pcna
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  • Official Full Name
  • proliferating cell nuclear antigen
  • Background
  • The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PCNA; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein;
Cat.#:PCNA-626HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCNA Protein, MYC/DDK-tagged
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Cat.#:PCNA-174HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Proliferating Cell Nuclear Antigen
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Cat.#:PCNA-175HTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PCNA, His-tagged
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Cat.#:PCNA-536HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Proliferating Cell Nuclear Antigen
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Cat.#:PCNA-110HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCNA Protein, His-tagged
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Cat.#:PCNA-1535HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCNA protein
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Cat.#:PCNA-1579HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCNA, His-tagged
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Cat.#:PCNA-4488HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Proliferating Cell Nuclear Antigen, GST-tagged
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Cat.#:PCNA-4863Tag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCNA protein, His-tagged
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Cat.#:PCNA-4863HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCNA, His-tagged
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Cat.#:PCNA-6999HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PCNA, His tagged
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Cat.#:PCNA-12502MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PCNA Protein
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Cat.#:PCNA-4302RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PCNA Protein
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Cat.#:PCNA-774CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PCNA Protein, His-tagged
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Cat.#:PCNA-3330RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PCNA Protein, His-tagged
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Cat.#:PCNA-5744CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PCNA
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Cat.#:PCNA-8977ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PCNA
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Cat.#:PCNA-1534YTag:
Source (Host):E. coliSpecies:Yeast
Product nameRecombinant Yeast PCNA protein
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Cat.#:PCNA-4489HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Sf9 Insect Cells
Product nameRecombinant Proliferating Cell Nuclear Antigen, His-tagged
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Cat.#:PCNA-500HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PCNA cell lysate
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Involved Pathway

PCNA involved in several pathways and played different roles in them. We selected most pathways PCNA participated on our site, such as DNA replication, Base excision repair, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCNA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA replication
MCM10; MCM3; POLD4; PRIM1; RNASEH2B; RPA2; GINS2; POLE4; SSBP1; POLD1
Base excision repair
POLB; NEIL2; POLD2; APEX1; MBD4; PCNA; OGG1; POLE4; POLE2; XRCC1
Nucleotide excision repair
MCRS1; INO80B; COPS6; TFPT; RPA4; CHD1L; RFC5; RFC4; RAD23AB; GTF2H5
Mismatch repair
MLH3; RFC2; PMS2; POLD2; RPA3; POLD4; MSH3; EXO1; LIG1; RFC4
Cell cycle
UBE2V2; TOP2A; MPEG1.1; BRE; SETA; GORASP2; YWHAE2; CDC23; PSMC3IP; CKAP5
Hepatitis B
CCNE1; IRF7; ELK1; PIK3CD; CASP10; SMAD3; SRC; CCNA1; IFNA5; IFNA2
HTLV-I infection
WNT8B; XBP1; WNT8A; PPP3R1; CD40; TERT; DVL3; HLA-DRA; APC2; POLE2

Protein Function

PCNA has several biochemical functions, for example, DNA polymerase binding, DNA polymerase processivity factor activity, MutLalpha complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCNA itself. We selected most functions PCNA had, and list some proteins which have the same functions with PCNA. You can find most of the proteins on our site.
Function
Related Protein
Function DNA polymerase binding
Related Protein PCNA; CDK2AP1; HMGB1; SMARCA4; RAD51; ACD; FANCI; LONP1; FANCD2
Function DNA polymerase processivity factor activity
Related Protein TEFM; PCNA
Function MutLalpha complex binding
Related Protein PCNA; TREX1
Function chromatin binding
Related Protein ELK1; MSH6; TAL1; ENY2; HIST2H3C1; TTC5; PLAC8; SFPQ; HMGN5; MEN1
Function damaged DNA binding
Related Protein OGG1; NEIL3; XRCC1; TP63; CREBBP; ERCC3; RAD23A; RAD18; POLH; ERCC1
Function dinucleotide insertion or deletion binding
Related Protein PCNA
Function estrogen receptor binding
Related Protein DYX1C1; NSD1; CCDC62; CTNNB1; TRIP4; PHB2; DDX5; HSD17B10; NKX3; PPARGC1A
Function histone acetyltransferase binding
Related Protein MYOCD; KAT2B; GLI3; CREB1; EID1; SP1; TRIM68; TAF7; TAF7L; MEF2A
Function identical protein binding
Related Protein MRI1; PDGFB; HSPB1; MVK; FRS3; ZDHHC17; ADIPOR1; FBXW7; KCNJ10; COL1A1
Function protein binding
Related Protein CTSB; WRAP53; USP17L2; RPL10A; TRAM2; EIF2B3; RAD9A; FAM110A; RDM1; CD99L2
Function purine-specific mismatch base pair DNA N-glycosylase activity
Related Protein PCNA
Function receptor tyrosine kinase binding
Related Protein ANGPT2; PTPN11; ELMO2; HYAL2; TRP53; NCK1; Flt3l; LRP4; PIK3R2; GNB2L1

Interacting Protein

PCNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCNA here. Most of them are supplied by our site. Hope this information will be useful for your research of PCNA.
CDKN1A; FEN1

PCNA Related Articles

Abdel-Latif, M; Sakran, T; et al. Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis. INTERNATIONAL IMMUNOPHARMACOLOGY 24:173-181(2015).
Park, JB; Lee, JS; et al. Adipose tissue-derived mesenchymal stem cells cultured at high cell density express brain-derived neurotrophic factor and exert neuroprotective effects in a 6-hydroxydopamine rat model of Parkinson's disease. GENES & GENOMICS 37:213-221(2015).