pdpk1
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  • Official Full Name
  • 3-phosphoinositide dependent protein kinase-1
  • Background
  • A hallmark of signal transduction pathways is the reversible phosphorylation of serine and threonine residues within specific sequences, or motifs, in target proteins. Specific signaling motifs include not only sequences that are recognized by protein kin
  • Synonyms
  • PDPK1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; PDK1; PkB kinase; PkB-like 1; PkB kinase like gene 1; PRO0461; MGC20087; MGC35290
Cat.#:PDPK1-448HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDPK1 Protein, His-tagged
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Cat.#:PDPK1-561HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDPK1, GST-tagged
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Cat.#:PDPK1-1891HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human 3-Phosphoinositide Dependent Protein Kinase-1, His-tagged
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Cat.#:PDPK1-1626HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDPK1, His-tagged
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Cat.#:PDPK1-387HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDPK1, His-tagged
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Cat.#:PDPK1-4357RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDPK1 Protein
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Cat.#:PDPK1-1904CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDPK1
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Cat.#:PDPK1-3321HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDPK1 293 Cell Lysate
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Cat.#:PDPK1-3322HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDPK1 293 Cell Lysate
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Involved Pathway

PDPK1 involved in several pathways and played different roles in them. We selected most pathways PDPK1 participated on our site, such as PPAR signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDPK1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
ACOX2; ACSBG2; FABP4; CYP4A12A; OLR1; APOA1; PPARAB; PDPK1; LPL; APOA2
FoxO signaling pathway
IRS1; IKBKB; PRKAG2A; PRKAG1; IL6; CCND1; KLF2; FOXO1B; PRKAA2; GABARAPL1
Sphingolipid signaling pathway
PPP2R5B; MAPK9; SGMS1; PPP2R5D; ROCK1; FCER1G; MAPK3; LASS4; PPP2R2A; PIK3CG
mTOR signaling pathway
RPS6KA1; EIF4E1B; PRKCG; STRADA; HIF1AB; RPS6KA2; STK11; TSC1; INS1; PRKCBB
PIK-Akt signaling pathway
PIK3CA; Ifna11; GNG12; PIK3CD; COL4A1; IL4; IFNA16; TCL1B4; PHLPP1; ITGA6
AMPK signaling pathway
CPT1B; G6PC; PFKFB4; TSC2; PPP2R5E; CAB39; GYS2; PFKL; PIK3CG; PIK3R1
Focal adhesion
COL6A1; COL5A2A; CAV2; LAMA3; BADB; COL2A1B; MAPK8; ACTB2; COL2A1A; VASPA
T cell receptor signaling pathway
VAV1; NFKB1; GSK3B; VAV2; MAP2K2; CD8B1; CD3E; GRAP2; MAPK12; SOS1
Fc epsilon RI signaling pathway
MAP2K6; HRAS; AKT2; SYK; NRAS; GAB2; MAPK12; MAPK10; INPP5D; MAPK8
Neurotrophin signaling pathway
MAP3K5; BRAF; HRAS; NFKB1; BAX; RELA; SHC4; ABL1; CAMK2B; IKBKB
Insulin signaling pathway
RPS6KB2; MAP2K2; ACACB; PIK3R2; PPP1R3A; CALM1A; KRAS; TRIP10A; CALM2A; PRKACBA
Thyroid hormone signaling pathway
THRB; PIK3CB; PRKACB; ATP1A4; MED13; RXRG; SLC16A2; KRAS; MED17; STAT1
Insulin resistance
GFPT1; CREB3L3; PRKAA1; MLXIPL; RPS6KA6; PDPK1; RPS6KA2; MAPK8B; TNF; PIK3CA
Aldosterone-regulated sodium reabsorption
HSD11B2; PIK3CD; IGF1; ATP1B4; PRKCG; ATP1A4; FXYD2; ATP1A2; PRKCB; ATP1B1
Toxoplasmosis
CD40LG; Toxoplasma Gondii Major Surface Antigen P30; LAMA1; ITGB1; TLR2; HLA-DQA2; PIK3R5; MAPK1; IL10RA; PIK3R2
Hepatitis C
RNASEL; MAPK3; IKBKB; PPP2R2C; EIF2AK2; NRAS; CLDN10; MAPK10; OAS3; PIK3R3
Proteoglycans in cancer
HSPG2; ITGB1; RHOA; FLNC; WNT11; TIMP3; TP53; CDC42; Fasl; WNT2
Endometrial cancer
CCND1; PIK3CD; TCF7; TRP53; HRAS; CDH1; MAPK1; APC2; PTEN; TCF7L2
Prostate cancer
BCL2; SMARCC2; Ar; NFKB1; CCNE2; PDGFC; IGF1; PIK3CB; HSP90AB1; AKT2
Non-small cell lung cancer
FOXO3; MAPK3; BAD; MAP2K2; EML4; PLCG2; MAP2K1; PIK3R5; PRKCB; HRAS
Choline metabolism in cancer
DGKG; AKT2; DGKD; TSC2; CHKA; PDPK1; HIF1A; GRB2; PIP5K1B; WAS

Protein Function

PDPK1 has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase activity, ATP binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDPK1 itself. We selected most functions PDPK1 had, and list some proteins which have the same functions with PDPK1. You can find most of the proteins on our site.
Function
Related Protein
Function 3-phosphoinositide-dependent protein kinase activity
Related Protein ALPK2; PDPK1
Function ATP binding
Related Protein NSF; EPHA2; GUCY2F; UCK2; MYH11A; HLCS; CCT5; PIK3C3; LONP1; MAP4K6
Function insulin receptor binding
Related Protein DOK1B; SNX2; FRS2B; INSL3; DOK3; PIK3R1; IRS1; IGF1; FRS3; INS1
Function phospholipase activator activity
Related Protein ARHGAP6; GM2A; APOC2; CCL3; CCL5; PDPK1; CCL8
Function phospholipase binding
Related Protein SELE; CALM1; DGKQ; CALM2; PARK2; APOC2; PTPN11; SERPINB1A; WAS; SNCA
Function protein binding
Related Protein MLLT1; SUSD2; MED16; CBL; WFDC9; COL23A1; PAGE1; NRAP; TGFB1; POLDIP3
Function protein kinase binding
Related Protein LIMS1; VRK2; RACGAP1; TRIM6; SPAG16; TENC1; SLC12A7; TICAM1; VDAC1; NEK9
Function protein serine/threonine kinase activity
Related Protein SGK1; PRKCZ; TLK1B; TP53RK; MYO3A; CSNK1G1; BMPR1A; MAP4K6; CASK; MARK3

Interacting Protein

PDPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDPK1.
AKT1; YWHAQ; PPP2R2B; APBB3; CSK; SGK1; PTPRC

PDPK1 Related Articles

Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
Wong, VVT; Nissom, PM; et al. Zinc as an insulin replacement in hybridoma cultures. BIOTECHNOLOGY AND BIOENGINEERING 93:553-563(2006).