paics
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  • Official Full Name
  • phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
  • Background
  • This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • PAICS; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase; PAIS; multifunctional protein ADE2; ADE2H1; AIRC; ADE2; AIR carboxylase; DKFZp781N1372; MGC1343; MGC5024; Phosphoribosylaminoimidazole carboxylase; PUR6_HUMAN; SAICAR synthetase; multifunctional protein ADE2H1
Cat.#:PAICS-135HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAICS, His-tagged
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Cat.#:PAICS-1511HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAICS, His-tagged
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Cat.#:PAICS-12313MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PAICS Protein
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Cat.#:PAICS-4257RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PAICS Protein
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Cat.#:PAICS-7072CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PAICS
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Cat.#:PAICS-9942ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PAICS
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Cat.#:PAICS-3461HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAICS 293 Cell Lysate
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Involved Pathway

PAICS involved in several pathways and played different roles in them. We selected most pathways PAICS participated on our site, such as Biosynthesis of antibiotics, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAICS were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biosynthesis of antibiotics
DAO1; DAO; NME6; LDHAL6B; BPNT1; GALM; ECHS1; SDS; AMDHD2; CYP51A1
Metabolic pathways
CYP11B1; SARDH; DHRS9; PFKMB; MOGAT3; GFPT1; KCNG4; TREH; ST3GAL3; GOT1
Metabolism
AK7A; CPNE7; DHCR7; Gpc2; AZIN1A; AMD2; NDUFAF6; FAM213B; DCT; DDAH2
Metabolism of nucleotides
DGUOK; NUDT18; DCK; ADSSL1; TYMP; AK7; NUDT5; DTYMK; GLRX; ADSL
Purine metabolism
PNP5B; PDE4B; PKMA; PDE6G; APRT; PNP6; POLR2B; GUCY2F; POLR3K; NME7
Purine ribonucleoside monophosphate biosynthesis
PAICS; ADSS; ADSSL1; ADSL
inosine-5-phosphate biosynthesis
PAICS
inosine-5-phosphate biosynthesis II
PAICS

Protein Function

PAICS has several biochemical functions, for example, ATP binding, identical protein binding, phosphoribosylaminoimidazole carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAICS itself. We selected most functions PAICS had, and list some proteins which have the same functions with PAICS. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MYH10; RBM4.3; ATP2C2; ABCB6; MAT2AB; TOR2A; KHK; DNA2; PRPF4BB; GLUD1
Function identical protein binding
Related Protein SOD1; NOXO1; CLDN6; CTSC; ATL2; MYOM1; NUP153; PARK2; KCNRG; ITGA2B
Function phosphoribosylaminoimidazole carboxylase activity
Related Protein PAICS
Function phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Related Protein PAICS
Function protein binding
Related Protein FAM107A; LEO1; DHRS2; ASGR2; MT1X; CDK17; GMDS; GM5506; SRSF3; LLGL1

Interacting Protein

PAICS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAICS here. Most of them are supplied by our site. Hope this information will be useful for your research of PAICS.
FXR2; NUDT18; L3MBTL2; NIF3L1; SGK1; EIF1B; EPB41; TIMP2; MCC

PAICS Related Articles

Duval, N; Luhrs, K; et al. Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: Cellular models of de novo purine biosynthesis deficiency disorders. MOLECULAR GENETICS AND METABOLISM 108:178-189(2013).
Ng, A; Uribe, RA; et al. Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development. DEVELOPMENT 136:2601-2611(2009).