PELI3
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Official Full Name
pellino homolog 3 (Drosophila)
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Overview
The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PELI3; pellino homolog 3 (Drosophila); E3 ubiquitin-protein ligase pellino homolog 3; MGC35521; E3 ubiquitin protein ligase pellino homolog 3; PEL 13; PELI3_HUMAN; Pellino 3; Pellino 3 alpha; Pellino-3; Protein pellino homolog 3;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PELI3 involved in several pathways and played different roles in them. We selected most pathways PELI3 participated on our site, such as Activated TLR4 signalling, Cytokine Signaling in Immune system, IRAK1 recruits IKK complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with PELI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated TLR4 signalling | CREB1;TIRAP;CREB1B;DUSP4;DHX9;MAPKAPK2B;TAB1;S100A12;PELI1 |
| Cytokine Signaling in Immune system | SPNA1;WDR83;SPRED3;FGF20A;IFIT14;PELI2;SPNA2;SAMHD1;NUPL2 |
| IRAK1 recruits IKK complex | PELI3;PELI1;PELI2 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | PELI2;PELI1;PELI3 |
| Immune System | ACTR2B;CD300LB;CD300LD;CTSLL;TLR10;WSB1;KIF20A;AMICA1;KIR3DS1 |
| Innate Immune System | NLRP4B;POLR3GLA;MAP3K8;MGC174155;MYO1C;PCBP2;DEFA6;DEFB121;DEFB4A |
| Interleukin-1 signaling | TNIP2;IL1RN;NOD1;PELI2;PELI1;IRAK3;PELI3 |
| MyD88 cascade initiated on plasma membrane | ALCAMB;S100B;CHST13;DHX9;TNIP2;PELI1;PELI2;DUSP3B;PELI3 |
PELI3 has several biochemical functions, for example, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PELI3 itself. We selected most functions PELI3 had, and list some proteins which have the same functions with PELI3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | UBE2I;PJA1;HECTD3;RNF152;SYVN1;CNOT4;C12orf51;CBLB;TRIM9 |
| protein binding | DTNB;PYGO1;Acr;RELB;MAPK10;MCM7;SKAP2;LIN37;STAP2 |
PELI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PELI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PELI3.
PIK3R3; IRAK1; TRAF6
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