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PIGP

  • Official Full Name

    phosphatidylinositol glycan anchor biosynthesis, class P

  • Overview

    This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms

    PIGP; phosphatidylinositol glycan anchor biosynthesis, class P; Down syndrome critical region gene 5 , DSCR5, phosphatidylinositol glycan, class P; phosphatidylinositol N-acetylglucosaminyltransferase subunit P; DCRC; DSRC; phosphatidylinositol n acetylglucosaminyltranferase subunit; DCRC S; Down syndrome critical region gene 5; Down syndrome critical region protein 5; Down syndrome critical region protein C; DSCR 5; DSCR5; DSCRC; Phosphatidylinositol glycan anchor biosynthesis class P; Phosphatidylinositol glycan biosynthesis class P; Phosphatidylinositol glycan biosynthesis class P protein; Phosphatidylinositol glycan class P; Phosphatidylinositol N acetylglucosaminyltransferase subunit P; PIG-P; OTTHUMP00000109075; OTTHUMP00000109076; OTTHUMP00000109077; OTTHUMP00000109078; OTTHUMP00000109079; phosphatidylinositol glycan, class P; Down syndrome cri; DCRC-S;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIGP-4026H Recombinant Human PIGP Protein, GST-tagged Wheat Germ GST
Human PIGP-3195HCL Recombinant Human PIGP 293 Cell Lysate HEK293 N/A
Human PIGP-3113H Recombinant Human PIGP protein, His-tagged E.coli His 70-134 aa
Homo sapiens (Human) RFL3541HF Recombinant Full Length Human Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit P(Pigp) Protein, His-Tagged E.coli expression system His Full Length (1-158)
Mus musculus (Mouse) RFL8545MF Recombinant Full Length Mouse Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit P(Pigp) Protein, His-Tagged E.coli expression system His Full Length (1-132)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL22343PF Recombinant Full Length Pongo Abelii Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit P(Pigp) Protein, His-Tagged E.coli expression system His Full Length (1-134)
Zebrafish PIGP-10108Z Recombinant Zebrafish PIGP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PIGP Related Articles

PIGP involved in several pathways and played different roles in them. We selected most pathways PIGP participated on our site, such as Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIGP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosylphosphatidylinositol(GPI)-anchor biosynthesisPIGO;PIGS;PIGN;PIGZ;PIGYL;GPLD1;PIGU;DPM2;PIGW
Metabolic pathwaysATP6V0D2;MDH2;CMPK;CKBB;ENO2;PRIM1;FH1;XYLB;TDO2

PIGP has several biochemical functions, for example, contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIGP itself. We selected most functions PIGP had, and list some proteins which have the same functions with PIGP. You can find most of the proteins on our site.

Function Related Protein
contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activityPIGQ;PIGP

PIGP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIGP here. Most of them are supplied by our site. Hope this information will be useful for your research of PIGP.

Hakki, SS; Kayis, SA; et al. Comparison of Mesenchymal Stem Cells Isolated From Pulp and Periodontal Ligament. JOURNAL OF PERIODONTOLOGY 86:283-291(2015).
Kvarnung, M; Nilsson, D; et al. A novel intellectual disability syndrome caused by GPI anchor deficiency due to homozygous mutations in PIGT. JOURNAL OF MEDICAL GENETICS 50:521-528(2013).
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