PCNA
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Official Full Name
proliferating cell nuclear antigen
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Overview
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008] -
Synonyms
PCNA; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Sf9 Insect Cells
- Yeast
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- HEK293
- HEK293T
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- Insect Cells
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- Mammalian cells
- Sf9 Insect Cell
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PCNA Related Articles
- PCNA Related Research Area
- PCNA Related Signal Pathway
PCNA involved in several pathways and played different roles in them. We selected most pathways PCNA participated on our site, such as DNA replication, Base excision repair, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCNA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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DNA replication | PCNA;GINS2;RFC2;RPA2;RFC5;FEN1;RPA1;POLE;POLA1 |
Base excision repair | HMGB1B;POLE;POLE4;MUTYH;NEIL1;SMUG1;PARP1;POLL;UNG |
Nucleotide excision repair | COPS8;KIAA1530;GTF2H2C_2;POLD2;MNAT1;RBX1;COPS6;COPS5;GTF2H1 |
Mismatch repair | MSH2;RFC2;RPA3;MSH6;RFC4;PCNA;RFC1;MSH3;RFC5 |
Cell cycle | TFDP1;CENPQ;MAU2;CUL1;MND1;SMC1B;CDK2;CDKN1BA;CDC6 |
Hepatitis B | SMAD3;APAF1;NRAS;IFNA10;CASP10;IFNA21;IKBKG;DDX3X;MAPK3 |
HTLV-I infection | CD3D;FDPS;FZD2;TP53INP1;DLG1;PPP3CA;HLA-DQB1;PCNA;PTTG2 |
PCNA has several biochemical functions, for example, DNA polymerase binding, DNA polymerase processivity factor activity, MutLalpha complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCNA itself. We selected most functions PCNA had, and list some proteins which have the same functions with PCNA. You can find most of the proteins on our site.
Function | Related Protein |
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DNA polymerase binding | CDK2AP1;SMARCA4;HMGB1;FANCD2;ACD;RAD51;PCNA;LONP1;FANCI |
DNA polymerase processivity factor activity | TEFM;PCNA |
MutLalpha complex binding | PCNA;TREX1 |
chromatin binding | MCM5;CAPNS2;SOX10;SLC30A9;MED12;HOXD13;RNF20;KDM6B;LHX2 |
damaged DNA binding | PCNA;EP300;RAD18;APEX1;ERCC3;TP53BP1;HMGB1;XPA;TRPC2 |
dinucleotide insertion or deletion binding | |
estrogen receptor binding | PADI2;PHB2;WIPI1;TRIP4;NSD1;CTNNB1;CCDC62;ISL1;ARRB1 |
histone acetyltransferase binding | EPAS1;MTF1;EGR1;GLI3;TRIP4;MYOCD;CEBPB;FOXP3;TRP53 |
identical protein binding | MTSS1;MAPK1IP1;SNX8;GM5077;SCAND1;WRNIP1;GYPA;EPOR;AMELX |
protein binding | UPF1;HYPM;A1CF;SFPQ;TRIM55;GDF7;HBXIP;YTHDC1;ZBTB26 |
purine-specific mismatch base pair DNA N-glycosylase activity | |
receptor tyrosine kinase binding | PITPNM3;ANGPT2A;GNB2L1;SHC3;LRP4;TP53;ANGPT1;FIZ1;PIK3R2 |
PCNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCNA here. Most of them are supplied by our site. Hope this information will be useful for your research of PCNA.
CDKN1A; FEN1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, elevated PCNA levels in tumor tissues are associated with a poorer prognosis in many cancer types.
Mutations in the PCNA gene can lead to DNA repair deficiencies and may be associated with increased cancer risk and poor clinical outcomes.
PCNA is often overexpressed in cancer cells, making it a potential diagnostic marker and a target for cancer therapies.
Yes, some clinical trials are exploring drugs that target PCNA, primarily in the context of cancer treatment.
PCNA acts as a scaffold for various DNA repair proteins, making it crucial for maintaining genomic stability and relevant in DNA repair-based therapies.
Customer Reviews (3)
Write a reviewIn protein electron microscopy structure analysis, PCNA protein proved to be an invaluable tool, allowing for the precise determination of protein structures with remarkable clarity and resolution.
In my ELISA experiments, PCNA protein consistently provided reliable and reproducible results, with high sensitivity and specificity.
I enthusiastically endorse PCNA protein as it delivers exceptional performance in a wide range of applications.
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