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PDHA1

  • Official Full Name

    pyruvate dehydrogenase (lipoamide) alpha 1

  • Overview

    The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PDHA1; pyruvate dehydrogenase (lipoamide) alpha 1; PDHA; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; pyruvate dehydrogenase complex, E1-alpha polypeptide 1; PHE1A; PDHCE1A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDHA1-266H Recombinant Human PDHA1, Gly & Pro tagged Insect Cell GST
Human PDHA1-28668TH Recombinant Human PDHA1 protein, His-tagged E.coli His
Human PDHA1-245H Recombinant Human PDHA1, His-GST tagged Insect Cell His
Human PDHA1-1613H Recombinant Human PDHA1, His-tagged E.coli His 41-390aa
Human PDHA1-001HCL Recombinant Human PDHA1 cell lysate Insect Cell N/A
Human PDHA1-1310H Recombinant Human PDHA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDHA1-825H Recombinant Human PDHA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PDHA1-1635H-B Recombinant Human PDHA1 Protein Pre-coupled Magnetic Beads HEK293
Human PDHA1-1646HFL Recombinant Full Length Human PDHA1 Protein, C-Flag-tagged Mammalian cells Flag
Human PDHA1-1635H Recombinant Human PDHA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PDHA1-4465H Recombinant Human PDHA1 protein, His&Myc-tagged E.coli His&Myc 31-390aa
Human PDHA1-4853H Recombinant Human PDHA1 Protein (Phe30-Ser390), N-His tagged E.coli N-His Phe30-Ser390
Mouse PDHA1-12572M Recombinant Mouse PDHA1 Protein Mammalian Cell His
Mouse Pdha1-4760M Recombinant Mouse Pdha1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PDHA1-6598M Recombinant Mouse PDHA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PDHA1-6598M-B Recombinant Mouse PDHA1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PDHA1-3355R Recombinant Rhesus monkey PDHA1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PDHA1-3173R-B Recombinant Rhesus Macaque PDHA1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PDHA1-3173R Recombinant Rhesus Macaque PDHA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken PDHA1-1918C Recombinant Chicken PDHA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDHA1 Related Research Area

PDHA1 involved in several pathways and played different roles in them. We selected most pathways PDHA1 participated on our site, such as Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDHA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisADH1C;MINPP1A;HK3;ENO1B;ADH2-2;ALDH1A3;ADH1B;GPI;PGAM1B
Citrate cycle (TCA cycle)OGDH;DLST;DLD;IDH2;MDH1AA;OGDHA;SUCLG1;SDHA;FH
Pyruvate metabolismALDH3A2A;PDHA1B;ME2;BRP44;FH;MDH1;SLC16A1;MPC1;ACYP2
Metabolic pathwaysPOLE2;AGK;ARSB;CYP3A7;ADH6;DUT;POLR2G;PTDSS2;ATP6V0E
Carbon metabolismACADS;PSAT1;ADPGK;PGAM1A;PRPS1L1;TPI1B;MTHFR;PKMB;PRPS1
HIF- signaling pathwayHK2;STAT3;RPS6KB2;ARNT;TCEB1;CAMK2A;INS;FLT1;IFNGR2
Central carbon metabolism in cancerLDHA;SLC2A1;PDGFRA;PIK3CD;MAP2K2;FGFR2;PDGFRB;SLC16A3;PIK3CG

PDHA1 has several biochemical functions, for example, pyruvate dehydrogenase (acetyl-transferring) activity, pyruvate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDHA1 itself. We selected most functions PDHA1 had, and list some proteins which have the same functions with PDHA1. You can find most of the proteins on our site.

Function Related Protein
pyruvate dehydrogenase (acetyl-transferring) activityPDHA1B;PDHA1A;PDHA1;PDHA2;PDHB
pyruvate dehydrogenase activityPDHA1;PDHB

PDHA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDHA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDHA1.

PDHB; PDK1; PDP1; USP19; DGKE; WDR20; BABAM1; PRKAB1; ITGB3BP; 15-deoxy-delta(12,14; bosutinib; VCAM1; STAT5A; STAT5B; TEAD3; HDAC6; Hdac6

  • Q&As
  • Reviews

Q&As (5)

Ask a question
What are the symptoms of PDHA1-related disorders? 01/28/2022

Symptoms may include developmental delay, intellectual disability, muscle weakness, and movement disorders.

What are the treatment options for PDHA1-related disorders? 12/01/2020

Treatment may involve dietary modifications, supplements, and supportive therapies to manage symptoms.

Are there any ongoing research efforts related to PDHA1 protein? 07/17/2019

Yes, researchers are studying potential gene therapy approaches and novel treatments for PDHA1-related disorders.

How does the PDHA1 protein impact brain function? 01/05/2018

The PDHA1 protein is critical for supplying energy to the brain, and mutations can lead to neurological impairments.

How does a mutation in the PDHA1 gene affect human health? 12/25/2017

Mutations in the PDHA1 gene can lead to pyruvate dehydrogenase complex deficiency, resulting in neurological and developmental problems.

Customer Reviews (3)

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Reviews
06/27/2020

    Incorporating the PDHA1 protein into your research will not only meet but exceed your expectations, enabling you to advance your scientific discoveries with confidence.

    02/28/2019

      Researchers can leverage the unique properties of the PDHA1 protein to gain insights into its biological functions and its impact on disease mechanisms.

      07/10/2017

        It has been shown to play a crucial role in multiple cellular processes, making it highly valuable for investigations into cell signaling, inflammation, and immune responses.

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