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PEX6

  • Official Full Name

    peroxisomal biogenesis factor 6

  • Overview

    This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6.
  • Synonyms

    PEX6; peroxisomal biogenesis factor 6; peroxisome biogenesis factor 6; PAF 2; PXAAA1; PAF2; Peroxin 6; Peroxisomal AAA type ATPase 1; peroxin-6; peroxisomal-type ATPase 1; peroxisome assembly factor 2; peroxisomal AAA-type ATPase 1; PAF-2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Arabidopsis thaliana
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PEX6-686H Recombinant Human PEX6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PEX6-1067H Recombinant Human PEX6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse Pex6-4801M Recombinant Mouse Pex6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PEX6-4387R Recombinant Rat PEX6 Protein Mammalian Cell His
Rat PEX6-4047R Recombinant Rat PEX6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PEX6-4047R-B Recombinant Rat PEX6 Protein Pre-coupled Magnetic Beads HEK293
Arabidopsis thaliana PEX6-1653A Recombinant Arabidopsis thaliana PEX6, His-tagged E.coli His 1-350aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PEX6 Related Articles

PEX6 involved in several pathways and played different roles in them. We selected most pathways PEX6 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PeroxisomeGNPAT;PEX5L;SOD2;PEX26;PEX2;PECR;FAR2;ACSL4;ACOX2

PEX6 has several biochemical functions, for example, ATP binding, ATPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEX6 itself. We selected most functions PEX6 had, and list some proteins which have the same functions with PEX6. You can find most of the proteins on our site.

Function Related Protein
ATP bindingGTF2F2A;STK10;PRKACAB;HELQ;OXSR1B;TOP2A;FGFR1A;ACTB2;HSPA4B
ATPase activityPSMC5;ABCF1;TOR1A;KIF15;VWA8;HSPA1B;ABCB6A;PEX6;ATAD1
protein bindingEPB49;BAIAP2L1;NCKIPSD;MTSS1;APOO;SYNPO2L;SYNJ2BP;CKMT1;STAU2

PEX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEX6.

Miyata, N; Okumoto, K; et al. AWP1/ZFAND6 Functions in Pex5 Export by Interacting with Cys-Monoubiquitinated Pex5 and Pex6 AAA ATPase. TRAFFIC 13:168-183(2012).
Hashiguchi, N; Kojidani, T; et al. Peroxisomes are formed from complex membrane structures in PEX6-deficient CHO cells upon genetic complementation. MOLECULAR BIOLOGY OF THE CELL 13:711-722(2002).
Baker, A; Charlton, W; et al. Biochemical and molecular approaches to understanding protein import into peroxisomes. BIOCHEMICAL SOCIETY TRANSACTIONS 28:499-504(2000).
Faber, KN; Heyman, JA; et al. Two AAA family peroxins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes. MOLECULAR AND CELLULAR BIOLOGY 18:936-943(1998).
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