PAH
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Official Full Name
Phenylalanine Hydroxylase
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Overview
Tyrosine hydrolase (TYH) is the enzyme which converts tyrosine to dihydroxyphenylalanine (L-dopa), a precursor of the catecholamine neurotransmitters dopamine, noradrenaline and adrenaline. Tryptophan hydrolase (TRH) is the enzyme that converts 5-hydroxytryptophan to serotonin. TRH can be used as a marker for serotonin as it converts 5-hydroxy-tryptophan to serotonin. Serotonin is rapidly metabolized and is unable to be detected by anti-serotonin antibodies in post mortem tissue. In human tissue that has been formalin-fixed, due to a change in the antigenic determinant of TYH, this product will bind only TRH. The antibody can therefore be used to specifically identify serotonergic neurons in fixed human tissues. Phenylalanine hydrolase (PAH) can be detected in hepatic tissue sections. -
Synonyms
PAH; Phe 4 monooxygenase; Phenylalanine hydrolase; Phenylalanine hydroxylase; PKU 1; PKU; PKU1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Human
- Mouse
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Human cells
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PAH Related Articles
PAH involved in several pathways and played different roles in them. We selected most pathways PAH participated on our site, such as Phenylalanine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phenylalanine metabolism | AOC3;HPDA;HPDB;MIF;GM4952;GOT2A;ALDH3B1;ALDH3A1;HPD |
| Phenylalanine, tyrosine and tryptophan biosynthesis | TAT;PAH;IL4I1;GOT2B;GOT1;GOT2;GOT2A |
| Metabolic pathways | GK2;SUCLA2;HOGA1;B3GNT1;ABO;UGT1A1;CYP2J5;PNLIP;POLR3A |
| Biosynthesis of amino acids | CPS1;GPT2;ALDOCB;PYCR1B;ACY1;PRPS1A;GLULA;PKM2;PFKM |
PAH has several biochemical functions, for example, amino acid binding, cofactor binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAH itself. We selected most functions PAH had, and list some proteins which have the same functions with PAH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| amino acid binding | AGXT;TPH1;TH;OTC;TAT;TDO2;KARS;DDAH1;DPYS |
| cofactor binding | C3;HACL1;TKT;DDO;DAO;PHYH;ASNS;ACLYA;HIF1AN |
| iron ion binding | FAM84B;HBB;C14orf169;CYP2C54;FA2H;CYP2E1;CYP4A10;CYP19A1;P4HA3 |
| phenylalanine 4-monooxygenase activity | PCBD2;PCBD1;PAH |
| protein homodimerization activity | PCYT1A;LRRC41;ADH1;KYNU;KCNH2;MCL1A;GDNFA;PTS;ATPIF1A |
PAH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAH here. Most of them are supplied by our site. Hope this information will be useful for your research of PAH.
RPS24; v-bcl-2; pgm
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, several medications are available to manage the symptoms and slow the progression of PAH.
Understanding the role of proteins in PAH can lead to the development of more targeted and effective treatments, improving the quality of life for patients with PAH.
Yes, certain biomarkers, such as brain natriuretic peptide (BNP) and endothelin-1, can be indicative of PAH.
Research is ongoing in the development of protein-targeted therapies for PAH, but no specific protein-targeted drugs are widely used as of my last update in January 2022.
Protein biomarkers can help in early diagnosis, and monitoring their levels can aid in assessing disease progression and response to treatment.
Customer Reviews (3)
Write a reviewI highly recommend the use of the PAH protein in various experimental applications.
Considering its outstanding performance across multiple assays, I confidently endorse the inclusion of the PAH protein in diverse research studies.
the PAH protein has been successfully utilized in protein electron microscopy structure analysis, providing valuable insights into molecular structures and interactions.
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