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PFKM

  • Official Full Name

    Fructose-6-Phosphate Kinase

  • Overview

    Phosphofructokinase catalyzes the irreversible conversion of fructose 6 phosphate to fructose 1,6 bisphosphate. Mammalian PFK is a complex isozyme consisting of 3 subunits: muscle (M), liver (L), and platelet (P). Each subunit is encoded by a separate structural locus on chromosomes 1(M), 21(L), and 10(P). PFKL is the major form in liver and kidney while only M type PFK isozyme is expressed in mature muscle; therefore, muscle contains only homotetramers of M subunits. Erythrocytes contain both L and M subunits, and these randomly tetramerize to form M4, L4, and 3 additional hybrid forms of the holoenzyme.
  • Synonyms

    Fructose-6-Phosphate Kinase; 6 Phosphofructokinase Muscle; EC 2.7.1.11; GSD7; MGC8699; PFKA; PFKL; PFKM; PFKP; PFKX; Phosphofructo 1 Kinase Isozyme A; Phosphofructokinase 1; Phosphofructokinase M; Phosphofructokinase muscle; Phosphofructokinase muscle type; Phosphofructokinase polypeptide X; Phosphohexokinase; 6-phosphofructokinase; phosphofructokinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PFKM-8640H Recombinant Human PFKM, His-GST tagged Insect Cell His
Human PFKM-28950TH Recombinant Human PFKM, His-tagged E.coli His 780 amino acids
Human PFKM-28952TH Recombinant Human PFKM, His-tagged E.coli His
Human PFKM-2362H Recombinant Human Phosphofructokinase, Muscle, His-tagged E.coli His
Human PFKM-3271HCL Recombinant Human PFKM 293 Cell Lysate HEK293 N/A
Human PFKM-2582H Recombinant Human PFKM Protein, His-tagged E.coli N-His Thr2-His390
Human PFKM-473HFL Recombinant Full Length Human PFKM Protein, C-Flag-tagged Mammalian cells Flag
Human PFKM-2855H Recombinant Human PFKM Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PFKM-1653H Recombinant Human PFKM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PFKM-4870H Recombinant Human PFKM Protein (Thr2-Val780), C-His tagged Mammalian cells C-His Thr2-Val780
Human PFKM-1653H-B Recombinant Human PFKM Protein Pre-coupled Magnetic Beads HEK293
Mouse PFKM-12665M Recombinant Mouse PFKM Protein Mammalian Cell His
Mouse PFKM-6654M Recombinant Mouse PFKM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pfkm-4810M Recombinant Mouse Pfkm Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PFKM-6654M-B Recombinant Mouse PFKM Protein Pre-coupled Magnetic Beads HEK293
Rat PFKM-4395R Recombinant Rat PFKM Protein Mammalian Cell His
Rat Pfkm-8011R Recombinant Rat Pfkm protein, His & T7-tagged E.coli His/T7 Thr2~His390 (Accession # P47858)
Rat PFKM-4055R-B Recombinant Rat PFKM Protein Pre-coupled Magnetic Beads HEK293
Rat PFKM-4055R Recombinant Rat PFKM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken PFKM-5796C Recombinant Chicken PFKM Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PFKM involved in several pathways and played different roles in them. We selected most pathways PFKM participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFKM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisAKR1A1B;PKLR;MINPP1;LDHC;AKR1A1;GALM;ADH1B;ADH7;ADH4
Pentose phosphate pathwayH6PD;deoC;PGM2;FBP1B;PRPS1A;TALDO1;PRPS1L1;ALDOC;FBP2
Fructose and mannose metabolismKHK;PFKM;ALDOC;FBP1;PFKFB2;ALDOB;ENOSF1;PFKP;GMPPAA
Galactose metabolismSI;G6PCA.1;UGP2;PFKM;GANC;aLA;PFKP;GLB1;HK2
Metabolic pathwaysSDSL;PYGL;LIPT2;UROC1;ADKA;COASY;IDH2;PYGMA;PLD2
Carbon metabolismACAT1;HADHAB;MDH1AA;DLDH;PSPH;ENO1B;PCCB;ADPGK;GPT
Biosynthesis of amino acidsPRPS2;PRPS1B;CS;ALDOCA;NAGS;PFKMB;pykF;PCXB;TKTB
RNA degradationPABPC5;LSM3;SKIV2L;RQCD1;PABPC1L;TOB1B;DDX6;CNOT7;HSPA9
AMPK signaling pathwayLEPR;PRKAG2;RAB8A;STK11;TSC2;FOXO3;INSR;CAB39L;CAMKK1
Central carbon metabolism in cancerFGFR2;PGAM2;PIK3R5;IDH1;GLS;PKM;PIK3CA;TP53;MAPK3

PFKM has several biochemical functions, for example, 6-phosphofructokinase activity, ATP binding, fructose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFKM itself. We selected most functions PFKM had, and list some proteins which have the same functions with PFKM. You can find most of the proteins on our site.

Function Related Protein
6-phosphofructokinase activityPFKM;PFKMB;PFKL;PFKP;PFKMA;PFKLB
ATP bindingNLRP11;NPR2;NPR1;MELK;PRKACG;PRKACAB;PIP5KL1;DDX39AA;HSPA9
fructose bindingPFKM;PFKL;ALDOA;ALDOB
identical protein bindingERBB2;PARK7;CHAF1A;APPL1;SMAD3;TPD52L1;L3MBTL1;PIP4K2C;STAT6
kinase bindingLDHA;EMP2;TRADD;C2orf44;PRPSAP1;PFKM;MOB4;PRKCD;PFKL
metal ion bindingPPM1BA;ANKMY1;USP19;MICALL2A;OGDH;SNAI1;NT5C2B;SDHB;ANKIB1
protein C-terminus bindingPIAS3;SCLT1;PLEKHB1;VGLL1;NCL;ZBTB16;FOXN3;VAMP2;PDZD11
protein bindingSLC22A2;CAMK1;SDHA;TCEB3B;STRN;LSM7;CCDC67;UTP23;HNRNPUL1
protein homodimerization activityUGT1A1;IZUMO3;GSTA4;GNB2L1;PVRL1B;BCL2L1;MYH7;MVD;GDF7

PFKM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFKM here. Most of them are supplied by our site. Hope this information will be useful for your research of PFKM.

PFKL; SIAH1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; MCC; NDUFB2; Hoxa1; MAPK3; PDGFRL; SFRP4

  • Q&As
  • Reviews

Q&As (5)

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Are there any known drug interactions involving PFKM-related therapies? 06/27/2019

Drug interactions involving PFKM-related therapies have not been extensively studied, but caution should be exercised in combination with other medications.

Can PFKM mutations be inherited? 11/29/2018

Yes, PFKM deficiency is an autosomal recessive disorder, meaning it can be passed on from both parents.

How can PFKM protein be targeted for therapeutic interventions? 09/17/2018

Targeting PFKM with small molecule inhibitors or gene therapies is being explored as potential treatment strategies.

Can PFKM levels be used as a biomarker for certain diseases? 01/11/2018

PFKM levels have been studied as potential biomarkers for cancer and metabolic disorders, but more research is needed for clinical application.

Are there any known associations between PFKM and cardiovascular diseases? 01/17/2016

Research suggests that PFKM may play a role in cardiac energy metabolism and could be implicated in cardiovascular diseases.

Customer Reviews (3)

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Reviews
09/25/2022

    As a researcher, utilizing PFKM protein in trials offers numerous advantages that contribute to the successful completion of experiments and the acquisition of valuable data.

    03/14/2022

      manufacturers offer customization options, such as alternative conjugation methods or tailored formulations, allowing researchers to optimize PFKM protein to their specific experimental needs.

      06/04/2021

        This ensures the consistency and reproducibility of experimental results, promoting confidence in the obtained data.

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