pias2
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  • Official Full Name
  • protein inhibitor of activated STAT, 2
  • Background
  • This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.
  • Synonyms
  • PIAS2; protein inhibitor of activated STAT, 2; E3 SUMO-protein ligase PIAS2; miz; PIASX ALPHA; PIASX BETA; zinc finger; MIZ type containing 4; ZMIZ4; DAB2-interacting protein; zinc finger, MIZ-type containing 4; msx-interacting zinc finger protein; protei
Cat.#:PIAS2-1703HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIAS2, GST-tagged
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Cat.#:PIAS2-326HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIAS2 Protein, His-tagged
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Cat.#:PIAS2-4442RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIAS2 Protein
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Cat.#:PIAS2-2335CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIAS2
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Cat.#:PIAS2-3203HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIAS2 293 Cell Lysate
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Cat.#:PIAS2-3204HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIAS2 293 Cell Lysate
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Involved Pathway

PIAS2 involved in several pathways and played different roles in them. We selected most pathways PIAS2 participated on our site, such as Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
CUL3B; FZR1; CUL4B; SOCS3; SOCS1; FANCL; CDC26; CDH1-A; UBE2Z; WWP2
Jak-STAT signaling pathway
IL6R; MCL1A; CCND3; IL7R; LIF; MTOR; CISHB; IL-15RA; OSM; SOCS5B
Pathways in cancer
FLT3LG; SMAD2; STK36; GNG8; HRAS; ERBB2; AGTR1B; GNG13; FZD3; WNT9B
Small cell lung cancer
TRAF5; FHIT; ITGAV; RXRB; PIK3R2; TRAF2; RB1; LAMB2; TRAF4; CASP9

Protein Function

PIAS2 has several biochemical functions, for example, DNA binding, SUMO ligase activity, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS2 itself. We selected most functions PIAS2 had, and list some proteins which have the same functions with PIAS2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein TAF9; NPAS4A; MYNN; HES7; DNMT3A; TBX16; DUX3; NR4A2A; MSGN1; TMEM18
Function SUMO ligase activity
Related Protein PIAS4; PIAS2; PIAS1
Function androgen receptor binding
Related Protein RB1; BRCA1; FHL2; NSD1; PRMT2; TRIM68; KDM1A; EP300; DDX5; RNF4
Function ligase activity
Related Protein RNF19A; ZFP91; DTX4; UBE2G1B; SIAH1A; TRIP12; RAD18; DTX1; ITCHA; TOPORS
Function protein binding
Related Protein CD209; PRAP1; CCDC13; PPP2R4; LBH; FER; CDK5; ST8SIA5; ITGAV; TEKT5
Function transcription coactivator activity
Related Protein APEX1; MYSM1; TAF9; PER2; KAT6A; JMY; PDLIM1; TAF12; RAN; HINFP
Function transcription factor binding
Related Protein IGHMBP2; NKX2; NKX2-1; PIANP; PARK7; MED12; DRAP1; FOSB; CHCHD2; E2F2
Function ubiquitin protein ligase binding
Related Protein MC1R; UBE2G1A; RPA2; VCL; PDE4D; MC4R; UBE2G1; SCAMP3; DLG3; MAP1LC3C
Function zinc ion binding
Related Protein RNF182; JHDM1D; HIF1AN; TRIM101; ZDHHC11; ZNF622; AGBL5; TRIM37; RCHY1; BFAR

Interacting Protein

PIAS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS2.
UBE2I; CCNDBP1; SUMO1; NAV2

PIAS2 Related Articles

Holloway, G; Dang, VT; et al. Rotavirus inhibits IFN-induced STAT nuclear translocation by a mechanism that acts after STAT binding to importin-alpha. JOURNAL OF GENERAL VIROLOGY 95:1723-1733(2014).
Abkhezr, M; Dryer, SE; et al. Angiotensin II and Canonical Transient Receptor Potential-6 Activation Stimulate Release of a Signal Transducer and Activator of Transcription 3-Activating Factor from Mouse Podocytes. MOLECULAR PHARMACOLOGY 86:150-158(2014).