Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

AMY2A

  • Official Full Name

    amylase, alpha 2A (pancreatic)

  • Overview

    Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.
  • Synonyms

    AMY2A; amylase, alpha 2A (pancreatic); AMY2, amylase, alpha 2A; pancreatic; pancreatic alpha-amylase; 1,4 alpha D glucan glucanohydrolase; Alpha amylase; AMY2; AMY2B; Amylase, alpha 2A; Amylase, pancreatic, A; Glycogenase; PA; alpha-amylase; OTTHUMP00000012694; found in the pancreas; pancreatic amylase 2A; pancreatic amylase alpha 2A; amylase, pancreatic, alpha-2A; 1,4-alpha-D-glucan glucanohydrolase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Transfected Stable Cell Lines
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Rhesus
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Pancreas
  • Wheat Germ
  • Fc
  • GST
  • hFc
  • His
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AMY2A-6978H Recombinant Human AMY2A protein, His & T7-tagged E.coli His/T7 Asp188~Val432 (Accession # P04746)
Human AMY2A-535H Recombinant Human AMY2A protein, GST-tagged Wheat Germ GST
Human AMY2A-8569H Recombinant Human AMY2A, His tagged Human Cell His
Human AMY2A-1351HCL Recombinant Human AMY2A cell lysate Human Cell N/A
Human AMY2A-3520H Recombinant Human AMY2A protein, His-tagged E.coli His 162-511 aa
Human AMY2A-8353H Native Human AMY2A Pancreas N/A
Human AMY2A-16H Human alpha-amylase Reference Standard N/A
Human AMY2A-1031HF Recombinant Full Length Human AMY2A Protein, GST-tagged In Vitro Cell Free System GST 511 amino acids
Human AMY2A-0555H Recombinant Human AMY2A Protein (Asp188-Val432), N-His-tagged E.coli N-His Asp188-Val432
Cynomolgus Monkey AMY2A-194C Recombinant Cynomolgus AMY2A, Fc-tagged Human Cell Fc Met1-Leu511
Cynomolgus Monkey AMY2A-56C Recombinant Cynomolgus AMY2A, His tagged Human Cell Fc
Cynomolgus Monkey AMY2A-001CCL Recombinant Cynomolgus AMY2A cell lysate Human Cell N/A
Rhesus AMY2A-538R Recombinant Rhesus AMY2A protein, His-tagged HEK293 His Met1-Leu511
Rhesus AMY2A-697R Recombinant Rhesus AMY2A protein, hFc-tagged HEK293 hFc Met1-Leu511
Zebrafish AMY2A-12252Z Recombinant Zebrafish AMY2A Mammalian Cell His
Chicken AMY2A-1116C Recombinant Chicken AMY2A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AMY2A Related Articles

AMY2A involved in several pathways and played different roles in them. We selected most pathways AMY2A participated on our site, such as Starch and sucrose metabolism, Metabolic pathways, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMY2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Starch and sucrose metabolismPYGMA;GPIB;PGM1;HK1;PGM2L1;AMY2A;UGT2A3;HK3;UGT5G1
Metabolic pathwaysPIGC;ALDOAA;CHIA.4;PYCR1B;ODC1;B3GNT5;NMNAT1;ACADS;PGK2
Pancreatic secretionPLA2G5;Car2;KCNQ1;ATP1B4;ATP2B1;PLA2G2D;LOC780933;PRKCA;CELA2B
Carbohydrate digestion and absorptionATP1B3;PLCB2;PRKCB;ATP1B2;AKT1;HK2;SLC2A5;AMY2A4;SLC5A1

AMY2A has several biochemical functions, for example, alpha-amylase activity, calcium ion binding, chloride ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AMY2A itself. We selected most functions AMY2A had, and list some proteins which have the same functions with AMY2A. You can find most of the proteins on our site.

Function Related Protein
alpha-amylase activityAMY1A;AMY2A5;AMY2A;AMY2A2;AMY2B;AMY1B;AMY2A4;Amy1;AMY2A3
calcium ion bindingPCDH2G4;MFGE8B;S100G;SCUBE1;PCDHGA5;SYT11;AGRN;NCALDB;DGKG
chloride ion bindingSLC22A6;ACE;CTSC;AMY2A;NLGN4X;Amy1

AMY2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMY2A here. Most of them are supplied by our site. Hope this information will be useful for your research of AMY2A.

TRIAP1; IGF1R; CDK6

TSUNODA, Y; OWYANG, C; et al. THE REGULATORY SITE OF FUNCTIONAL GTP-BINDING PROTEIN-COUPLED TO THE HIGH-AFFINITY CHOLECYSTOKININ RECEPTOR AND PHOSPHOLIPASE A(2) PATHWAY IS ON THE G(BETA) SUBUNIT OF G(Q) PROTEIN IN PANCREATIC ACINI. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 211:648-655(1995).
  • Q&As
  • Reviews

Q&As (13)

Ask a question
How is the AMY2A protein regulated in the body? 06/23/2022

The regulation of the AMY2A protein is primarily mediated by hormonal signals and the presence of carbohydrates in the digestive system. When carbohydrates are consumed, the pancreas releases the hormone called pancreatic amylase. This hormone stimulates the production and release of alpha-amylase, including the AMY2A protein, from the pancreas into the small intestine to aid in carbohydrate digestion.

Are there any populations or ethnic groups that have a higher or lower AMY2A gene copy number compared to others? 03/01/2022

Research suggests that there is some variation in AMY2A gene copy number among different populations and ethnic groups.

Can variations in the AMY2A gene impact carbohydrate metabolism? 06/19/2021

Yes, variations in the AMY2A gene, such as copy number variations, have been associated with differences in carbohydrate metabolism. Individuals with a higher number of AMY2A gene copies tend to have higher levels of alpha-amylase enzyme production, which may result in more efficient carbohydrate digestion and absorption.

Are there any health conditions associated with mutations in the AMY2A gene? 09/28/2020

While mutations specifically in the AMY2A gene are not commonly associated with specific health conditions, variations in the copy number of the AMY2A gene have been linked to certain metabolic and digestive disorders. For example, individuals with a lower number of AMY2A gene copies may have reduced amylase production, leading to impaired carbohydrate digestion and potential susceptibility to conditions like insulin resistance and obesity.

Is the AMY2A protein involved in any processes outside of carbohydrate digestion? 03/09/2020

The primary role of the AMY2A protein is in carbohydrate digestion. However, there is emerging evidence suggesting potential roles for alpha-amylase in processes beyond digestion. For example, some studies have suggested that amylase may play a role in adipogenesis (the formation of fat cells) and lipid metabolism. However, further research is needed to fully understand these potential roles and their implications.

Are there any dietary factors that can affect the expression or activity of the AMY2A protein? 06/07/2019

It is believed that dietary factors can influence the expression and activity of the AMY2A protein. For example, diets high in carbohydrates may stimulate the production and release of alpha-amylase, including the AMY2A protein, to aid in carbohydrate digestion.

Can the AMY2A gene copy number be tested through genetic testing? 11/20/2018

Yes, it is possible to determine the AMY2A gene copy number through genetic testing. Various methods, such as quantitative polymerase chain reaction (qPCR) or droplet digital PCR (ddPCR), can be used to assess the copy number of the AMY2A gene.

Can the AMY2A protein be used as a diagnostic or therapeutic target for any conditions? 05/31/2018

The AMY2A protein is currently not used as a diagnostic or therapeutic target for specific conditions. However, understanding variations in the AMY2A gene and their impact on carbohydrate metabolism may have implications for personalized nutrition and diet recommendations. Additionally, further research may uncover potential therapeutic interventions targeting the AMY2A protein or related pathways for certain metabolic disorders.

How does the AMY2A gene copy number affect carbohydrate digestion? 03/26/2018

The AMY2A gene encodes the alpha-amylase enzyme, which is responsible for breaking down complex carbohydrates (starches) into smaller sugar molecules. The number of AMY2A gene copies a person has can influence the overall production of alpha-amylase protein and, consequently, their ability to digest carbohydrates. Individuals with a higher AMY2A gene copy number typically have higher alpha-amylase production, leading to more efficient carbohydrate digestion.

Is the AMY2A protein linked to any diseases? 09/04/2017

The AMY2A protein itself is not directly linked to diseases. However, dysregulation of carbohydrate metabolism due to variations in AMY2A gene copy number or other genetic factors can contribute to the development of certain conditions. For instance, alterations in carbohydrate metabolism can impact blood sugar control and insulin sensitivity, which are key factors in the development of type 2 diabetes.

Are there any genetic variations or mutations associated with the AMY2A gene? 05/15/2017

Yes, there are genetic variations and mutations associated with the AMY2A gene. One well-known variation is the copy number variation (CNV) of the AMY2A gene, which refers to the number of gene copies an individual has. Humans can have different numbers of AMY2A gene copies, with some individuals having more copies than others. This variation may affect the amount of alpha-amylase enzyme produced and potentially influence carbohydrate digestion and metabolism.

How does the AMY2A protein function in carbohydrate digestion? 01/18/2017

The AMY2A protein functions by cleaving the glycosidic bonds between sugar units in complex carbohydrates. It hydrolyzes starch, which is a polysaccharide made up of glucose units, into smaller sugar molecules like maltose. These smaller sugars are more easily absorbed in the small intestine and can be further metabolized by the body for energy.

Can variations in AMY2A gene copy number be inherited? 10/23/2016

Yes, variations in AMY2A gene copy number can be inherited. The number of copies of the AMY2A gene a person has is determined by their genetic makeup, which is a combination of genetic material inherited from both parents. Therefore, if a parent has a certain number of AMY2A gene copies, their child has a chance of inheriting a similar number of gene copies.

Customer Reviews (4)

Write a review
Reviews
08/18/2022

    Manufacturers should ensure the consistency and quality of AMY2A protein products.

    09/01/2020

      They can offer detailed characterization data, including purity, stability, and functional assessments, to support researchers' confidence in using the protein in their trials.

      06/10/2020

        Manufacturers can support researchers in developing assays to measure AMY2A protein levels or activity specific to their clinical trial settings.

        06/19/2019

          This may involve guidance in selecting appropriate detection methods, providing assay components, or optimizing protocols for optimal performance and sensitivity.

          Ask a Question for All AMY2A Products

          Required fields are marked with *

          My Review for All AMY2A Products

          Required fields are marked with *

          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends