pdgfc
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  • Official Full Name
  • platelet derived growth factor C
  • Background
  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.
  • Synonyms
  • PDGFC; platelet derived growth factor C; platelet-derived growth factor C; fallotein; SCDGF; PDGF-C; VEGF-E; spinal cord-derived growth factor; secretory growth factor-like protein; AI647969; 1110064L01Rik
Cat.#:PDGFC-206HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFC, Fc Chimera
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Cat.#:PDGFC-208HTag:His
Source (Host):Species:Human
Product nameRecombinant Human PDGFC, His-tagged
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Cat.#:PDGFC-441HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Platelet Derived Growth Factor C
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Cat.#:PDGFC-699HTag:Met/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFC Protein, Met & His-tagged
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Cat.#:PDGFC-7280HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDGFC, His tagged
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Cat.#:PDGFC-888HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PDGFC
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Cat.#:Pdgfc-8158MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfc protein, His & T7-tagged
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Cat.#:Pdgfc-873MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Pdgfc, Fc tagged
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Cat.#:PDGFC-4338RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDGFC Protein
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Cat.#:PDGFC-1174CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PDGFC Protein, Fc-tagged
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Cat.#:PDGFC-6286CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDGFC
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Cat.#:PDGFC-2872HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFC cell lysate
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Cat.#:PDGFC-429HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDGFC cell lysate
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Cat.#:PDGFC-1836MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PDGFC cell lysate
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Involved Pathway

PDGFC involved in several pathways and played different roles in them. We selected most pathways PDGFC participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFC were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
KIT; GNG10; RAPGEF5; KLK1B4; MRAS; TEK; PLCG1; INSR; FGF8; ETS2
Rap signaling pathway
PRKCB; LPAR2; PRKCA; PRKD2; ACTB; PDGFD; INS; VEGFB; RAC2; IGF1
Cytokine-cytokine receptor interaction
PF4V1; INHBC; IFNGR1; IRX1; IL29; HGF; EDA2R; PDGFRB; ACVR1; CRLF2
Phospholipase D signaling pathway
AGPAT3; Pdgfa&Pdgfb; LPAR5; PPAP2A; SOS1; INS1; PTGFR; AVPR1B; MAP2K2; KITLG
PIK-Akt signaling pathway
LPAR4; PDGFRA; IFNA21; CREB3L1; FGF2; GNB3; IFNA6; PPP2R2B; MTCP1; LAMC1
Focal adhesion
PAK3; MYL2; PIK3R3; PRKCA; CAV1; MYL7; CAPN2A; SRMS; VTNA; PPP1CA
Gap junction
TUBB; PLCB1; ADCY2B; DRD1A; TUBA3B; TUBA7L; PLCB2; ITPR3; PDGFC; HTR2CL1
Regulation of actin cytoskeleton
ARAF; PPP1CAA; FGF6B; ITGAE; PIK3R3; KRAS; MLCK2; Fgf15; PAK7; ITGA1
Prostate cancer
NKX3-1; TP53; HRAS; NOXA1; SMARCD1; BAD; PDGFRA; SMARCC2; GRB2; SPRY1
Melanoma
PIK3CA; FGF5; MITF; MAPK1; FGF21; HRAS; FGF19; FGF9; FGFR1; NRAS
Choline metabolism in cancer
PIK3R1; PPAP2B; DGKQ; PIP5K1A; DGKD; PDGFA; PDGFRA; NRAS; PRKCA; SLC22A1

Protein Function

PDGFC has several biochemical functions, for example, growth factor activity, platelet-derived growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFC itself. We selected most functions PDGFC had, and list some proteins which have the same functions with PDGFC. You can find most of the proteins on our site.
Function
Related Protein
Function growth factor activity
Related Protein GDF3; FGF1B; MANF; GDF15; INHBC; INHBAA; CNTF; VHL; ANGPTL3; FGF12
Function platelet-derived growth factor receptor binding
Related Protein FIGF; PTEN; TYMP; PDGFA; Pdgfa&Pdgfb; PDGFAB; PDGFD; PDGFRA; PDGFRB; ITGA5
Function protein binding
Related Protein NGFRB; MYF5; AP1G2; PTRH2; S100A12; RAP1GAP; UBE2F; Shh; GPR128; ISG15
Function protein homodimerization activity
Related Protein CIDEA; BAK1; GOLGA5; PAFAH1B2; OXCT1; XBP1; MECOM; IZUMO1; GDF6; PYGB

Interacting Protein

PDGFC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFC here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFC.
PDGFRA