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PDF

Official Full Name

peptide deformylase (mitochondrial)
Overview

Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells.
Synonyms

PDF; peptide deformylase (mitochondrial); peptide deformylase, mitochondrial; mitochondrial; DEFM_HUMAN; PDF1A; Peptide deformylase; Polypeptide deformylase; peptide deformylase-like protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PDF-7830H	Recombinant Human PDF, GST-tagged	Wheat Germ	GST	Inquiry
Human	PDF-12H	Recombinant Human PDF protein, His-tagged	E.coli	His	Inquiry
Human	PDF-3338HCL	Recombinant Human PDF 293 Cell Lysate	HEK293	N/A	Inquiry
Human	PDF-89H	Recombinant Human PDF protein, His-tagged	E.coli	His	Inquiry
Rhesus Macaque	PDF-3354R	Recombinant Rhesus monkey PDF Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	PDF-3172R	Recombinant Rhesus Macaque PDF Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	PDF-3172R-B	Recombinant Rhesus Macaque PDF Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	PDF-3411Z	Recombinant Zebrafish PDF	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PDF Related Articles

PDF involved in several pathways and played different roles in them. We selected most pathways PDF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PDF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PDF has several biochemical functions, for example, iron ion binding, peptide deformylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDF itself. We selected most functions PDF had, and list some proteins which have the same functions with PDF. You can find most of the proteins on our site.

Function	Related Protein
iron ion binding	CYP4V8;TYW1;CYP2A7;P4HA2;NOS2A;CYP2D9;LEPREL2;CYP2AA9;CYP1A
peptide deformylase activity

PDF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDF here. Most of them are supplied by our site. Hope this information will be useful for your research of PDF.

Max; Trip11; ssdna_dtdg; SLC33A1; Nek2; Shoc2; Cdc6; SRPR; BAG6; CENPA; RNASEH2B; Rab3gap1; Tnpo1; Cdc23; Oxnad1; SGTB; TSNAX; PARD6B; Smc1a; Smc3

Hobbs, CK; Leung, M; et al. CIG-P: Circular Interaction Graph for Proteomics. BMC BIOINFORMATICS 15:-(2014).

Vazquez, S; Lozano, C; et al. Dengue Specific Immunoglobulins M, A, and E in Primary and Secondary Dengue 4 Infected Salvadorian Children. JOURNAL OF MEDICAL VIROLOGY 86:1576-1583(2014).