PFN2
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Official Full Name
profilin 2
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Overview
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. -
Synonyms
PFN2; profilin 2; profilin-2; D3S1319E; PFL; PFN 2; Profilin II; Profilin2; ProfilinII; OTTHUMP00000216204; OTTHUMP00000216339; OTTHUMP00000216340; OTTHUMP00000216346;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- MBP
- C
- SUMO
- T7
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- PFN2 Related Articles
PFN2 involved in several pathways and played different roles in them. We selected most pathways PFN2 participated on our site, such as Rap signaling pathway, Regulation of actin cytoskeleton, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | RAP1GAP;GNAS;RALGDS;Kitl;ITGA2B;Adcy4;PIK3CG;AKT2;PRKD1 |
| Regulation of actin cytoskeleton | FGF13B;PPP1CAB;ACTB1;VAV1;VCLA;FGF9;PIP4K2A;MYLPF;INS1 |
| Shigellosis | ABL1;U2AF1L4;RHOG;CD44;IKBKG;CDC42;PFN4;NFKB1;NFKBIB |
| Salmonella infection | CXCL8B.3;ACTG1;IFNG;IFNGR1;PYCARD;MAPK3;NOS2;PFN4;WASF1 |
PFN2 has several biochemical functions, for example, actin monomer binding, adenyl-nucleotide exchange factor activity, phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFN2 itself. We selected most functions PFN2 had, and list some proteins which have the same functions with PFN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin monomer binding | CORO1A;TMSB;COBL;LIMA1;COBLL1;TMSB4X;MYL2;MTSS1;MKL1B |
| adenyl-nucleotide exchange factor activity | HSPBP1;SIL1;GRPEL1;PFN1;GRPEL2;PFN2 |
| phosphatidylinositol-4,5-bisphosphate binding | CCDC167;ALOX15;ACTN2;KCNJ1;FCHO2;TTPA;RAB35;COMMD1;RAG2 |
| protein binding | CBX1;RSL24D1;ALOX5;ZNF230;ROR2;APOBEC2A;SH2D1A;VSNL1;TMEM30B |
PFN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFN2.
Wasl; HTT; GOLGB1; EPB41; HLA-B; VHL; WASF1; PRKAB1; TRAF6; SGTA; NDUFB8; DLST; RPS10; RAP1GAP
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