pgam2
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  • Official Full Name
  • phosphoglycerate mutase 2 (muscle)
  • Background
  • Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.
  • Synonyms
  • PGAM2; phosphoglycerate mutase 2 (muscle); phosphoglycerate mutase 2; PGAM M; BPG dependent PGAM 2; BPG-dependent PGAM 2; GSD10; MGC88743; Muscle specific phosphoglycerate mutase; Muscle-specific phosphoglycerate mutase; OTTHUMP00000207787; PGAM-M; PGAM2_HUMAN; PGAMM; Phosphoglycerate mutase isozyme M
Cat.#:PGAM2-1932HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Phosphoglycerate Mutase 2 (muscle), His-tagged
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Cat.#:PGAM2-1163HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PGAM2
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Cat.#:PGAM2-15HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PGAM2 protein, His-tagged (Bioactivity Validated)
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Cat.#:PGAM2-1662HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PGAM2, GST-tagged
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Cat.#:PGAM2-12674MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PGAM2 Protein
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Cat.#:Pgam2-1744MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pgam2 protein, His & T7-tagged
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Cat.#:PGAM2-4400RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PGAM2 Protein
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Cat.#:PGAM2-11256ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PGAM2
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Cat.#:PGAM2-3263HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PGAM2 293 Cell Lysate
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Involved Pathway

PGAM2 involved in several pathways and played different roles in them. We selected most pathways PGAM2 participated on our site, such as Glycolysis / Gluconeogenesis, Glycine, serine and threonine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGAM2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
PDHA1A; HK1; BPGM; TPI1; ADPGK; MINPP1B; PGAM1B; HK3; PKM2; PGAM1A
Glycine, serine and threonine metabolism
CBSA; THA1; ALDH7A1; BHMT; PHGDH; ALAS2; DAO.2; AOC3; AGXTB; PSAT1
Metabolic pathways
DPM3; GALNT4; IDH3B; PTGS2B; PPAT; CYP2R1; ALPI.1; H2-KE6; NANP; CECR1
Carbon metabolism
ME1; ESD; ECHS1; OGDHA; ALDOB; ACAT2; ACSS2; HK1; pykF; SUCLA2
Biosynthesis of amino acids
ALDOCB; ACY1; ALDOC; SHMT2; GPT; IDH2; MAT1A; ALDH7A1; PFKP; SHMT1
Glucagon signaling pathway
SIK2; GYS1; PHKG2; PLCB2; PHKA1; PPP3R2; GNAQ; PPARA; PRKACB; CPT1C
Central carbon metabolism in cancer
PDGFRB; G6PDX; ERBB2; AKT2; RAF1; PIK3CD; PDGFRA; SLC1A5; SIRT3; PIK3CA

Protein Function

PGAM2 has several biochemical functions, for example, 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity, bisphosphoglycerate 2-phosphatase activity, bisphosphoglycerate mutase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PGAM2 itself. We selected most functions PGAM2 had, and list some proteins which have the same functions with PGAM2. You can find most of the proteins on our site.
Function
Related Protein
Function 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
Related Protein PGAM1A; PGAM2; PGAM1B
Function bisphosphoglycerate 2-phosphatase activity
Related Protein PGAM1; C12orf5; BPGM; PGAM2; TIGARB; TIGARA
Function bisphosphoglycerate mutase activity
Related Protein BPGM; PGAM2; PGAM1
Function cofactor binding
Related Protein PAH; BIRC5; WWOX; ACLY; TYMS; HACL1; HIF1AN; TKT; ASNS; DDO
Function phosphoglycerate mutase activity
Related Protein BPGM; PGAM1B; PGAM1A; PGAM1; PGAM2

Interacting Protein

PGAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PGAM2.
USP15; NS; GABARAPL1; SH3GLB1