phf2
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  • Official Full Name
  • PHD finger protein 2
  • Background
  • This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
  • Synonyms
  • PHF2; PHD finger protein 2; lysine-specific demethylase PHF2; CENP 35; centromere protein 35; JHDM1E; jumonji C domain containing histone demethylase 1E; KIAA0662; jumonji C domain-containing histone demethylase 1E; GRC5; CENP-35; MGC176680
Cat.#:PHF2-12724MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PHF2 Protein
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Cat.#:PHF2-7956ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PHF2
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Involved Pathway

PHF2 involved in several pathways and played different roles in them. We selected most pathways PHF2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
RBB4L; RBBP4; KAT5; C17orf81; USP22; HIST2H3C; NCOA2; KDM5B; BRPF3; RBBP5
Chromatin organization
SMARCC2; EED; SUZ12; GATAD2A; MSL2A; CCDC101; MTA2; ELP4; MBIP; AEBP2
HDMs demethylate histones
KDM4B; KDM3A; KDM5B; KDM2A; KDM5BA; KDM4C; PHF2; JMJD6; PHF8; KDM2B

Protein Function

PHF2 has several biochemical functions, for example, 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, C-19 gibberellin 2-beta-dioxygenase activity, C-20 gibberellin 2-beta-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF2 itself. We selected most functions PHF2 had, and list some proteins which have the same functions with PHF2. You can find most of the proteins on our site.
Function
Related Protein
Function 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
Related Protein PHF2; JMJD1C; KDM5D; KDM5BB
Function C-19 gibberellin 2-beta-dioxygenase activity
Related Protein KDM5D; KDM5BB; JMJD1C; PHF2
Function C-20 gibberellin 2-beta-dioxygenase activity
Related Protein KDM5BB; JMJD1C; PHF2; KDM5D
Function DNA-N1-methyladenine dioxygenase activity
Related Protein JMJD1C; KDM5BB; ALKBH3; ALKBH2; FTO; PHF2; KDM5D
Function dioxygenase activity
Related Protein ALKBH6; ALOX5A; BCO2L; BCO1; ALOX8; ALOX5B.2; KDM5BB; ALOX12E; KDM3A; KDM3B
Function histone demethylase activity (H3-K9 specific)
Related Protein KDM1A; PHF8; KDM4C; KDM7AB; KDM4D; PHF2; JHDM1D
Function hypophosphite dioxygenase activity
Related Protein PHF2; KDM5BB; KDM5D; JMJD1C
Function iron ion binding
Related Protein FAM84B; ALOX12; P4HTM; CYP51A1; FTH1; HBAD; CYP3C1; CYP2B19; CYP11B2; CYP46A1.4
Function metal ion binding
Related Protein TRIM35-31; LIMK1A; ZNF143A; DNLZ; ZBTB4; PRDM12B; DMRTC2; ZFY1; ATP13A5; TYRP1B
Function methylated histone binding
Related Protein MTF2; LOXL2; DPPA3; ING4; PHF13; GLYR1; ZMYND11; RAG2; KAT8; CBX7
Function oxidoreductase activity
Related Protein GPX4A; CYP2J5; CYP2P10; SDR39U1; CYP27C1; ALDH9A1A.2; CYP1C2; PDPR; FRRS1; Scd2
Function procollagen-proline dioxygenase activity
Related Protein KDM5BB; KDM5D; JMJD1C; PHF2
Function sulfonate dioxygenase activity
Related Protein PHF2; KDM5BB; JMJD1C; KDM5D
Function contributes_to transcription coactivator activity
Related Protein ARID5B; CREBBP; PHF2; EP300
Function zinc ion binding
Related Protein CA15C; DZIP3; SLC30A8; MGRN1A; TIMM13; ANKIB1; GRIN2B; ZFAND2A; S100A5; VAT1

Interacting Protein

PHF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF2.
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PHF2 Related Articles

Shi, G; Wu, M; et al. PHD Finger Protein 2 (PHF2) Represses Ribosomal RNA Gene Transcription by Antagonizing PHF Finger Protein 8 (PHF8) and Recruiting Methyltransferase SUV39H1. JOURNAL OF BIOLOGICAL CHEMISTRY 289:29691-29700(2014).
Lee, KH; Ju, UI; et al. The Histone Demethylase PHF2 Promotes Fat Cell Differentiation as an Epigenetic Activator of Both C/EBP alpha and C/EBP delta. MOLECULES AND CELLS 37:734-741(2014).