pigp
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  • Official Full Name
  • phosphatidylinositol glycan anchor biosynthesis, class P
  • Background
  • This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms
  • PIGP; phosphatidylinositol glycan anchor biosynthesis, class P; Down syndrome critical region gene 5 , DSCR5, phosphatidylinositol glycan, class P; phosphatidylinositol N-acetylglucosaminyltransferase subunit P; DCRC; DSRC; phosphatidylinositol n acetylglucosaminyltranferase subunit; DCRC S; Down syndrome critical region gene 5; Down syndrome critical region protein 5; Down syndrome critical region protein C; DSCR 5; DSCR5; DSCRC; Phosphatidylinositol glycan anchor biosynthesis class P; Phosphatidylinositol glycan biosynthesis class P; Phosphatidylinositol glycan biosynthesis class P protein; Phosphatidylinositol glycan class P; Phosphatidylinositol N acetylglucosaminyltransferase subunit P; PIG-P; OTTHUMP00000109075; OTTHUMP00000109076; OTTHUMP00000109077; OTTHUMP00000109078; OTTHUMP00000109079; phosphatidylinositol glycan, class P; Down syndrome cri; DCRC-S
Cat.#:PIGP-4026HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PIGP Protein, GST-tagged
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Cat.#:PIGP-10108ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIGP
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Cat.#:PIGP-3195HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIGP 293 Cell Lysate
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Involved Pathway

PIGP involved in several pathways and played different roles in them. We selected most pathways PIGP participated on our site, such as Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIGP were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
PIGK; GPLD1; PIGM; PIGO; PIGF; GPAA1; PIGU; PIGL; PIGYL; PIGA
Metabolic pathways
GPT2; PLCD3A; ALLC; ST6GALNAC4; ATP6V1G2; CSGALNACT2; PPAP2C; HADHAB; HSD3B2; PCYT2

Protein Function

PIGP has several biochemical functions, for example, contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIGP itself. We selected most functions PIGP had, and list some proteins which have the same functions with PIGP. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity
Related Protein PIGP; PIGQ

PIGP Related Articles

Hakki, SS; Kayis, SA; et al. Comparison of Mesenchymal Stem Cells Isolated From Pulp and Periodontal Ligament. JOURNAL OF PERIODONTOLOGY 86:283-291(2015).
Kvarnung, M; Nilsson, D; et al. A novel intellectual disability syndrome caused by GPI anchor deficiency due to homozygous mutations in PIGT. JOURNAL OF MEDICAL GENETICS 50:521-528(2013).