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PHF1

  • Official Full Name

    PHD finger protein 1

  • Overview

    This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PHF1; PHD finger protein 1; MTF2L2; hPCl1; polycomb-like protein 1; PCL1; PHF2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PHF1-30328TH Recombinant Human PHF1 Wheat Germ N/A 99 amino acids
Human PHF1-1679H Recombinant Human PHF1, His-tagged E.coli His 1-351aa
Human PHF1-1344HCL Recombinant Human PHF1 cell lysate N/A
Mouse PHF1-12714M Recombinant Mouse PHF1 Protein Mammalian Cell His
Mouse PHF1-6682M-B Recombinant Mouse PHF1 Protein Pre-coupled Magnetic Beads HEK293
Mouse PHF1-6682M Recombinant Mouse PHF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PHF1-3403R Recombinant Rhesus monkey PHF1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PHF1-3221R Recombinant Rhesus Macaque PHF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PHF1-3221R-B Recombinant Rhesus Macaque PHF1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PHF1 Related Articles

PHF1 involved in several pathways and played different roles in them. We selected most pathways PHF1 participated on our site, such as Epigenetic regulation of gene expression, Gene Expression, PRC2 methylates histones and DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Epigenetic regulation of gene expressionH3F3B.1;TET1;SUZ12A;DNMT3B;SMARCA5;AEBP2;SIN3B;DNMT3A;RBB4L
Gene ExpressionNFIC;ZNF143A;TRIM28;TET3;ZNF486;HNRNPA0;SNAPC3;HNRNPUL1;ZNF792
PRC2 methylates histones and DNAPHF19;JARID2B;MTF2;JARID2;AEBP2;PHF1

PHF1 has several biochemical functions, for example, methylated histone binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF1 itself. We selected most functions PHF1 had, and list some proteins which have the same functions with PHF1. You can find most of the proteins on our site.

Function Related Protein
methylated histone bindingCHD8;LOXL2;RRP8;RBBP5;FAM156A;UHRF1;L3MBTL2;JHDM1D;ING4
protein bindingTSPO;WBP1L;COL1A1;ASB3;IRF2BP1;GOLGA2;EPRS;SPRY4;FAN1
transcription factor activity, sequence-specific DNA bindingPOU6F1;CREM;ZFP131;TCF7L1B;ARNT2;GTF2I;FOXS1;GATA1A;FOXA3
zinc ion bindingSHANK3;LHX4;DHX58;DNLZ;Car4;APOBEC2A;ZDHHC5A;ABLIM2;NR6A1B

PHF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF1.

TFCP2; RBPMS; TRIM23; VAC14; CALCOCO2; NAB2

Ittner, A; Bertz, J; et al. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. JOURNAL OF NEUROCHEMISTRY 132:135-145(2015).
Ali, RH; Al-Safi, R; et al. Molecular characterization of a population-based series of endometrial stromal sarcomas in Kuwait. HUMAN PATHOLOGY 45:2453-2462(2014).
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