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PHF2

  • Official Full Name

    PHD finger protein 2

  • Overview

    This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
  • Synonyms

    PHF2; PHD finger protein 2; lysine-specific demethylase PHF2; CENP 35; centromere protein 35; JHDM1E; jumonji C domain containing histone demethylase 1E; KIAA0662; jumonji C domain-containing histone demethylase 1E; GRC5; CENP-35; MGC176680;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse PHF2-12724M Recombinant Mouse PHF2 Protein Mammalian Cell His
Mouse PHF2-6689M Recombinant Mouse PHF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PHF2-6689M-B Recombinant Mouse PHF2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PHF2-7956Z Recombinant Zebrafish PHF2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PHF2 Related Articles

PHF2 involved in several pathways and played different roles in them. We selected most pathways PHF2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesSMARCA4;MORF4L1;PHF2;PADI6;KDM4A;EP400;ING5;MBD3A;JHDM1D
Chromatin organizationSUZ12A;SAP30L;MTA3;KDM5A;ACTL6A;PHF21A;CAPNS2;PADI1;SMYD2
HDMs demethylate histonesPHF8;KDM1A;KDM3B;ARID5B;KDM4B;KDM5D;KDM5B;KDM2AA;KDM1B

PHF2 has several biochemical functions, for example, 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, C-19 gibberellin 2-beta-dioxygenase activity, C-20 gibberellin 2-beta-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF2 itself. We selected most functions PHF2 had, and list some proteins which have the same functions with PHF2. You can find most of the proteins on our site.

Function Related Protein
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activityKDM5D;PHF2;JMJD1C;KDM5BB
C-19 gibberellin 2-beta-dioxygenase activityKDM5D;PHF2;JMJD1C;KDM5BB
C-20 gibberellin 2-beta-dioxygenase activityKDM5D;JMJD1C;KDM5BB;PHF2
DNA-N1-methyladenine dioxygenase activityALKBH2;KDM5D;ALKBH3;FTO;KDM5BB;PHF2;JMJD1C
dioxygenase activityASPHD1;JMJD5;P4HA1B;KDM4D;KDM4C;ASPHD2;TDO2A;ADOA;OGFOD3
histone demethylase activity (H3-K9 specific)KDM4C;KDM1A;KDM4D;PHF8;KDM7AB;PHF2;JHDM1D
hypophosphite dioxygenase activityKDM5D;KDM5BB;PHF2;JMJD1C
iron ion bindingCYP17A2;CYP2AA1;ISCU;OGFOD2;CYP4V2;P4HA2;CYP2C39;CYP2AA9;XDH
metal ion bindingZFP473;ZNF565;PRDM14;RASAL1;LHX1B;GLIS2;HELZ2;SFTPBB;ZFP260
methylated histone bindingMSH6;L3MBTL1;ATRX;SUZ12;CBX8;MSL3;ZMYND11;KAT8;UHRF1
oxidoreductase activityDHRS11B;TXNRD3;ALDH3A2A;SCCPDHA;PDHA1B;CYP2X9;DHRS12;CYP2AA3;CRYM
procollagen-proline dioxygenase activityPHF2;JMJD1C;KDM5BB;KDM5D
sulfonate dioxygenase activityPHF2;JMJD1C;KDM5D;KDM5BB
contributes_to transcription coactivator activityPHF2;EP300;CREBBP;ARID5B
zinc ion bindingGCH1;NR2F6B;APOBEC1;ISL1;KDM5BB;PEG10;NPEPPS;RNF181;NR5A2

PHF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF2.

Ywhae

Shi, G; Wu, M; et al. PHD Finger Protein 2 (PHF2) Represses Ribosomal RNA Gene Transcription by Antagonizing PHF Finger Protein 8 (PHF8) and Recruiting Methyltransferase SUV39H1. JOURNAL OF BIOLOGICAL CHEMISTRY 289:29691-29700(2014).
Lee, KH; Ju, UI; et al. The Histone Demethylase PHF2 Promotes Fat Cell Differentiation as an Epigenetic Activator of Both C/EBP alpha and C/EBP delta. MOLECULES AND CELLS 37:734-741(2014).
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