pfn2
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  • Official Full Name
  • profilin 2
  • Background
  • The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.
  • Synonyms
  • PFN2; profilin 2; profilin-2; D3S1319E; PFL; PFN 2; Profilin II; Profilin2; ProfilinII; OTTHUMP00000216204; OTTHUMP00000216339; OTTHUMP00000216340; OTTHUMP00000216346
Cat.#:PFN2-140HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFN2 protein, T7-tagged
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Cat.#:PFN2-2361HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Profilin 2, His-tagged
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Cat.#:PFN2-30344THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFN2, His-tagged
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Cat.#:PFN2-332HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFN2, His tagged
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Cat.#:PFN2-644HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFN2 Protein
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Cat.#:PFN2-12668MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PFN2 Protein
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Cat.#:PFN2-4397RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PFN2 Protein
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Cat.#:PFN2-784CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PFN2 Protein, His-tagged
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Cat.#:PFN2-3592CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PFN2
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Cat.#:PFN2-11482ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PFN2
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Cat.#:PFN2-3267HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PFN2 293 Cell Lysate
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Cat.#:PFN2-3268HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PFN2 293 Cell Lysate
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Involved Pathway

PFN2 involved in several pathways and played different roles in them. We selected most pathways PFN2 participated on our site, such as Rap signaling pathway, Regulation of actin cytoskeleton, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
INS1; FGF11; INS; PLCB4; AKT1; SIPA1L2; FGF2; CALM1; NGFR; INSR
Regulation of actin cytoskeleton
MYH10; PAK2; MYL1; FGF11; VAV2; VCLA; TMSB4X; PIK3R1; BAIAP2A; ROCK2A
Shigellosis
WASF1; U2AF1; MAPK12; ACTG1; IKBKG; HCLS1; NFKB1; ITGA5; ELMO2; FBXW11
Salmonella infection
NOS2A; WASF1; PFN2L; PFN3; MAPK14A; CCL4L2; NOS2; ROCK2; TLR4; KLC1

Protein Function

PFN2 has several biochemical functions, for example, actin monomer binding, adenyl-nucleotide exchange factor activity, phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFN2 itself. We selected most functions PFN2 had, and list some proteins which have the same functions with PFN2. You can find most of the proteins on our site.
Function
Related Protein
Function actin monomer binding
Related Protein MYL2; TMSB10; NOS3; ABL2; CORO1A; TMSB4X; MYL3; PFN2; COBLL1; TWF2
Function adenyl-nucleotide exchange factor activity
Related Protein GRPEL1; PFN2; GRPEL2; SIL1; HSPBP1; PFN1
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein ALOX15; FRMPD4; KCNJ1; PHLDA3; Apba1; SYT1; TTPA; SCIN; EXOC1; LDLRAP1
Function protein binding
Related Protein BAP1; C7orf50; STRA13; MLKL; BRE; DHX58; RNF213; HILPDA; ESRP1; PCBD2

Interacting Protein

PFN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFN2.
Wasl; HTT; GOLGB1; EPB41; HLA-B; VHL; WASF1; PRKAB1; TRAF6; SGTA; NDUFB8; DLST; RPS10; RAP1GAP

PFN2 Related Articles

Mas, S; Garrido-Arandia, M; et al. Characterization of Profilin and Polcalcin Panallergens From Ash Pollen. JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY 24:257-266(2014).
Ribeiro, H; Morales, S; et al. Analysis of the pollen allergen content of twelve olive cultivars grown in Portugal. AEROBIOLOGIA 29:513-521(2013).