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PCNA

  • Official Full Name

    proliferating cell nuclear antigen

  • Overview

    The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
  • Synonyms

    PCNA; proliferating cell nuclear antigen; cyclin; DNA polymerase delta auxiliary protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Sf9 Insect Cells
  • Yeast
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PCNA-536H Recombinant Human Proliferating Cell Nuclear Antigen E.coli N/A
Human PCNA-6999H Recombinant Human PCNA protein, His-tagged Insect Cells His Met1-Ser261
Human PCNA-175H Recombinant Human PCNA, His-tagged Insect Cell N/A
Human PCNA-110H Recombinant Human PCNA Protein, His-tagged E.coli His
Human PCNA-174H Recombinant Human Proliferating Cell Nuclear Antigen Sf9 Insect Cell N/A
Human PCNA-4488H Recombinant Proliferating Cell Nuclear Antigen, GST-tagged Human GST
Human PCNA-4863 Recombinant Human PCNA protein, His-tagged E.coli His Full Length
Human PCNA-1579H Recombinant Human PCNA, His-tagged E.coli His 8-256aa
Human PCNA-4863H Recombinant Human PCNA, His-tagged E.coli His Full Length
Human PCNA-1535H Recombinant Human PCNA protein E.coli N/A
Human PCNA-500HCL Recombinant Human PCNA cell lysate Insect Cell N/A
Human PCNA-1620H-B Recombinant Human PCNA Protein Pre-coupled Magnetic Beads HEK293
Human PCNA-626H Recombinant Human PCNA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PCNA-249HFL Recombinant Full Length Human PCNA Protein, C-Flag-tagged Mammalian cells Flag
Human PCNA-5685H Recombinant Human PCNA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PCNA-1620H Recombinant Human PCNA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PCNA-066H Recombinant Human PCNA Protein E.coli 261
Human PCNA-4814H Recombinant Human PCNA Protein (Met1-Ser261), C-His tagged E.coli C-His Met1-Ser261
Mouse PCNA-12502M Recombinant Mouse PCNA Protein Mammalian Cell His
Mouse Pcna-4715M Recombinant Mouse Pcna Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PCNA-6556M Recombinant Mouse PCNA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PCNA-6556M-B Recombinant Mouse PCNA Protein Pre-coupled Magnetic Beads HEK293
Rat PCNA-4302R Recombinant Rat PCNA Protein Mammalian Cell His
Rat PCNA-3964R-B Recombinant Rat PCNA Protein Pre-coupled Magnetic Beads HEK293
Rat PCNA-3964R Recombinant Rat PCNA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey PCNA-774C Recombinant Cynomolgus PCNA Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey PCNA-518C-B Recombinant Cynomolgus Monkey PCNA Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey PCNA-518C Recombinant Cynomolgus Monkey PCNA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PCNA-3330R Recombinant Rhesus monkey PCNA Protein, His-tagged Mammalian Cell His
Rhesus Macaque PCNA-3148R-B Recombinant Rhesus Macaque PCNA Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PCNA-3148R Recombinant Rhesus Macaque PCNA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sf9 Insect Cells PCNA-4489H Recombinant Proliferating Cell Nuclear Antigen, His-tagged Human His
Yeast PCNA-1534Y Recombinant Yeast PCNA protein E.coli N/A
Zebrafish PCNA-8977Z Recombinant Zebrafish PCNA Mammalian Cell His
Chicken PCNA-5744C Recombinant Chicken PCNA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PCNA Related Articles
  • PCNA Related Research Area
  • PCNA Related Signal Pathway

PCNA involved in several pathways and played different roles in them. We selected most pathways PCNA participated on our site, such as DNA replication, Base excision repair, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCNA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA replicationPCNA;GINS2;RFC2;RPA2;RFC5;FEN1;RPA1;POLE;POLA1
Base excision repairHMGB1B;POLE;POLE4;MUTYH;NEIL1;SMUG1;PARP1;POLL;UNG
Nucleotide excision repairCOPS8;KIAA1530;GTF2H2C_2;POLD2;MNAT1;RBX1;COPS6;COPS5;GTF2H1
Mismatch repairMSH2;RFC2;RPA3;MSH6;RFC4;PCNA;RFC1;MSH3;RFC5
Cell cycleTFDP1;CENPQ;MAU2;CUL1;MND1;SMC1B;CDK2;CDKN1BA;CDC6
Hepatitis BSMAD3;APAF1;NRAS;IFNA10;CASP10;IFNA21;IKBKG;DDX3X;MAPK3
HTLV-I infectionCD3D;FDPS;FZD2;TP53INP1;DLG1;PPP3CA;HLA-DQB1;PCNA;PTTG2

PCNA has several biochemical functions, for example, DNA polymerase binding, DNA polymerase processivity factor activity, MutLalpha complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCNA itself. We selected most functions PCNA had, and list some proteins which have the same functions with PCNA. You can find most of the proteins on our site.

Function Related Protein
DNA polymerase bindingCDK2AP1;SMARCA4;HMGB1;FANCD2;ACD;RAD51;PCNA;LONP1;FANCI
DNA polymerase processivity factor activityTEFM;PCNA
MutLalpha complex bindingPCNA;TREX1
chromatin bindingMCM5;CAPNS2;SOX10;SLC30A9;MED12;HOXD13;RNF20;KDM6B;LHX2
damaged DNA bindingPCNA;EP300;RAD18;APEX1;ERCC3;TP53BP1;HMGB1;XPA;TRPC2
dinucleotide insertion or deletion binding
estrogen receptor bindingPADI2;PHB2;WIPI1;TRIP4;NSD1;CTNNB1;CCDC62;ISL1;ARRB1
histone acetyltransferase bindingEPAS1;MTF1;EGR1;GLI3;TRIP4;MYOCD;CEBPB;FOXP3;TRP53
identical protein bindingMTSS1;MAPK1IP1;SNX8;GM5077;SCAND1;WRNIP1;GYPA;EPOR;AMELX
protein bindingUPF1;HYPM;A1CF;SFPQ;TRIM55;GDF7;HBXIP;YTHDC1;ZBTB26
purine-specific mismatch base pair DNA N-glycosylase activity
receptor tyrosine kinase bindingPITPNM3;ANGPT2A;GNB2L1;SHC3;LRP4;TP53;ANGPT1;FIZ1;PIK3R2

PCNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCNA here. Most of them are supplied by our site. Hope this information will be useful for your research of PCNA.

CDKN1A; FEN1

Abdel-Latif, M; Sakran, T; et al. Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis. INTERNATIONAL IMMUNOPHARMACOLOGY 24:173-181(2015).
Park, JB; Lee, JS; et al. Adipose tissue-derived mesenchymal stem cells cultured at high cell density express brain-derived neurotrophic factor and exert neuroprotective effects in a 6-hydroxydopamine rat model of Parkinson's disease. GENES & GENOMICS 37:213-221(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can PCNA levels in tumor tissues provide prognostic information for cancer patients? 05/18/2021

Yes, elevated PCNA levels in tumor tissues are associated with a poorer prognosis in many cancer types.

Are there any genetic mutations associated with PCNA that impact clinical outcomes? 04/12/2021

Mutations in the PCNA gene can lead to DNA repair deficiencies and may be associated with increased cancer risk and poor clinical outcomes.

How is PCNA protein relevant in cancer diagnosis and treatment? 03/01/2020

PCNA is often overexpressed in cancer cells, making it a potential diagnostic marker and a target for cancer therapies.

Are there any PCNA-targeted therapies currently in clinical trials or use? 03/02/2018

Yes, some clinical trials are exploring drugs that target PCNA, primarily in the context of cancer treatment.

How is PCNA protein involved in DNA repair pathways, and how is this relevant to clinical applications 01/15/2016

PCNA acts as a scaffold for various DNA repair proteins, making it crucial for maintaining genomic stability and relevant in DNA repair-based therapies.

Customer Reviews (3)

Write a review
Reviews
01/04/2023

    In protein electron microscopy structure analysis, PCNA protein proved to be an invaluable tool, allowing for the precise determination of protein structures with remarkable clarity and resolution.

    06/17/2017

      In my ELISA experiments, PCNA protein consistently provided reliable and reproducible results, with high sensitivity and specificity.

      04/07/2016

        I enthusiastically endorse PCNA protein as it delivers exceptional performance in a wide range of applications.

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