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PCDHGA12

  • Official Full Name

    protocadherin gamma subfamily A, 12

  • Overview

    This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
  • Synonyms

    PCDHGA12; protocadherin gamma subfamily A, 12; cadherin 21 , CDH21; protocadherin gamma-A12; FIB3; fibroblast cadherin FIB3; KIAA0588; PCDH GAMMA A12; Cadherin 21; CDH21; cadherin-21; fibroblast cadherin-3; PCDH-GAMMA-A12;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PCDHGA12-1303HCL Recombinant Human PCDHGA12 cell lysate N/A
Human PCDHGA12-3458H Recombinant Human PCDHGA12 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Pcdhga12-4708M Recombinant Mouse Pcdhga12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PCDHGA12 involved in several pathways and played different roles in them. We selected most pathways PCDHGA12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHGA12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

PCDHGA12 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHGA12 itself. We selected most functions PCDHGA12 had, and list some proteins which have the same functions with PCDHGA12. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingMMP16;PCDH1G32;SYT7;PRKCSH;LTBP3;THBS2;MMP12;HPCA;S100A7A

PCDHGA12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHGA12 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHGA12.

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