pdpk1
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  • Official Full Name
  • 3-phosphoinositide dependent protein kinase-1
  • Background
  • A hallmark of signal transduction pathways is the reversible phosphorylation of serine and threonine residues within specific sequences, or motifs, in target proteins. Specific signaling motifs include not only sequences that are recognized by protein kin
  • Synonyms
  • PDPK1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; PDK1; PkB kinase; PkB-like 1; PkB kinase like gene 1; PRO0461; MGC20087; MGC35290
Cat.#:PDPK1-448HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDPK1 Protein, His-tagged
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Cat.#:PDPK1-561HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDPK1, GST-tagged
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Cat.#:PDPK1-1891HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human 3-Phosphoinositide Dependent Protein Kinase-1, His-tagged
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Cat.#:PDPK1-1626HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDPK1, His-tagged
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Cat.#:PDPK1-387HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDPK1, His-tagged
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Cat.#:PDPK1-4357RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDPK1 Protein
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Cat.#:PDPK1-1904CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDPK1
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Cat.#:PDPK1-3321HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDPK1 293 Cell Lysate
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Cat.#:PDPK1-3322HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDPK1 293 Cell Lysate
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Involved Pathway

PDPK1 involved in several pathways and played different roles in them. We selected most pathways PDPK1 participated on our site, such as PPAR signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
Scd2; ACSL3; ADIPOQB; Scd1; FABP3; APOC3; OLR1; ACSL4B; SCP2; ACADM
FoxO signaling pathway
MAPK10; PLK4; IL6; PLK1; ATG12; BCL6A; NRAS; NLK; MAPK12B; INS1
Sphingolipid signaling pathway
PPP2R5A; FCER1G; GNAI2; DEGS1; PPP2R2B; MAP3K5; MAPK9; LASS1; BCL2; MAPK1
mTOR signaling pathway
TSC2; VEGFAB; CAB39L; PIK3CG; IKBKB; VEGFA; ULK3; PRKAA2; RPS6KAL; INS2
PIK-Akt signaling pathway
THBS1; RPS6KB2; EIF4E2; ITGB7; IL4R; GH1; HSP90AA1; PGF; PIK3R2; FGF22
AMPK signaling pathway
INS1; PPP2R2C; ADIPOR2; HMGCR; PPP2R5D; TSC1; MLYCD; CPT1A; PFKFB4; PIK3R1
Focal adhesion
PPP1CA; COL2A1A; PDGFA; GRB2B; PIK3R5; PAK3; VCL; PIK3CD; MYLPFB; PGF
T cell receptor signaling pathway
CABIN1; PIK3R3; VAV3; GRAP2; CD8B; CD3D; PTPRC; GRAPA; NFKB1; SOS1
Fc epsilon RI signaling pathway
RAC3; MAPK8; PIK3CA; LAT; MAP2K2; FCER1A; VAV2; IL5; PIK3CG; PRKCA
Neurotrophin signaling pathway
MAPK3; MAPK11; SORT1; PLCG2; IRAK4; SHC2; ABL1; MAPK1; Fasl; AKT1
Insulin signaling pathway
FLOT2; MKNK1; SOCS1; PRKAB1B; CALM3A; SHC3; GRB2; PHKG1B; G6PCA.1; PHKA1
Thyroid hormone signaling pathway
MED4; ACTG1; ITGB3; PFKP; MAP2K1; PRKACA; PLCG2; PIK3R2; ATP1B1; PLCD1
Insulin resistance
RPS6KA1; PPP1CAB; MAPK9; MAPK8; GYS1; NR1H3; SLC2A1; PPARA; RPS6KA2; G6PC2
Aldosterone-regulated sodium reabsorption
MAPK1; HSD11B2; ATP1B4; ATP1B3; INSR; PRKCG; PDPK1; IRS1; SCNN1B; PIK3CD
Toxoplasmosis
HLA-DMB; Toxoplasma Gondii Profilin Family Protein; HLA-DQA1; HLA-DPA1; IRAK1; LAMB3; PIK3CA; PDPK1; SOCS1; LAMB1
Hepatitis C
NFKB1; PIK3CG; PIK3R2; CLDN11; PPP2R1A; GRB2; TP53; IFNA7; MAPK10; PPP2R2C
Proteoglycans in cancer
THBS1; WNT9A; TWIST2; MMP9; SLC9A1; GPC1; WNT8B; PRKCB; PIK3R3; CAMK2B
Endometrial cancer
TCF7; GSK3B; CDH1; PIK3R5; SOS1; CTNNA2; PIK3R1; ERBB2; TRP53; KRAS
Prostate cancer
EP300; NFKB1; GSTP1; MTOR; SRD5A2; PTEN; ARID1A; RAF1; NRAS; SPRY1
Non-small cell lung cancer
ERBB2; PLCG1; FHIT; EML4; AKT1; RXRG; PIK3R1; RARB; MAP2K2; TP53
Choline metabolism in cancer
PIP5K1A; PRKCA; SLC22A2; PDGFD; SLC22A1; TSC2; SLC5A7; PDGFC; RAC2; SLC22A3

Protein Function

PDPK1 has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase activity, ATP binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDPK1 itself. We selected most functions PDPK1 had, and list some proteins which have the same functions with PDPK1. You can find most of the proteins on our site.
Function
Related Protein
Function 3-phosphoinositide-dependent protein kinase activity
Related Protein PDPK1; ALPK2
Function ATP binding
Related Protein SBK1; HSPA14; NLRX1; NME3; NMRK2; PIK3CD; ABCC9; SYN2B; EIF2AK1; UBE2L3A
Function insulin receptor binding
Related Protein DOK3; SNX1; IGF1R; DOK6; INS2; SNX4; PTPN1; FRS2; PHIP; SLC2A2
Function phospholipase activator activity
Related Protein ARHGAP6; CCL3; APOC2; GM2A; CCL5; CCL8; PDPK1
Function phospholipase binding
Related Protein CALM2; ARHGAP6; CALM3; SERPINB1A; NEFL; PTPN11; SELE; LMNB1; CALM1; DGKQ
Function protein binding
Related Protein GEMIN7; RHOB; IL12B; PLEKHA1; TRIM24; KLC4; WDHD1; EFCAB12; FOXD3; SMU1
Function protein kinase binding
Related Protein PIH1D1; EMP2; FER; SPDYE2; RCC2; RPS6; RPTOR; PTK2; TELO2; DNM2
Function protein serine/threonine kinase activity
Related Protein IRAK2; BMPR2A; PIM1; ICK; SBK1; TP53RK; VPRBP; MAPK12; TNK2; PIM3

Interacting Protein

PDPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDPK1.
AKT1; YWHAQ; PPP2R2B; APBB3; CSK; SGK1; PTPRC

PDPK1 Related Articles

Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
Wong, VVT; Nissom, PM; et al. Zinc as an insulin replacement in hybridoma cultures. BIOTECHNOLOGY AND BIOENGINEERING 93:553-563(2006).