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PARK7

  • Official Full Name

    parkinson protein 7

  • Overview

    The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    PARK7; parkinson protein 7; DJ1; DJ-1; HEL-S-67p; protein DJ-1; oncogene DJ1; epididymis secretory sperm binding protein Li 67p; Parkinson disease (autosomal recessive, early onset) 7;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PARK7-115H Active Recombinant Human PARK7, GST-tagged E.coli N/A
Human PARK7-116H Active Recombinant Human PARK7, GST-tagged E.coli N/A
Human PARK7-30783TH Recombinant Human PARK7 N/A
Human PARK7-230H Recombinant Human PARK7 (DJ-1), His-tagged E.coli His
Human PARK7-114H Recombinant Human PARK7, His-tagged E.coli His
Human PARK7-3978H Recombinant Human PARK7 protein, His-tagged E.coli His Met1-Asp189
Human PARK7-231H Recombinant Human PARK7, MYC/DDK-tagged,C13 & N15-labeled HEK293 Myc/DDK
Human PARK7-3432HCL Recombinant Human PARK7 293 Cell Lysate HEK293 N/A
Human PARK7-301131H Recombinant Human PARK7 protein, GST-tagged E.coli GST Met1-Asp189
Human PARK7-4763H Recombinant Human PARK7 protein, GST-tagged E.coli GST 1-188aa
Human PARK7-4764H Recombinant Human PARK7 protein, His-SUMO-tagged E.coli His-SUMO 1-174aa
Human PARK7-3980H Recombinant Human PARK7 Protein (Met1-Asp189), N-His tagged E.coli N-His Met1-Asp189
Human PARK7-2549H Recombinant Human PARK7 Protein, His-tagged E.coli N-His Ala2-Asp189
Human PARK7-4765H Recombinant Human PARK7 protein, His-GST-tagged E.coli His/GST 1-174aa
Human PARK7-1138H Recombinant Human PARK7 protein E.coli N/A 1-188aa
Human PARK7-7991HFL Recombinant Full Length Human PARK7, Flag-tagged Mamanlian cells Flag
Human PARK7-2590H Recombinant Human PARK7 protein E.coli N/A Met1-Asp189
Mouse Park7-34M Recombinant Mouse Park7 protein, His-tagged E.coli His
Mouse PARK7-12363M Recombinant Mouse PARK7 Protein Mammalian Cell His
Mouse Park7-1900M Recombinant Mouse Park7 Protein, His-tagged E.coli N-His Ala2-Asp189
Mouse Park7-4676M Recombinant Mouse Park7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PARK7-6498M Recombinant Mouse PARK7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Park7-1901M Recombinant Mouse Park7 protein, His-tagged E.coli His Met1~Asp189
Mouse PARK7-6498M-B Recombinant Mouse PARK7 Protein Pre-coupled Magnetic Beads HEK293
Rat PARK7-4274R Recombinant Rat PARK7 Protein Mammalian Cell His
Rat PARK7-3936R Recombinant Rat PARK7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Park7-1805R Recombinant Rat Park7 protein, His-tagged E.coli His Met1~Asp189 (Accession # O88767)
Rat PARK7-3936R-B Recombinant Rat PARK7 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PARK7-1472Z Recombinant Zebrafish PARK7 Mammalian Cell His
Chicken PARK7-6154C Recombinant Chicken PARK7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PARK7 Related Articles
  • PARK7 Related Research Area

PARK7 involved in several pathways and played different roles in them. We selected most pathways PARK7 participated on our site, such as Alpha-synuclein signaling, Androgen receptor signaling pathway, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alpha-synuclein signalingCSNK2A1;BLK;KLK6;PARK7;STUB1;FKBP1A;TOR1A
Androgen receptor signaling pathwayRUNX2A;RNF6;RNF4;CDKN1A;PSMC3IP;RANBP9;PARK7;SMARCE1;CTNNB2
Parkinsons diseaseUQCRFS1;SDHB;GNAI1;ATP5D;NDUFA7;NDUFC1;COX7A1;COX4I2;COX6A2
Parkinsons Disease PathwayPARK7;LRRK2;ATXN2;UBE2J2;SYT11
Synaptic Vesicle PathwaySYN3;PARK7;SYP;SYN1;SYN2;STX1B;CPLX2;DNM1L

PARK7 has several biochemical functions, for example, L-dopa decarboxylase activator activity, androgen receptor binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARK7 itself. We selected most functions PARK7 had, and list some proteins which have the same functions with PARK7. You can find most of the proteins on our site.

Function Related Protein
L-dopa decarboxylase activator activity
androgen receptor bindingPIAS2;NCOA4;TCF21;SMARCA4;EP300;RNF14;NSD1;BRCA1;TGFB1I1
copper ion bindingS100V2;AOC3;TYRP1B;CCC2;SOD3A;PAM;LOXL5B;F8;S100A5
NOT core promoter binding
cupric ion binding
cuprous ion binding
cytokine bindingNRP2;CXCR4;TNFRSF11A;CSF1R;IL31RA;IL17F;KITB;Fzd4;CHRD
NOT double-stranded DNA bindingC19orf33;PARK7
enzyme bindingUSP22;MLL5;DNM2;CABYR;KIAA1967;PPARG;GBP1;PARK7;MARCH6
glyoxalase (glycolic acid-forming) activity
glyoxalase III activityPARK7;PDDC1
identical protein bindingGOT2A;MMP9;ATXN10;GUCY2E;TK1;VPS41;ASMT;NELL2;CHEK2
kinase bindingRASGRP3;UBQLN1;CEBPB;BCL10;PARK2;HPCA;WWC3;LDHA;PER1
mRNA bindingPCF11;EIF4A1;NCBP2;TPR;KIAA0020;SNRPC;NUDT16;PARK7;SSB
mercury ion bindingPARK7;P2RX2
oxidoreductase activity, acting on peroxide as acceptorPARK7;CAT
peptidase activityAGBL4;PRSS28;F9A;NPEPPS;USP9;CPD;F2RL1.2;BACE1;MEP1A.1
peroxiredoxin activityPRDX5;PRDX6;PARK7
protein bindingTEKT3;FBXL15;RBFOX2;E2F7;AAAS;HTR1B;KHDC1A;MCC;MELK
protein homodimerization activityMSH2;GPD1C;SMAD4;PVRL3B;ANXA6;PRMT8;UGT1A3;BOKA;TPR
receptor bindingIDH1;DRD1A;WNT4B;MAP7;C3;LRP6;TNFSF14;CSK;MSN
repressing transcription factor bindingHDAC5;TLE4;HMGB1;NFYB;PRDM5;RUNX2;TCF3;KAT5;HHEX
scaffold protein bindingNLGN4Y;KRT5;CHRNA7;HOMER1;MDM2;MAPK3;KCNH2;DSP;PARK7
NOT single-stranded DNA bindingC19orf33;PARK7
small protein activating enzyme binding
superoxide dismutase copper chaperone activityPARK7;CCS;ATP7A
transcription coactivator activityWNT3A;RAP2C;PDLIM1;MED7;MAGED1;MMS19;ATF2;CDK7;RB1
transcription factor bindingRNF222;MLXIPL;FOXC1;NAB1;PITX2;IFI16;NFYC;GATA2;AGTR2
tyrosine 3-monooxygenase activator activity
ubiquitin-like protein conjugating enzyme bindingRNF185;RPS3;PARK7
ubiquitin-specific protease bindingRAD23A;VCP;SART3;PARK7;AMFR;DERL1;BAG6;SYVN1;VPS24

PARK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARK7.

FADD; PYCR1; AR

Saito, Y; et al. Oxidized DJ-1 as a possible biomarker of Parkinson's disease. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 54:138-144(2014).
Chang, LC; Fan, CW; et al. Immunohistochemical Study of the Nrf2 Pathway in Colorectal Cancer: Nrf2 Expression is Closely Correlated to Keap1 in the Tumor and Bach1 in the Normal Tissue. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 21:511-517(2013).
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