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PHF21A

  • Official Full Name

    PHD finger protein 21A

  • Overview

    The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
  • Synonyms

    PHF21A; PHD finger protein 21A; BHC80; BM-006; BHC80a; BRAF35/HDAC2 complex (80 kDa); BRAF35-HDAC complex protein BHC80;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PHF21A-3230HCL Recombinant Human PHF21A 293 Cell Lysate HEK293 N/A
Rhesus Macaque PHF21A-3407R Recombinant Rhesus monkey PHF21A Protein, His-tagged Mammalian Cell His
Rhesus Macaque PHF21A-3225R Recombinant Rhesus Macaque PHF21A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PHF21A-3225R-B Recombinant Rhesus Macaque PHF21A Protein Pre-coupled Magnetic Beads HEK293
Chicken PHF21A-4440C Recombinant Chicken PHF21A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PHF21A Related Articles

PHF21A involved in several pathways and played different roles in them. We selected most pathways PHF21A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF21A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesKAT7B;MTA3;ARID4A;JHDM1D;SAP130;ELP3;SAP30L;KDM2A;PRMT6
Chromatin organizationTADA2A;SUZ12B;KDM3B;SMARCA2;MTA1;KDM4A;KDM2AA;MSL1;ACTL6A
Factors involved in megakaryocyte development and platelet productionH3F3B.1;PHF21A;BA1;KIF9;HBD;VPS45;DOCK6;DOCK10;DOCK1
HDACs deacetylate histonesMBD3B;HMG20B;SUDS3;MBD3A;ARID4A;BRMS1;CHD4;KDM1A;GATAD2A
HemostasisHBE1;CFD;IRF2;GATA2;ZFPM2A;OSTN;MMRN1;CEACAM1;RAPGEF3

PHF21A has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF21A itself. We selected most functions PHF21A had, and list some proteins which have the same functions with PHF21A. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II regulatory region sequence-specific DNA bindingGATA1;ZNF583;KLF12;DBP;ZFAT;PRDM12B;HSF2;TBX20;NFKB1
chromatin bindingRELB;ERG;BAHD1;TCF7;TLE1;NR5A1B;ING5;TAF2;SMARCC1
histone bindingUSP49;HIST2H3C1;HIST1H4H;PKN1;SART3;DEK;HIST1H4A;ASF1A;HIST1H4K
protein bindingFAM3C;FAH;LPAR1;ARR3;RIN1;CASKIN1;GLRB;RPTOR;ZBTB43
transcription cofactor activityPHF21A;MED30;MED17;ZNF671;PHF21B;ZFP865;ZFP710;LDB2;MED13
zinc ion bindingZNRF3;RORCA;GATA2A;APOBEC3C;MMP15;SMAD3;BAZ1A;RNF2;APOBEC3F

PHF21A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF21A here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF21A.

NUP62; TRAF1; FHL3; ZYX; KRT40; BANP; HDAC2

Montgomery, ND; Turcott, CM; et al. A 137-kb deletion within the Potocki-Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 161A:198-202(2013).
Kim, HG; Kim, HT; et al. Translocations Disrupting PHF21A in the Potocki-Shaffer-Syndrome Region Are Associated with Intellectual Disability and Craniofacial Anomalies. AMERICAN JOURNAL OF HUMAN GENETICS 91:56-72(2012).
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