PAM
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Official Full Name
peptidylglycine alpha-amidating monooxygenase
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Overview
This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. -
Synonyms
PAM; peptidylglycine alpha-amidating monooxygenase; peptidyl-glycine alpha-amidating monooxygenase; PAL; peptidyl alpha hydroxyglycine alpha amidating lyase; peptidylglycine alpha hydroxylating monooxygenase; PHM; AMD_HUMAN; Pancreatic peptidylglycine alpha amidating monooxygenase; Peptidyl alpha amidating enzyme; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Peptidylamidoglycolate lyase; Peptidylglycine 2 hydroxylase; Peptidylglycine alpha amidating monooxygenase; OTTHUMP00000158920; OTTHUMP00000158921; OTTHUMP00000158922; OTTHUMP00000158923; OTTHUMP00000222752; OTTHUMP00000227957; peptidylglycine 2-hydroxylase; peptidyl alpha-amidating enzyme; pep;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293F
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PAM Related Articles
PAM involved in several pathways and played different roles in them. We selected most pathways PAM participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PAM has several biochemical functions, for example, L-ascorbic acid binding, copper ion binding, peptidylamidoglycolate lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAM itself. We selected most functions PAM had, and list some proteins which have the same functions with PAM. You can find most of the proteins on our site.
Function | Related Protein |
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L-ascorbic acid binding | P4HA1B;LEPRE1;P4HA3;EGLN2;P4HTM;OGFOD1;LEPREL1;PAM;EGLN3 |
copper ion binding | COX11;LOXL3B;PAM;S100V2;SERPINB1A;SLC11A2;HEPHL1;HEPH;CCS |
peptidylamidoglycolate lyase activity | |
peptidylglycine monooxygenase activity | |
protein binding | OAZ1;TLE3A;CCDC60;CHIC2;ERLEC1;CINP;FECH;APOBEC2A;F2R |
zinc ion binding | TET2;CSRP1A;DUSP12;RSPRY1;PITRM1;TRIM35-1;ZNF622;MORC1;PIAS3 |
PAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAM here. Most of them are supplied by our site. Hope this information will be useful for your research of PAM.
DEDD; PRKAR1A
- Q&As
- Reviews
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Ask a questionCustomer Reviews (3)
Write a reviewWhen employed in Western Blotting experiments, the PAM protein consistently generates sharp and well-defined protein bands, enabling precise visualization and analysis of protein expression.
I am extremely pleased with the quality of the PAM protein as it perfectly fulfills my experimental requirements.
This protein exhibits exceptional purity and reliability, ensuring accurate and reproducible results in my assays.
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