pdpk1
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  • Official Full Name
  • 3-phosphoinositide dependent protein kinase-1
  • Background
  • A hallmark of signal transduction pathways is the reversible phosphorylation of serine and threonine residues within specific sequences, or motifs, in target proteins. Specific signaling motifs include not only sequences that are recognized by protein kin
  • Synonyms
  • PDPK1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; PDK1; PkB kinase; PkB-like 1; PkB kinase like gene 1; PRO0461; MGC20087; MGC35290
Cat.#:PDPK1-448HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDPK1 Protein, His-tagged
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Cat.#:PDPK1-561HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDPK1, GST-tagged
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Cat.#:PDPK1-1891HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human 3-Phosphoinositide Dependent Protein Kinase-1, His-tagged
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Cat.#:PDPK1-1626HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDPK1, His-tagged
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Cat.#:PDPK1-387HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDPK1, His-tagged
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Cat.#:PDPK1-4357RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDPK1 Protein
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Cat.#:PDPK1-1904CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDPK1
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Cat.#:PDPK1-3321HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDPK1 293 Cell Lysate
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Cat.#:PDPK1-3322HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDPK1 293 Cell Lysate
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Involved Pathway

PDPK1 involved in several pathways and played different roles in them. We selected most pathways PDPK1 participated on our site, such as PPAR signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDPK1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
SLC27A1A; ACSL4B; ACSL4A; AQP7; ADIPOQ; SLC27A2; SLC27A5; ACSL5; ACOX1; PPARAB
FoxO signaling pathway
RAG2; CDKN2D; HOMER1; GABARAPL2; HOMER2; IRS2; MAPK12; TGFBR2; PRKAB2; SOD2
Sphingolipid signaling pathway
FYN; DEGS1; TRAF2; MAPK8; CERS4; PPP2R2B; TNFRSF1A; PPP2CB; ROCK1; SMPD2
mTOR signaling pathway
INS2; STK11; TSC1; PIK3CG; AKT1; RPS6KB1B; PIK3CD; PDPK1; ULK3; AKT3A
PIK-Akt signaling pathway
HSP90AB1; FGFR3; LAMC1; GNB4; PDGFRA; PIK3CA; PGF; GNG13; CREB3L2; IFNAR1
AMPK signaling pathway
RAB11B; PIK3CB; INSR; RPS6KB2; PRKAB1; PFKM; PIK3CA; PPP2CB; PPARGC1A; PPP2R2B
Focal adhesion
PPP1CAB; PPP1CBL; FLT4; PTEN; PIK3CG; COL1A1; SRMS; MYL10; PRKCBB; ARHGAP35
T cell receptor signaling pathway
NFKBIE; ICOS; MAPK13; VAV1; NCK1; TEC; CBLB; MAPK9; LCK; RELA
Fc epsilon RI signaling pathway
MAP2K6; IL5; MAPK12; SYK; PLA2G4C; GRB2; IL3; PLA2G4B; MAP2K2; INPP5D
Neurotrophin signaling pathway
MAP3K1; AKT1; MAP3K3; MAPK10; MATK; PLCG1; MAPK1; PIK3CA; NGF; RPS6KA2
Insulin signaling pathway
HRASA; PRKAB1B; PYGM; SREBF1; PPP1R3C; PPP1R3CA; PPP1CAB; CALM2; CALML5; EIF4E1C
Thyroid hormone signaling pathway
PIK3R5; SRC; MED30; PLCB1; SLC2A1; PRKCA; NOTCH3; MAPK3; PRKACB; ATP1B1
Insulin resistance
CREB3L2; AKT3A; PRKCQ; PPP1CB; ACACB; RPS6KA1; RPS6KA3A; PIK3CA; PPARGC1B; PRKAB1A
Aldosterone-regulated sodium reabsorption
ATP1B1; INS1; ATP1B4; INS; INS2; PIK3R3; KCNJ1; PRKCB; PDPK1; FXYD2
Toxoplasmosis
ITGB1; IFNGR2; H2-AA; PIK3R3; MAPK3; BIRC7; HLA-DRB1; MAPK10; HSPA1A; HSPA8
Hepatitis C
IFNA2; CLDN9; CLDN1; RNASEL; TYK2; TRADD; IKBKG; RXRA; CLDN11; MAPK1
Proteoglycans in cancer
CAMK2B; ERBB3; WNT2B; WNT5B; ITGB1; ANK1; PRKACA; PPP1CB; MAPK1; IGF1
Endometrial cancer
AKT1; MAP2K1; APC2; CTNNA2; PIK3CB; ILK; APC; PTEN; PDPK1; CCND1
Prostate cancer
SOS1; MTOR; CREB3L2; SMARCA4; PIK3CG; ATF4; SMARCD1; SPINK1; FGFR1; PDGFD
Non-small cell lung cancer
PIK3R2; GRB2; RASSF1; PRKCB; TGFA; MAP2K2; PIK3CG; EML4; NRAS; TRP53
Choline metabolism in cancer
MAPK1; GRB2; PPAP2B; SLC5A7; CHKB; MTOR; WAS; PLA2G4F; RPS6KB1; DGKQ

Protein Function

PDPK1 has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase activity, ATP binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDPK1 itself. We selected most functions PDPK1 had, and list some proteins which have the same functions with PDPK1. You can find most of the proteins on our site.
Function
Related Protein
Function 3-phosphoinositide-dependent protein kinase activity
Related Protein PDPK1; ALPK2
Function ATP binding
Related Protein DDX47; MCM3; BMPR1B; UBE2J2; ROCK2A; CKMT1A; KCNJ8; RUNX3; ENPP1; VSIG8B
Function insulin receptor binding
Related Protein FRS3; INS1; IGF2; DOK4; IRS4; SHC1; DOK2; INS; DOK5; ENPP1
Function phospholipase activator activity
Related Protein CCL8; GM2A; ARHGAP6; APOC2; CCL5; PDPK1; CCL3
Function phospholipase binding
Related Protein CALM3; CALM2; Pla2r1; ARHGAP6; SELE; CALM1; PARK2; SERPINB1A; DGKQ; APOC2
Function protein binding
Related Protein DGCR8; RPRD1A; TTC9C; PDIK1L; GTF2H3; LAMA1; TTYH2; FSD2; ERCC6L; ACY1
Function protein kinase binding
Related Protein CCNY; GATA4; SHC1; MLKL; PRKAG1; PLK1S1; GCSAM; PRKAG2; PFKFB2; CDK5
Function protein serine/threonine kinase activity
Related Protein ROCK2B; PRKCBA; MAPK13; IRAK3; TTN; NIM1K; SBK1; STK38; IRAK4; CDK11B

Interacting Protein

PDPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDPK1.
AKT1; YWHAQ; PPP2R2B; APBB3; CSK; SGK1; PTPRC

PDPK1 Related Articles

Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
Wong, VVT; Nissom, PM; et al. Zinc as an insulin replacement in hybridoma cultures. BIOTECHNOLOGY AND BIOENGINEERING 93:553-563(2006).