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PGAM2

  • Official Full Name

    phosphoglycerate mutase 2 (muscle)

  • Overview

    Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.
  • Synonyms

    PGAM2; phosphoglycerate mutase 2 (muscle); phosphoglycerate mutase 2; PGAM M; BPG dependent PGAM 2; BPG-dependent PGAM 2; GSD10; MGC88743; Muscle specific phosphoglycerate mutase; Muscle-specific phosphoglycerate mutase; OTTHUMP00000207787; PGAM-M; PGAM2_HUMAN; PGAMM; Phosphoglycerate mutase isozyme M;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PGAM2-15H Active Recombinant Human PGAM2 protein, His-tagged (Bioactivity Validated) E.coli His
Human PGAM2-1932H Recombinant Human Phosphoglycerate Mutase 2 (muscle), His-tagged His
Human PGAM2-1163H Recombinant Human PGAM2 Mammalian Cell His
Human PGAM2-1662H Recombinant Human PGAM2, GST-tagged E.coli GST 1-253aa
Human PGAM2-3263HCL Recombinant Human PGAM2 293 Cell Lysate HEK293 N/A
Human PGAM2-1657H-B Recombinant Human PGAM2 Protein Pre-coupled Magnetic Beads HEK293
Human PGAM2-1997HFL Recombinant Full Length Human PGAM2 Protein, C-Flag-tagged Mammalian cells Flag
Human PGAM2-1657H Recombinant Human PGAM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PGAM2-12674M Recombinant Mouse PGAM2 Protein Mammalian Cell His
Mouse Pgam2-1744M Recombinant Mouse Pgam2 protein, His & T7-tagged E.coli His/T7 Met1~Lys253 (Accession # O70250)
Mouse PGAM2-6658M Recombinant Mouse PGAM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PGAM2-6658M-B Recombinant Mouse PGAM2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Pgam2-4816M Recombinant Mouse Pgam2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PGAM2-4400R Recombinant Rat PGAM2 Protein Mammalian Cell His
Rat PGAM2-4060R-B Recombinant Rat PGAM2 Protein Pre-coupled Magnetic Beads HEK293
Rat PGAM2-4060R Recombinant Rat PGAM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PGAM2-11256Z Recombinant Zebrafish PGAM2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PGAM2 involved in several pathways and played different roles in them. We selected most pathways PGAM2 participated on our site, such as Glycolysis / Gluconeogenesis, Glycine, serine and threonine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisGPI1;ENO1A;ENO3;ALDOCB;PGAM1;FBP1A;MINPP1B;ADH2-2;LDHA
Glycine, serine and threonine metabolismALAS1;DAO.1;SDSL;PGAM1A;PGAM1;AGXT;ALAS2;GRHPRA;GNMT
Metabolic pathwaysADH7;STT3B;B3GALT6;PIP5KL1;MGAT3;ENO2;PAPSS1;PRPS2;ACADS
Carbon metabolismALDOAA;GM5506;PGAM1A;GLDC;GPR19;GLUD1A;ALDOCB;IDH3B;ACAT1
Biosynthesis of amino acidsIDH3A;TAT;CS;AADAT;PKMB;GLULC;MAT2AB;ALDOA;IDH3B
Central carbon metabolism in cancerERBB2;MAP2K1;PGAM1;PTEN;MTOR;MET;C12orf5;PFKM;NRAS

PGAM2 has several biochemical functions, for example, 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity, bisphosphoglycerate 2-phosphatase activity, bisphosphoglycerate mutase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PGAM2 itself. We selected most functions PGAM2 had, and list some proteins which have the same functions with PGAM2. You can find most of the proteins on our site.

Function Related Protein
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activityPGAM1B;PGAM2;PGAM1A
bisphosphoglycerate 2-phosphatase activityBPGM;PGAM2;C12orf5;TIGARB;TIGARA;PGAM1
bisphosphoglycerate mutase activityPGAM2;BPGM;PGAM1
cofactor bindingME3;TYMS;C3;ACLY;ACLYA;ASNS;PGAM2;DDO;WWOX
phosphoglycerate mutase activityPGAM1;PGAM1A;PGAM1B;BPGM;PGAM2

PGAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PGAM2.

USP15; NS; GABARAPL1; SH3GLB1

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