Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

PIAS2

  • Official Full Name

    protein inhibitor of activated STAT, 2

  • Overview

    This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.
  • Synonyms

    PIAS2; protein inhibitor of activated STAT, 2; E3 SUMO-protein ligase PIAS2; miz; PIASX ALPHA; PIASX BETA; zinc finger; MIZ type containing 4; ZMIZ4; DAB2-interacting protein; zinc finger, MIZ-type containing 4; msx-interacting zinc finger protein; protei;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIAS2-1703H Recombinant Human PIAS2, GST-tagged E.coli GST 1-346aa
Human PIAS2-326H Recombinant Human PIAS2 Protein, His-tagged E.coli His
Human PIAS2-3203HCL Recombinant Human PIAS2 293 Cell Lysate HEK293 N/A
Human PIAS2-3204HCL Recombinant Human PIAS2 293 Cell Lysate HEK293 N/A
Rat PIAS2-4442R Recombinant Rat PIAS2 Protein Mammalian Cell His
Rat PIAS2-4102R Recombinant Rat PIAS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PIAS2-4102R-B Recombinant Rat PIAS2 Protein Pre-coupled Magnetic Beads HEK293
Chicken PIAS2-2335C Recombinant Chicken PIAS2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PIAS2 Related Articles
  • PIAS2 Related Research Area
  • PIAS2 Related Signal Pathway

PIAS2 involved in several pathways and played different roles in them. We selected most pathways PIAS2 participated on our site, such as Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisSOCS3B;BIRC7;PML;PIAS4A;CUL5;ITCH;UBE2W;ANAPC4;TRIP12
Jak-STAT signaling pathwayIL28RA;STAT6;Il6ra;LEPA;MTOR;CRLF2;LIF;STAM2;IFNK
Pathways in cancerPRKCA;PTGER2;GNB1;TCF7;TCEB1;FAS;FIGF;PAX8;RALB
Small cell lung cancerNOS2;PIK3R3;IKBKG;BIRC3;ITGA2B;TRAF5;ITGA3;TP53;ITGA6

PIAS2 has several biochemical functions, for example, DNA binding, SUMO ligase activity, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS2 itself. We selected most functions PIAS2 had, and list some proteins which have the same functions with PIAS2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPDS5B;ZNF580;PA2G4;FOXO1B;RXRAA;ZBTB48;ZNF182;ZFP775;EN2
SUMO ligase activityPIAS2;PIAS4;PIAS1
androgen receptor bindingNSD1;PRKCB;CTNNB1;KDM1A;EP300;KAT5;NRIP1;RNF6;Ar
ligase activityPJA2;ZNRF1;IRF2BP1;TRIM56;TRIM68;RBCK1;TTLL11;RNF138;NSMCE2
protein bindingINTS3;XRCC4;DDX39B;ZNF436;PBX1;HIST1H2AI;USP37;WFDC9;TNPO1
transcription coactivator activityGRIP1;NFKB2;YAP1;MTF1;TBPL1;SUB1A;MMS19;IL31RA;CEBPA
transcription factor bindingPPID;SIX2;APBB3;PBX1;ATF7;TMEM173;PSMC5;TNFRSF10A;PIK3R1
ubiquitin protein ligase bindingUSP13;HSPA1A;CDKN1A;SMAD2;CUL3B;CDC34B;TRIB2;XRCC5;RNF40
zinc ion bindingMSRB1;KLF4;ERI2;RNFT2;LMCD1;TRIM8A;SEC24C;RBM14A;APOBEC3C

PIAS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS2.

UBE2I; CCNDBP1; SUMO1; NAV2

Holloway, G; Dang, VT; et al. Rotavirus inhibits IFN-induced STAT nuclear translocation by a mechanism that acts after STAT binding to importin-alpha. JOURNAL OF GENERAL VIROLOGY 95:1723-1733(2014).
Abkhezr, M; Dryer, SE; et al. Angiotensin II and Canonical Transient Receptor Potential-6 Activation Stimulate Release of a Signal Transducer and Activator of Transcription 3-Activating Factor from Mouse Podocytes. MOLECULAR PHARMACOLOGY 86:150-158(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All PIAS2 Products

Required fields are marked with *

My Review for All PIAS2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends