pgam2
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  • Official Full Name
  • phosphoglycerate mutase 2 (muscle)
  • Background
  • Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.
  • Synonyms
  • PGAM2; phosphoglycerate mutase 2 (muscle); phosphoglycerate mutase 2; PGAM M; BPG dependent PGAM 2; BPG-dependent PGAM 2; GSD10; MGC88743; Muscle specific phosphoglycerate mutase; Muscle-specific phosphoglycerate mutase; OTTHUMP00000207787; PGAM-M; PGAM2_HUMAN; PGAMM; Phosphoglycerate mutase isozyme M
Cat.#:PGAM2-1932HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Phosphoglycerate Mutase 2 (muscle), His-tagged
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Cat.#:PGAM2-1163HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PGAM2
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Cat.#:PGAM2-15HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PGAM2 protein, His-tagged (Bioactivity Validated)
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Cat.#:PGAM2-1662HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PGAM2, GST-tagged
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Cat.#:PGAM2-12674MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PGAM2 Protein
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Cat.#:Pgam2-1744MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pgam2 protein, His & T7-tagged
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Cat.#:PGAM2-4400RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PGAM2 Protein
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Cat.#:PGAM2-11256ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PGAM2
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Cat.#:PGAM2-3263HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PGAM2 293 Cell Lysate
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Involved Pathway

PGAM2 involved in several pathways and played different roles in them. We selected most pathways PGAM2 participated on our site, such as Glycolysis / Gluconeogenesis, Glycine, serine and threonine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGAM2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
PGM1; ACSS1; ALDH7A1; ENO3; ADH2-1; DLDH; GPIB; ENO1B; PKMA; AKR1A1
Glycine, serine and threonine metabolism
CBSA; DAO; BHMT; AMT; GLYCTK; DLDH; GCSHA; DAO.3; CHDH; AGXTA
Metabolic pathways
TYRP1B; CTH; NAT2; LIPG; PLA2G4D; NDUFB8; PNP6; GNE; ATP6V0CA; QARS
Carbon metabolism
PCXB; PFKL; SDHA; SHMT1; CAT; ALDOCA; FBP1B; ME1; TPI1B; PGK1
Biosynthesis of amino acids
IDH2; PFKP; PRPS1; CBS; ALDOB; ALDH7A1; PC; PGAM2; ALDOA; GM5506
Glucagon signaling pathway
PRKACG; LDHAL6A; PYGL; PKM2; AKT2; CAMK2B; EP300; PPARA; PCK1; PDE3B
Central carbon metabolism in cancer
PIK3R3; PDGFRA; PDHB; RET; SIRT3; SIRT6; SLC16A3; AKT2; SCO2; HKDC1

Protein Function

PGAM2 has several biochemical functions, for example, 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity, bisphosphoglycerate 2-phosphatase activity, bisphosphoglycerate mutase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PGAM2 itself. We selected most functions PGAM2 had, and list some proteins which have the same functions with PGAM2. You can find most of the proteins on our site.
Function
Related Protein
Function 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
Related Protein PGAM2; PGAM1B; PGAM1A
Function bisphosphoglycerate 2-phosphatase activity
Related Protein PGAM1; TIGARB; PGAM2; TIGARA; BPGM; C12orf5
Function bisphosphoglycerate mutase activity
Related Protein PGAM1; BPGM; PGAM2
Function cofactor binding
Related Protein PHYH; HIF1AN; DAO; ASNS; DDO; PAH; PGAM2; WWOX; C3; HACL1
Function phosphoglycerate mutase activity
Related Protein PGAM1A; PGAM1B; PGAM1; PGAM2; BPGM

Interacting Protein

PGAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PGAM2.
USP15; NS; GABARAPL1; SH3GLB1