pah
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  • Official Full Name
  • Phenylalanine Hydroxylase
  • Background
  • Tyrosine hydrolase (TYH) is the enzyme which converts tyrosine to dihydroxyphenylalanine (L-dopa), a precursor of the catecholamine neurotransmitters dopamine, noradrenaline and adrenaline. Tryptophan hydrolase (TRH) is the enzyme that converts 5-hydroxytryptophan to serotonin. TRH can be used as a marker for serotonin as it converts 5-hydroxy-tryptophan to serotonin. Serotonin is rapidly metabolized and is unable to be detected by anti-serotonin antibodies in post mortem tissue. In human tissue that has been formalin-fixed, due to a change in the antigenic determinant of TYH, this product will bind only TRH. The antibody can therefore be used to specifically identify serotonergic neurons in fixed human tissues. Phenylalanine hydrolase (PAH) can be detected in hepatic tissue sections.
  • Synonyms
  • PAH; Phe 4 monooxygenase; Phenylalanine hydrolase; Phenylalanine hydroxylase; PKU 1; PKU; PKU1
Cat.#:PAH-1318HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAH Protein, His-SUMO-tagged
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Cat.#:PAH-259HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PAH Protein, MYC/DDK-tagged
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Cat.#:PAH-1510HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAH, His-tagged
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Cat.#:PAH-28935THTag:
Source (Host):Species:Human
Product nameRecombinant Human PAH
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Cat.#:PAH-466HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PAH, His tagged
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Cat.#:PAH-467HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PAH, His-tagged
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Cat.#:PAH-469HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PAH, GST-tagged
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Cat.#:PAH-12312MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PAH Protein
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Cat.#:PAH-1083CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PAH
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Cat.#:PAH-10834ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PAH
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Cat.#:PAH-461HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PAH cell lysate
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Cat.#:Kit-0647Tag:
Source (Host):Species:
Product namep-Aminohippuric Acid Assay Kit
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Involved Pathway

PAH involved in several pathways and played different roles in them. We selected most pathways PAH participated on our site, such as Phenylalanine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phenylalanine metabolism
GM4952; ALDH3A1; ALDH1A3; GOT1; TAT; GOT2A; GOT2; MAOB; KEG1; MAOA
Phenylalanine, tyrosine and tryptophan biosynthesis
TAT; GOT2B; GOT2; IL4I1; GOT2A; PAH; GOT1
Metabolic pathways
DHDPSL; KL; NT5C1BA; DCK; ACSL3A; PNP5A; AMDHD1; HYAL2; SDHDA; PLA2G2A
Biosynthesis of amino acids
GOT2A; CBSA; PRPS1; IDH2; PFKMB; ALDOCB; MAT2AL; PGK1; TPI1A; ALDOA

Protein Function

PAH has several biochemical functions, for example, amino acid binding, cofactor binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAH itself. We selected most functions PAH had, and list some proteins which have the same functions with PAH. You can find most of the proteins on our site.
Function
Related Protein
Function amino acid binding
Related Protein TPH1; TPH2; DDC; ASS1; KARS; TAT; TPH1B; DDAH1; DPYS; SHMT2
Function cofactor binding
Related Protein PAH; ASNS; TKT; BIRC5; HIF1AN; UROS; ACLYA; DDO; ME3; ACLY
Function iron ion binding
Related Protein HBAE3; CYP46A1.1; CYP2W1; ALOX15; CYP2P8; CYP27B1; CYP17A2; CYP4X1; CYP2F2; HBA2
Function phenylalanine 4-monooxygenase activity
Related Protein PAH; PCBD2; PCBD1
Function protein homodimerization activity
Related Protein WWTR1; CARS; CSF1R; HMGCL; XPA; ENG; IDH1; SLC9A7; SLC39A13; TGFB1

Interacting Protein

PAH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAH here. Most of them are supplied by our site. Hope this information will be useful for your research of PAH.
RPS24; v-bcl-2; pgm

PAH Related Articles

Meng, XY; Li, YS; et al. An enzyme-linked immunosorbent assay for detection of pyrene and related polycyclic aromatic hydrocarbons. ANALYTICAL BIOCHEMISTRY 473:1-6(2015).
Volkov, AV; Kurmukov, IA; et al. Impact of bosentan therapy on stress-induced pulmonary hypertension in patients with systemic sclerosis. TERAPEVTICHESKII ARKHIV 87:49-56(2015).