pak7
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  • Official Full Name
  • p21 protein (Cdc42/Rac)-activated kinase 7
  • Background
  • The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described
  • Synonyms
  • PAK7; p21 protein (Cdc42/Rac)-activated kinase 7; PAK5; KIAA1264; MGC26232; OTTHUMP00000030260; p21(CDKN1A)-activated kinase 7; p21-activated kinase 7; p21CDKN1A-activated kinase 7; protein kinase PAK5; serine/threonine-protein kinase PAK7; EC 2.7.11.1
Cat.#:PAK7-382HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAK7, GST-tagged, Active
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Cat.#:PAK7-522HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 7
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Cat.#:PAK7-725HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAK7, GST-His
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Cat.#:PAK7-1515HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK7, GST-tagged
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Cat.#:PAK7-20HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK7
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Cat.#:PAK7-30672THTag:
Source (Host):Species:Human
Product nameRecombinant Human PAK7
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Cat.#:PAK7-4262RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PAK7 Protein
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Cat.#:PAK7-3293RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PAK7 Protein, His-tagged
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Cat.#:PAK7-4283CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PAK7
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Cat.#:PAK7-12211ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PAK7
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Cat.#:PAK7-3452HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAK7 293 Cell Lysate
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Cat.#:PAK7-3453HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAK7 293 Cell Lysate
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Involved Pathway

PAK7 involved in several pathways and played different roles in them. We selected most pathways PAK7 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
STAT5B; MAP2K4; PLCG2; AKT2L; CAMK2D; GSK3AA; RAF1A; MAP2K4A; SHC2; CAMK2D2
Ras signaling pathway
NGFR; FGF9; RASA3; PTPN11; PLD1; NGF; ARF6; RALB; GNGT1; RAB5B
Axon guidance
RGMA; COL9A1A; COL6A3; KCNQ3; EPHB1; PTPRA; PHB; CLTC; SEMA3E; DUSP4
Focal adhesion
THBS4A; HRASB; SRC; ITGB4; VTNA; THBS4; LAMC1; PIK3R5; RAC3; PAK2B
T cell receptor signaling pathway
CD3G; OXSR1A; MAP2K7; MAP3K14; PPP3CB; MAP2K1; CD8B1; MAPK12; NFATC2; PIK3R3
Regulation of actin cytoskeleton
MYL10; PIP4K2B; PIK3CA; RAF1; ABI2; PTK2AB; APC; PDGFAB; ACTN1; LIMK1
Renal cell carcinoma
PAK2; PIK3R3; TGFB3; MAPK1; BRAF; MET; HGF; PIK3CB; KRAS; RAP1B

Protein Function

PAK7 has several biochemical functions, for example, ATP binding, Rac GTPase binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK7 itself. We selected most functions PAK7 had, and list some proteins which have the same functions with PAK7. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein YES1; PGS1; MYO1C; DYRK2; MAP2K2; DYNC2H1; CSNK1E; PIM2; ABCG4B; MYO1E
Function Rac GTPase binding
Related Protein PKN1; CDKL5; NCF2; PAK1; EPS8; SRGAP2; MAP3K11; ARFIP2; ARHGAP4A; RAB7
Function protein serine/threonine kinase activity
Related Protein RIPK3; TNK2; STK39; SNRKA; TRIO; RIOK2; STRC; MAPK4; CSNK1D; TAOK1

Interacting Protein

PAK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK7.
PKM; 4757996; S100A9; S100A7; RPA3; CCDC59; HIGD1A; CDC42; ARRB2