PADI4
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Official Full Name
peptidyl arginine deiminase, type IV
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Overview
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. -
Synonyms
PADI4; peptidyl arginine deiminase, type IV; PADI5, peptidyl arginine deiminase, type V; protein-arginine deiminase type-4; PAD; PDI4; PDI5; EC 3.5.3.15; HL 60 PAD; PAD 4; PADI 4; PADI 5; PADI H protein; PADI5; PDI 4; PDI 5; Peptidyl arginine deiminase type IV; Peptidyl arginine deiminase type V; Peptidylarginine deiminase IV; Protein arginine deiminase; Protein arginine deiminase type 4; Protein arginine deiminase type IV; HL-60 PAD; PADI-H protein; OTTHUMP00000002482; protein-arginine deiminase type IV; peptidyl arginine deiminase, type V; PAD4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Baculovirus-Insect cells
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect cell
- Insect Cell
- Insect cells
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- His|GST
- DDK
- Myc|DDK
- N/A
- N
- No tag
- Strep
- TwinStrep
- Involved Pathway
- Protein Function
- Interacting Protein
- PADI4 Related Articles
- PADI4 Related Research Area
PADI4 involved in several pathways and played different roles in them. We selected most pathways PADI4 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, protein citrullination, which may be useful for your reference. Also, other proteins which involved in the same pathway with PADI4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | KDM2AA;KDM5B;TADA1;PADI2;ARID4A;KIAA1267;KDM1B;KAT7A;NCOA2 |
| Chromatin organization | CHD4A;RBBP7;KDM2AA;RUVBL2;CARM1;TADA1;GATAD2B;BRD8;KDM5C |
| protein citrullination | PADI6;PADI2;PADI3;PADI4;PADI1 |
PADI4 has several biochemical functions, for example, arginine deiminase activity, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PADI4 itself. We selected most functions PADI4 had, and list some proteins which have the same functions with PADI4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arginine deiminase activity | |
| calcium ion binding | PPEF2;PKD1L2;SYT5A;PVALB2;MAN1C1;CCBE1;CAPN12;MMP15;NOL3 |
| protein binding | CIB2;TBL1X;RANBP3;TMEM86B;ZNF703;ICAM3;WBP4;ADAM17;IL1R1 |
| protein-arginine deiminase activity | PADI6;PADI4;PADI3;PADI1;PADI2 |
PADI4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PADI4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PADI4.
ANXA4; LRRK2; DNPEP
- Q&As
- Reviews
Q&As (7)
Ask a questionPADI4 is predominantly expressed in various tissues, including synovial tissues, immune cells, and certain epithelial cells.
PADI4 plays a crucial role in citrullination, a process that converts arginine residues to citrulline, influencing protein structure and function.
Peptidyl arginine deiminase 4 (PADI4) primarily functions in cellular processes, contributing to the post-translational modification of proteins through citrullination.
In the regulation of immune responses, PADI4 is implicated in autoimmune diseases such as rheumatoid arthritis, where it contributes to autoantibody generation.
Dysregulation or abnormal expression of PADI4 is associated with autoimmune disorders, particularly rheumatoid arthritis.
There are potential therapeutic implications related to targeting PADI4 in autoimmune disorders, making it a focus for drug development.
Specific substrates of PADI4 include histones and other proteins, impacting cellular processes like gene regulation and signaling pathways.
Customer Reviews (3)
Write a reviewThe minimal variation across different batches enhanced the repeatability of our results.
The product's role in promoting collaboration and teamwork positively impacted the quality of our research.
The product's compatibility with various instruments and techniques promoted teamwork in our interdisciplinary projects.
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