Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

PARD6A

Official Full Name

par-6 family cell polarity regulator alpha
Overview

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Synonyms

PARD6A; par-6 family cell polarity regulator alpha; PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha; partitioning defective 6 homolog alpha; PAR-6 alpha; Tax-interacting protein 40; tax interaction protein 40; partitioning-defective protein 6; partitioning defective-6 homolog alpha; par-6 partitioning defective 6 homolog alpha;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PARD6A-3436HCL	Recombinant Human PARD6A 293 Cell Lysate	HEK293	N/A	Inquiry
Rat	PARD6A-4271R	Recombinant Rat PARD6A Protein	Mammalian Cell	His	Inquiry
Rat	PARD6A-3933R	Recombinant Rat PARD6A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	PARD6A-3933R-B	Recombinant Rat PARD6A Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	PARD6A-3304R	Recombinant Rhesus monkey PARD6A Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	PARD6A-3122R-B	Recombinant Rhesus Macaque PARD6A Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	PARD6A-3122R	Recombinant Rhesus Macaque PARD6A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	PARD6A-5846Z	Recombinant Zebrafish PARD6A	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PARD6A Related Articles

PARD6A involved in several pathways and played different roles in them. We selected most pathways PARD6A participated on our site, such as Rap signaling pathway, Endocytosis, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARD6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Rap signaling pathway	PIK3CG;PIK3CA;Itgam&Itgb2;CDC42;AKT1;FGFR1;PLCG1;CALML3;P2RY1
Endocytosis	EHD1A;GIT1;PARD6B;HLA-C;RAB35;RAB5B;DNM2A;STRUMPELLIN;EHD3
Hippo signaling pathway	BMP2;WNT5A;CCND1;SCRIB;SMAD1;BMP5;WNT2B;PPP2R2D;PPP2R2A
Tight junction	MYL10;PARD3;ACTN2B;SHROOM2;CLDN15A;CTTN;PRKCD;MYL12.1;KRAS

PARD6A has several biochemical functions, for example, GTP-dependent protein binding, Rho GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARD6A itself. We selected most functions PARD6A had, and list some proteins which have the same functions with PARD6A. You can find most of the proteins on our site.

Function	Related Protein
GTP-dependent protein binding	EEA1;PPIAL4A;RAPGEF5;ARFIP2;RAB5B;AP1G1;RASGRP4;AP3B1;RAB38
Rho GTPase binding	DOCK9;INF2;LRRK2;FMNL2;ARHGEF2;DAAM1;ANTXR2A;CSDA;RHOH
protein binding	TMEM86B;FAM3C;TXNL4A;FKBP2;SYNE3;SETMAR;ZNF404;AKAP8L;SPP1
protein kinase C binding	ADD3;PKP2;AVPR1A;NELL2;GRK5;SDC4;HDAC7;PARD3;DACT1
transcription factor binding	CREG1;GATA3;BCOR;TWIST1;PIANP;E2F4;MED25;STK36;EP300

PARD6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARD6A here. Most of them are supplied by our site. Hope this information will be useful for your research of PARD6A.

PRKCI; PRKCZ

Jauregi-Miguel, A; Fernandez-Jimenez, N; et al. Alteration of Tight Junction Gene Expression in Celiac Disease. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 58:762-767(2014).

Lesiak, A; Pelz, C; et al. A Genome-Wide Screen of CREB Occupancy Identifies the RhoA Inhibitors Par6C and Rnd3 as Regulators of BDNF-Induced Synaptogenesis. PLOS ONE 8:-(2013).