phf2
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  • Official Full Name
  • PHD finger protein 2
  • Background
  • This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
  • Synonyms
  • PHF2; PHD finger protein 2; lysine-specific demethylase PHF2; CENP 35; centromere protein 35; JHDM1E; jumonji C domain containing histone demethylase 1E; KIAA0662; jumonji C domain-containing histone demethylase 1E; GRC5; CENP-35; MGC176680
Cat.#:PHF2-12724MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PHF2 Protein
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Cat.#:PHF2-7956ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PHF2
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Involved Pathway

PHF2 involved in several pathways and played different roles in them. We selected most pathways PHF2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
KDM1A; MORF4L1; SMARCD3B; SMARCA4; VPS72; BRD1; YEATS4; DR1; ELP4; PADI1
Chromatin organization
YEATS4; MORF4L2; PRMT5; PADI2; MSL2A; EPC1; JHDM1D; JADE1; ING5A; WDR77
HDMs demethylate histones
KDM1A; KDM2AA; JHDM1D; KDM6B; JMJD6; KDM1B; ARID5B; KDM4B; KDM4D; KDM2B

Protein Function

PHF2 has several biochemical functions, for example, 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, C-19 gibberellin 2-beta-dioxygenase activity, C-20 gibberellin 2-beta-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF2 itself. We selected most functions PHF2 had, and list some proteins which have the same functions with PHF2. You can find most of the proteins on our site.
Function
Related Protein
Function 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
Related Protein KDM5D; PHF2; JMJD1C; KDM5BB
Function C-19 gibberellin 2-beta-dioxygenase activity
Related Protein KDM5D; PHF2; KDM5BB; JMJD1C
Function C-20 gibberellin 2-beta-dioxygenase activity
Related Protein JMJD1C; KDM5D; PHF2; KDM5BB
Function DNA-N1-methyladenine dioxygenase activity
Related Protein KDM5D; KDM5BB; ALKBH2; PHF2; ALKBH3; FTO; JMJD1C
Function dioxygenase activity
Related Protein KDM4B; PHYHD1; PHF2; KDM5D; BCO2L; BCO1; KDM5BB; ADOA; OGFOD2; KDM6B
Function histone demethylase activity (H3-K9 specific)
Related Protein KDM4D; KDM4C; KDM7AB; KDM1A; JHDM1D; PHF2; PHF8
Function hypophosphite dioxygenase activity
Related Protein PHF2; KDM5BB; JMJD1C; KDM5D
Function iron ion binding
Related Protein CYP3C1; CYP2X8; CYP27C1; CYP2C70; MSMO1; PLOD1A; TPH1A; PDF; CYP2K22; CYP3A4
Function metal ion binding
Related Protein ZNF773; LIMCH1A; RAD50; ADAT1; WBP4; ZNF362B; CYP2K22; Reln; AOX3; GALNT13
Function methylated histone binding
Related Protein RBBP5; L3MBTL1; CDYL2; CBX4; UHRF1; PHF19; KDM4A; CBX7; SUZ12; GLYR1
Function oxidoreductase activity
Related Protein TXNDC17; VAT1L; CYP2V1; ALOX5B.3; SCD; FRRS1; CYP2J6; DAO.3; CYP26C1; AOC1
Function procollagen-proline dioxygenase activity
Related Protein KDM5D; PHF2; JMJD1C; KDM5BB
Function sulfonate dioxygenase activity
Related Protein JMJD1C; PHF2; KDM5BB; KDM5D
Function contributes_to transcription coactivator activity
Related Protein ARID5B; EP300; CREBBP; PHF2
Function zinc ion binding
Related Protein RNF138; ZDHHC16A; RNF13; KDM5C; ZDHHC19; KAT6B; TTC3; BTR06; ASTL; RNF123

Interacting Protein

PHF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF2.
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PHF2 Related Articles

Shi, G; Wu, M; et al. PHD Finger Protein 2 (PHF2) Represses Ribosomal RNA Gene Transcription by Antagonizing PHF Finger Protein 8 (PHF8) and Recruiting Methyltransferase SUV39H1. JOURNAL OF BIOLOGICAL CHEMISTRY 289:29691-29700(2014).
Lee, KH; Ju, UI; et al. The Histone Demethylase PHF2 Promotes Fat Cell Differentiation as an Epigenetic Activator of Both C/EBP alpha and C/EBP delta. MOLECULES AND CELLS 37:734-741(2014).