phc1
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  • Official Full Name
  • polyhomeotic homolog 1 (Drosophila)
  • Background
  • This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene;product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1.;The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named;homology domains I and II. These domains are involved in protein-protein interactions and may mediate;heterodimerization of the protein encoded by this gene and the EDR2 protein.
  • Synonyms
  • PHC1; polyhomeotic homolog 1 (Drosophila); early development regulator 1 (homolog of polyhomeotic 1) , EDR1, polyhomeotic like 1 (Drosophila); polyhomeotic-like protein 1; HPH1; RAE28; Early development regulatory protein 1; EDR1 PH1; mPH1; PH1; OTTHUMP00000238481; OTTHUMP00000238482; OTTHUMP00000238483; polyhomeotic-like 1; early development regulator 1 (homolog of polyhomeotic 1); EDR1
Cat.#:PHC1-1675HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PHC1, GST-tagged
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Cat.#:PHC1-3402RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PHC1 Protein, His-tagged
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Cat.#:PHC1-1396CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PHC1
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Cat.#:PHC1-11728ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PHC1
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Cat.#:PHC1-3239HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PHC1 293 Cell Lysate
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Involved Pathway

PHC1 involved in several pathways and played different roles in them. We selected most pathways PHC1 participated on our site, such as Cellular Senescence, Cellular responses to stress, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHC1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cellular Senescence
RNF2; PHC3; TERF1; TERF2IP; HIST1H1C; RAD50; EP400; HIRA; POT1; UBN1
Cellular responses to stress
HIST1H1B; HIST1H1A; HIST4H4; WDR45; KDM6B; WIPI1; ST13; NUPL2; AMBRA1A; HIST3H2BB
Metabolism of proteins
ADAMTSL3; MPDU1B; RNF2; ST8SIA3; SENP5; SLC25A12; ASNA1; B3GALTL; ATP6AP2; ARSD
Oxidative Stress Induced Senescence
MINK1; BMI1B; RING1; CBX6A; BMI1A; SUZ12A; CBX8B; SUZ12B; CBX6; RNF2
Post-translational protein modification
CNIH3; TRAPPC2; PIGK; OTOP2; ADAMTS18; MUC12; SSPO; UBA2; ADAMTSL3; MUC20
SUMO E3 ligases SUMOylate target proteins
PHC1; PHC2; EID3; NSMCE1; SMC6; CBX4; RING1; CBX8; PHC3; SMC5
SUMOylation
NSMCE4A; CBX8; SAE1; NSMCE2; EID3; UBA2; SMC5; SENP5; NSMCE1; PHC3
SUMOylation of DNA damage response and repair proteins
NSMCE1; SMC6; PHC2; CBX8; PHC3; NSMCE2; RNF2; PHC1; SMC5; SCMH1

Protein Function

PHC1 has several biochemical functions, for example, DNA binding, chromatin binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHC1 itself. We selected most functions PHC1 had, and list some proteins which have the same functions with PHC1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein TSHZ1; ZNF358; ILF2; RNF141; RBM6; ZNF398; OLIG2; HER4.3; IGHMBP2; RAD51L1
Function chromatin binding
Related Protein CITED1; L3MBTL1; EBF2; ASCL1; HOXD13; EOMES; GPR30; RAG2; LDB2A; GATA4
Function zinc ion binding
Related Protein CYHR1; ADAM1B; MSRB1; CSRP3; RNF220A; RNF183; MEP1A.2; SF1; RNF169; LHX1

Interacting Protein

PHC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHC1.
CBX4; BMI1; PCGF2; CBX8; q81y32_bacan; HSPA8; PPP1CA; UBE2I; y2173_bacan; aadK; PHC2; SFMBT1; CBX4; Bmi1; Cbx2