pfkl
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  • Official Full Name
  • phosphofructokinase, liver
  • Background
  • Phosphofructokinase (PFK) catalyzes the phosphorylation of fructose-6-phosphate in glycolysis. There are three isozymes: muscle-type, liver-type, and platelet-type. The liver-type PFK (PFKL) is the predominant subunit of PFK found in the liver . Research
  • Synonyms
  • PFKL; phosphofructokinase, liver; 6-phosphofructokinase, liver type; phosphohexokinase; phosphofructokinase 1; liver-type 1-phosphofructokinase; phosphofructo-1-kinase isozyme B; PFK-B; FLJ30173; FLJ40909; DKFZp686G1648; DKFZp686L2097
Cat.#:PFKL-1657HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFKL, GST-tagged
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Cat.#:PFKL-1658HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PFKL protein, GST-tagged
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Cat.#:PFKL-12664MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PFKL Protein
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Cat.#:PFKL-4394RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PFKL Protein
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Cat.#:Pfkl-8012RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pfkl protein, His & T7-tagged
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Cat.#:PFKL-3272HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PFKL 293 Cell Lysate
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Cat.#:PFKL-3273HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PFKL 293 Cell Lysate
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Involved Pathway

PFKL involved in several pathways and played different roles in them. We selected most pathways PFKL participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFKL were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
PFKP; ALDOCB; PGM1; GM5506; HK1; LDHC; PDHA2; PKMA; FBP2; PDHA1A
Pentose phosphate pathway
DERA; TALDO1; PGD; RPIA; PRPS1L1; PFKMA; PRPS2; H6PD; ALDOA; GPIB
Fructose and mannose metabolism
ALDOCB; GMDS; PMM1; ENOSF1; PFKFB4L; AKR1B10; HK3; FBP1; TPI1; ALDOA
Galactose metabolism
PGM1; GLA; B4GALT2; HK1; UGP2B; PFKP; GALK1; LCT; GANC; G6PCA.2
Metabolic pathways
ACSM5; PTGS2A; NME2B.2; PIGH; MT-ATP6; ATP6V1C1A; GALCA; PGLS; DGUOK; UPRT
Carbon metabolism
SHMT1; GOT1; DLDH; ESD; GPIA; ALDOB; ACSS2; PGAM1B; PRPS1; GOT2B
Biosynthesis of amino acids
CBSA; BCAT1; PC; PFKP; GLUL; ALDOA; TPI1B; CBSB; GLULA; ACO1
RNA degradation
PARN; NUDT16; EXOSC3; PABPC1; LSM3; DCPS; EDC4; PAN3; EXOSC7; LSM6
HIF- signaling pathway
PRKCG; TF; IFNGR2; NOS3; TIMP1; RPS6KB2; PIK3R3; VEGFA; CAMK2D; TEK
AMPK signaling pathway
G6PC2; MTOR; EEF2K; PIK3CB; PIK3R5; SREBF1; STRADA; PCK1; SCD5; IRS2
Glucagon signaling pathway
PLCB2; PFKFB1; PRKAA2; GYS1; PHKG2; PLCB4; CALM2; PLCB1; PDHA2; PHKB
Central carbon metabolism in cancer
PIK3CD; SLC7A5; MAPK1; G6PDX; PDHB; SLC2A2; PIK3R2; AKT2; FGFR3; PDHA1

Protein Function

PFKL has several biochemical functions, for example, 6-phosphofructokinase activity, contributes_to 6-phosphofructokinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFKL itself. We selected most functions PFKL had, and list some proteins which have the same functions with PFKL. You can find most of the proteins on our site.
Function
Related Protein
Function 6-phosphofructokinase activity
Related Protein PFKMA; PFKMB; PFKP; PFKM; PFKL; PFKLB
Function contributes_to 6-phosphofructokinase activity
Related Protein PFKL
Function ATP binding
Related Protein MAP3K12; PIK3CG; TRIB3; PSMC1A; SPATA5; SMYHC1; NLRP4B; FGFR1; ENTPD1; NLRX1
Function fructose binding
Related Protein ALDOB; PFKM; ALDOA; PFKL
Function fructose-6-phosphate binding
Related Protein PFKL; GCKR; PFKFB1
Function identical protein binding
Related Protein REG3B; TLE1; KCNH2; CXADR; TRIM39; ATXN10; BRI3; ZDHHC17; C; BIN1
Function kinase binding
Related Protein TENC1; PER3; TAX1BP1; LDHA; MOBKL1A; JAKMIP2; CHP; ATF5; SRC; BTG1
Function metal ion binding
Related Protein EME1; HIVEP2A; RNF11B; ZNF829; ZFAND5B; ZNF511; CALUB; PRKCHB; ZNF460; KDM6B
Function protein binding
Related Protein TRIM42; HIST1H3G; TYRP1; SCN11A; SMO; TSNAX; SLIRP; THG1L; C9orf142; DR1

Interacting Protein

PFKL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFKL here. Most of them are supplied by our site. Hope this information will be useful for your research of PFKL.
PFKM; KRTAP5-9; KRTAP10-7; GTPBP3; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate

PFKL Related Articles

Shin, JH; Krapfenbauer, K; et al. Mass-spectrometrical analysis of proteins encoded on chromosome 21 in human fetal brain. AMINO ACIDS 31:435-447(2006).
Peled-Kamar, M; Degani, H; et al. Altered brain glucose metabolism in transgenic-PFKL mice with elevated L-phosphofructokinase: in vivo NMR studies. BRAIN RESEARCH 810:138-145(1998).