pdpk1
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  • Official Full Name
  • 3-phosphoinositide dependent protein kinase-1
  • Background
  • A hallmark of signal transduction pathways is the reversible phosphorylation of serine and threonine residues within specific sequences, or motifs, in target proteins. Specific signaling motifs include not only sequences that are recognized by protein kin
  • Synonyms
  • PDPK1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; PDK1; PkB kinase; PkB-like 1; PkB kinase like gene 1; PRO0461; MGC20087; MGC35290
Cat.#:PDPK1-448HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDPK1 Protein, His-tagged
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Cat.#:PDPK1-561HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDPK1, GST-tagged
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Cat.#:PDPK1-1891HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human 3-Phosphoinositide Dependent Protein Kinase-1, His-tagged
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Cat.#:PDPK1-1626HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDPK1, His-tagged
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Cat.#:PDPK1-387HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDPK1, His-tagged
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Cat.#:PDPK1-4357RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDPK1 Protein
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Cat.#:PDPK1-1904CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDPK1
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Cat.#:PDPK1-3321HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDPK1 293 Cell Lysate
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Cat.#:PDPK1-3322HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDPK1 293 Cell Lysate
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Involved Pathway

PDPK1 involved in several pathways and played different roles in them. We selected most pathways PDPK1 participated on our site, such as PPAR signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDPK1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
Scd1; FABP1; SLC27A5; GK; CYP4A14; ACSL4; ADIPOQ; FABP1A; SLC27A2; FABP3
FoxO signaling pathway
PIK3R3A; PLK4; PRKAB1A; PTEN; CCNB2; HOMER1; TNFSF10; PLK2; MAPK12; GRB2B
Sphingolipid signaling pathway
FCER1G; FYN; PPP2R5E; RHOA; GNAI1; MAPK3; TRAF2; PLCB4; PDPK1; MAP2K2
mTOR signaling pathway
RRAGCB; INS2; PIK3CD; PIK3R1; PRKCBB; RPS6KB1; RRN3; EIF4EA; STK11; RPS6
PIK-Akt signaling pathway
MET; ANGPT1; YWHAB; ITGA2B; IGF1; FGF2; LAMA1; KRAS; ITGA6; BCL2
AMPK signaling pathway
RPS6KB1; PIK3CG; PPP2R2D; PRKAA2; PDPK1; PFKL; GYS2; FBP1; PPP2R5C; CREB3L3
Focal adhesion
PTENA; HGF; COL27A1B; PPP1R12A; BCAR1; COL5A1; FLNC; CAV1; RAC1; PPP1CAB
T cell receptor signaling pathway
RELA; CARD11; DLG1; MAP2K1; SHB; CBLB; FOS; MAP2K2; MAPK3; RAF1
Fc epsilon RI signaling pathway
KRAS; SYK; VAV2; IL3; FCER1G; PIK3R2; PIK3CA; HRAS; AKT1; MAPK11
Neurotrophin signaling pathway
PTPN11; PIK3R1; PIK3CA; TRAF6; MAPK8; AKT2; PSEN1; ARHGDIG; NFKBIE; SH2B1
Insulin signaling pathway
TRIP10; PHKG1A; CALM4; MAPK8A; PCK1; INSRB; PRKAR1B; FLOT1; HK2; FBP1
Thyroid hormone signaling pathway
SLC16A2; PLCD4; RXRA; ATP1B4; MED30; PIK3R1; PFKP; SLC2A1; FOXO1; MAPK1
Insulin resistance
SLC27A1A; FOXO1B; PPARA; PRKCZ; PIK3CG; CREB1A; PRKAA1; PPARGC1B; IL6; GSK3B
Aldosterone-regulated sodium reabsorption
IGF1; ALPHA-ENAC; SCNN1B; FXYD4; HSD11B2; PIK3R5; ATP1B4; MAPK3; SCNN1G; ATP1A2
Toxoplasmosis
IL10RB; LAMB1; LAMA5; STAT1; IL12A; MAP2K6; HSPA1A; CYCS; BIRC3; TLR4
Hepatitis C
HRAS; MAPK8; RNASEL; IRF1; CLDN10; IFNA21; NFKBIA; PIAS1; TYK2; PPP2R2A
Proteoglycans in cancer
WNT7B; ERBB3; GAB1; ITGB1; PPP1CA; PRKACB; PIK3R3; PTPN11; FASLG; RHOA
Endometrial cancer
MAPK3; CTNNA3; PIK3CB; NRAS; MAP2K2; CTNNA2; MAPK1; GRB2; RAF1; ILK
Prostate cancer
AKT2; ARAF; NDRG1; CREB3L3; PIK3CG; MAP4K1; NKX3-1; CCND1; KRAS; MDM2
Non-small cell lung cancer
PLCG2; PIK3CD; CASP9; ALK; RXRA; PIK3CA; ARAF; TRP53; RB1; KRAS
Choline metabolism in cancer
PRKCA; DGKB; PIK3CB; FOS; DGKE; PDPK1; SOS1; RAF1; MTOR; SLC22A1

Protein Function

PDPK1 has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase activity, ATP binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDPK1 itself. We selected most functions PDPK1 had, and list some proteins which have the same functions with PDPK1. You can find most of the proteins on our site.
Function
Related Protein
Function 3-phosphoinositide-dependent protein kinase activity
Related Protein PDPK1; ALPK2
Function ATP binding
Related Protein CHKB; CSNK1E; SYK; TPX2; NLRP4C; ENTPD8; DDX31; UBE2H; NUBP1; ERCC2
Function insulin receptor binding
Related Protein FRS2A; FRS3; PIK3R1; PDPK1; DOK1; LMBRD1; DOK3; PTPN11; SNX4; DOK5
Function phospholipase activator activity
Related Protein CCL3; APOC2; CCL8; CCL5; PDPK1; GM2A; ARHGAP6
Function phospholipase binding
Related Protein PARK2; PTPN11; APOC2; CALM1; SNCA; DGKQ; CALM2; SELE; WAS; CALM3
Function protein binding
Related Protein ZMYM4; TRPV6; SRRT; GET4; CHD1; KLHL22; STK4; TRAF6; MEOX2; COPS6
Function protein kinase binding
Related Protein PARP1; CD24; ZBTB4; IBTK; CDK5; TPX2; GATA6; TRIM5; CDK5RAP1; B4GALT1
Function protein serine/threonine kinase activity
Related Protein STK38L; VRK2; GM4922; PRKD1; PDIK1L; SYK; IKBKB; ACVR1B; MAPK4; MARK3

Interacting Protein

PDPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDPK1.
AKT1; YWHAQ; PPP2R2B; APBB3; CSK; SGK1; PTPRC

PDPK1 Related Articles

Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
Wong, VVT; Nissom, PM; et al. Zinc as an insulin replacement in hybridoma cultures. BIOTECHNOLOGY AND BIOENGINEERING 93:553-563(2006).