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PHF8

  • Official Full Name

    PHD finger protein 8

  • Overview

    The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PHF8; PHD finger protein 8; histone lysine demethylase PHF8; JHDM1F; jumonji C domain containing histone demethylase 1F; KIAA1111; ZNF422; jumonji C domain-containing histone demethylase 1F; MRXSSD; DKFZp686E0868;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Sf9 Insect Cell
  • Flag
  • His
  • His (Fc)
  • Avi
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PHF8-61H Active Recombinant Human PHF8, FLAG-tagged Sf9 Insect Cell Flag
Human PHF8-63H Recombinant Human PHF8, GST-tagged E.coli N/A
Human PHF8-62H Recombinant Human PHF8, GST-tagged E.coli N/A
Human PHF8-0538H Recombinant Human PHF8 Protein (A38-N483), His tagged E.coli His A38-N483
Human PHF8-0537H Recombinant Human PHF8 Protein (A38-N483), Tag Free E.coli No tag A38-N483
Mouse PHF8-12733M Recombinant Mouse PHF8 Protein Mammalian Cell His
Mouse Phf8-751M Recombinant Mouse Phf8 Protein, His-tagged E.coli His Phe195~Lys351
Mouse PHF8-6695M-B Recombinant Mouse PHF8 Protein Pre-coupled Magnetic Beads HEK293
Mouse PHF8-6695M Recombinant Mouse PHF8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PHF8-7972Z Recombinant Zebrafish PHF8 Mammalian Cell His
Kit-1851 PHF8 (KDM7B) Homogeneous Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PHF8 Related Articles

PHF8 involved in several pathways and played different roles in them. We selected most pathways PHF8 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleCDC14B;NCAPG;ANAPC4;STAG1;BARD1;NUPL2;CCND1;TINF2;POT1A
Cell Cycle, MitoticZWINT;AURKB;MCM8;CDK5RAP2;H3F3B.1;KIF18A;ITGB3BP;DNA2;TUBG2
Chromatin modifying enzymesCOPRS;MEAF6;PAX3A;PHF15;BRPF3;TAF6L;PRDM16;TADA2A;CCDC101
Chromatin organizationKDM4A;CSRP2BP;ATXN7L3;ARID5B;BRMS1;PADI2;PHF8;ING5;MORF4L2
Condensation of Prophase ChromosomesSET;SMC4;H3F3D;MCPH1;SMC2;NCAPD3;NCAPG2;SETB;PHF8
HDMs demethylate histonesKDM4D;KDM6AL;ARID5B;JHDM1D;KDM3A;KDM5B;KDM5BB;KDM5BA;PHF8
M PhaseNIPBL;DULLARD;NCAPD3;KIF2B;NSL1;SKA1;SETA;CENPA;LEMD3
Mitotic ProphaseMCPH1;DULLARD;TMEM188;SMC2;NCAPG2;ARPP19;NCAPH2;SET;SETB

PHF8 has several biochemical functions, for example, chromatin binding, histone demethylase activity, histone demethylase activity (H3-K27 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by PHF8 itself. We selected most functions PHF8 had, and list some proteins which have the same functions with PHF8. You can find most of the proteins on our site.

Function Related Protein
chromatin bindingRAG2;GATA4;ASCL1;SMARCD1;ERCC6;ZEB1;DLX2;SHMT2;MSL1A
histone demethylase activityKDM4C;KDM2B;KDM1A;PHF8
histone demethylase activity (H3-K27 specific)KDM6B;PHF8;KDM6BB;JHDM1D;KDM6A;KDM7AB
histone demethylase activity (H3-K36 specific)PHF8;JHDM1D;KDM2B;KDM2A;KDM4A;KDM8;C14orf169;JMJD5
histone demethylase activity (H3-K9 specific)KDM7AB;JHDM1D;PHF2;PHF8;KDM4D;KDM4C;KDM1A
histone demethylase activity (H4-K20 specific)HIST1H4I;HIST1H4H;HIST1H4A;HIST4H4;HIST1H4F;HIST1H4B;HIST1H4C;HIST1H4J;HIST1H4E
iron ion bindingCYP2C19;CYP2K17;CH25HL2;LTF;TET1;TYW1;LEPREL2;CYP2A12;FA2H
methylated histone bindingCBX7;GLYR1;L3MBTL2;ZMYND11;UHRF1;RAG2;MTF2;DPPA3;CCDC101
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsKDM5C;P4HTM;KDM5A;HIF1AN;JHDM1D;EGLN1;ALKBH4;ALKBH8;KDM5B
protein bindingF2RL1;HLA-DRB3;TTC12;FXYD6;CSNK1G2;ZC3H14;NADSYN1;PEX16;DIS3L2
zinc ion bindingITGB1BP2;UMPS;TRIM72;JADE3;ADAMTS20;ATXN7L3;RNF130;ZEB1;HERC2

PHF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF8.

Dlg4; PML-RAR; h3_peptide_2-18; rarb_human_gene; H2AFY; CENPB; EIF6; HIST1H3D; MRPS35; MRPS15; XPC; TRIM26; TRIP12; PLEC; HIST2H2BE; DNTTIP2; RIF1; BRAT1; NOL8; MB21D1

Shi, G; Wu, M; et al. PHD Finger Protein 2 (PHF2) Represses Ribosomal RNA Gene Transcription by Antagonizing PHF Finger Protein 8 (PHF8) and Recruiting Methyltransferase SUV39H1. JOURNAL OF BIOLOGICAL CHEMISTRY 289:29691-29700(2014).
Lubula, MY; Poplawaski, A; et al. Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:1389-1393(2014).
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