pawr
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  • Official Full Name
  • PRKC, apoptosis, WT1, regulator
  • Background
  • The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.
  • Synonyms
  • PAWR; PRKC, apoptosis, WT1, regulator; PRKC apoptosis WT1 regulator protein; par 4; PAR4; WT1-interacting protein; transcriptional repressor PAR4; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response pr
Cat.#:PAWR-19HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PAWR, MYC/DDK-tagged
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Cat.#:PAWR-28664THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PAWR
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Cat.#:PAWR-538HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAWR protein, His & GST-tagged
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Cat.#:PAWR-12389MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PAWR Protein
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Cat.#:PAWR-4282RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PAWR Protein
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Cat.#:PAWR-1532ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PAWR
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Cat.#:PAWR-3420HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAWR 293 Cell Lysate
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Involved Pathway

PAWR involved in several pathways and played different roles in them. We selected most pathways PAWR participated on our site, such as Ceramide signaling pathway, Coregulation of Androgen receptor activity, IL-4 signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAWR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ceramide signaling pathway
CTSD; CRADD; DERL3; EGF; PAWR
Coregulation of Androgen receptor activity
CARM1; KDM4C; SVIL; KDM1A; TGFB1I1; TMF1; TCF4; CTDSP2; KDM3A; MAK
IL-4 signaling Pathway
DOK2; PAWR; HMGA1-RS1; ADRBK2; IL4R.1; SPI1B

Protein Function

PAWR has several biochemical functions, for example, actin binding, enzyme binding, leucine zipper domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAWR itself. We selected most functions PAWR had, and list some proteins which have the same functions with PAWR. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein PHACTR1; SHROOM4; EPB41; SNTB2; FRG1; ABLIM1B; KLHL2; INPPL1; GAS2L3; AVIL
Function enzyme binding
Related Protein P4HB; TNKS2; UGT1A6B; RAD9A; TSPAN5; TULP3; PLCB1; YWHAB; PPP1R3B; ZFP36
Function leucine zipper domain binding
Related Protein CRX; MKL1; NRL; DAPK3; ATF4; ERC1; KCNA3; PAWR; PMF1; DDIT3
Function protein binding
Related Protein TCEB1; SEMG2; ZBTB22; EPS8L1; ZNF335; OCA2; TMEM93; C4BP; PRAME; LDHB
Function protein kinase C binding
Related Protein PRKCB; PARD3; HDAC7A; PDLIM5; TIRAP; DACT1; PAWR; PKP2; HSPB1; HDAC9
Function protein phosphatase 1 binding
Related Protein PHACTR4B; PAWR; PHACTR3B; LILRB2; PPP1R9B; STAU1; SH3RF2; FER; PHACTR1; PPP1R15A
Function transcription corepressor activity
Related Protein TBL1X; SAP30; SKOR1A; TDP2; DNMT3B; NCOR2; ZFPM2; KLF12; UBP1; RUNX1T1

Interacting Protein

PAWR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAWR here. Most of them are supplied by our site. Hope this information will be useful for your research of PAWR.
HSPA5; Spsb2; SPSB1; Spsb4; SPSB4; SPSB2; Spsb1; Kif23