	Recombinant Human OTUB2, His-tagged	E.coli	His		Inquiry
Human	OTUB2-64H	Recombinant Human OTUB2, His-tagged	E.coli	His		Inquiry
Human	OTUB2-2534H	Recombinant Human OTUB2 protein, His-tagged	E.coli	His	Met1-His234	Inquiry
Human	OTUB2-3515HCL	Recombinant Human OTUB2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	OTUB2-353H	Recombinant Human OTUB2 Protein	E.coli	N/A		Inquiry
Human	OTUB2-4847H	Recombinant Human OTUB2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	OTUB2-13HFL	Active Recombinant Full Length Human OTUB2 Protein, N-His tagged	E.coli	N-His	Full Length	Inquiry
Human	OTUB2-5173H	Recombinant Human OTUB2 Protein (Met1-His234), N-Gst tagged	E.coli	N-Gst	Met1-His234	Inquiry
Human	OTUB2-354H	Recombinant Human OTUB2 Protein, GST-tagged	E.coli	GST		Inquiry
Mouse	Otub2-4625M	Recombinant Mouse Otub2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
OTUB2 Related Research Area

OTUB2 involved in several pathways and played different roles in them. We selected most pathways OTUB2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with OTUB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

OTUB2 has several biochemical functions, for example, NEDD8-specific protease activity, protein binding, ubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OTUB2 itself. We selected most functions OTUB2 had, and list some proteins which have the same functions with OTUB2. You can find most of the proteins on our site.

Function	Related Protein
NEDD8-specific protease activity	OTUB1B;OTUB2;OTUB1A;OTUB1
protein binding	ATG3;EIF3J;SVIP;TNFAIP3;CD22;RPL13;SORBS2;PLEKHG6;MYPOP
ubiquitin binding	USP16;VPS28;USP25;CRY2;MARK4;AUP1;UBE2N;UBAP1;UCHL1
ubiquitin-specific protease activity	CYLD;USP22;USP13;USP49;USP12;OTUD4;OTUD5A;USP1;USP10

OTUB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OTUB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of OTUB2.

MID1; REL; TP53BP2; CPSF6; SIAH1; FAM168A; ARRDC3

Deubiquitinating Enzymes (DUBs)