pik3r3
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
  • Background
  • Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme that in humans is encoded by the PIK3R3 gene.
  • Synonyms
  • PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphatidylinositol 3-kinase regulatory subunit gamma; p55; p55PIK; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; 100% homology to SWISS-PROT Q92569; PI3-kinase regulatory su
Cat.#:PIK3R3-4464RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIK3R3 Protein
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Cat.#:PIK3R3-3436RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R3 Protein, His-tagged
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Cat.#:PIK3R3-3184HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3R3 293 Cell Lysate
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Involved Pathway

PIK3R3 involved in several pathways and played different roles in them. We selected most pathways PIK3R3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
HRASB; KRAS; AKT2; PAK2B; GSK3B; ERBB3B; RPS6KB1; PRKCBB; NRG2; NRG2B
Ras signaling pathway
PLA2G4A; INS; CALM4; GNG8; MAPK8; PLD1; SHC1; GNB1; GNG7; RAB5B
Rap signaling pathway
Kitl; GNAI3; SRC; Fgf15; FGF16; PDGFA; KIT; SIPA1L1; FGF19; PLCG1
cGMP-PKG signaling pathway
MAP2K2; PPP1CB; PPIF; PIK3CD; SLC25A4; PLCB1; CALM1; CREB3L3; PRKG1; PIK3CB
cAMP signaling pathway
PTGER3; FXYD1; CAMK2B; HTR4; DRD1A; HTR1F; GNAI2; PIK3CA; PIK3R1; CAMK4
Chemokine signaling pathway
CCL23; PIK3R3; CDC42; GNGT1; NFKBIB; NCF1; Ccl21a; IL-8; Cxcl15; CCL3L1
HIF- signaling pathway
TFRC; IFNGR2; TF; HK2; MAPK1; ENO1; EIF4E1B; IGF1; LTBR; PIK3R1
FoxO signaling pathway
MAP2K1; CCND2; CCNB2; SMAD4; FOXO3; SGK2B; RAG1; FOXG1A; PTEN; PRKAB1A
Phosphatidylinositol signaling system
CDS1; CALM; PIK3R1; PIK3CG; PIK3R5; PIP4K2C; PIP5K1BB; IMPA2; PLCD1; SYNJ2
Sphingolipid signaling pathway
PIK3CD; LASS1; SPTLC2; NSMAF; NFKB1; SGMS1; PIK3R2; PIK3R1; PLD2; SPHK1
Phospholipase D signaling pathway
SHC3; PLA2G4A; PLA2G4F; PTGFR; F2R; MTOR; SYK; PIK3CG; FCER1A; DNM3
mTOR signaling pathway
RPS6KA6; AKT3A; BRAF; PIK3CB; TSC1A; RRAGCB; RHEB; PIK3CD; EIF4BB; RPS6KB1
PIK-Akt signaling pathway
TRP53; NR4A1; FGFR3; KRAS; SOS1; PRKAA2; IFNA6; RPS6; EIF4E1B; LAMB3
AMPK signaling pathway
FOXO3; SIRT1; PRKAA1; RAB10; STRADB; CFTR; PIK3CA; PPP2R1A; EIF4EBP1; G6PC
Apoptosis
CASP6; DYNLL2; RIPK1L; PKP1; IL1RAP; H1F0; CTNNB2; IRF1B; CFLAR; HIST1H1E
Adrenergic signaling in cardiomyocytes
CAMK2D1; CAMK2A; ADRB2B; PPP2R5EA; MAPK14; TPM4B; CALM1A; PPP1R1A; PLCB3; RAPGEF4
VEGF signaling pathway
RAC1; PIK3CA; PLA2G4C; PLCG2; MAPK11; PTK2AA; PRKCG; VEGFAB; RAC2; PLA2G4D
Osteoclast differentiation
PIK3CG; AKT2; SPI1; TGFB2; FCGR2C; PIK3CA; FOSL2; MITF; CYLD; cgr2b
Focal adhesion
ROCK2; ITGA3; RAF1; ACTN3; ROCK1; LAMB1; MYLK4; GRB2A; SHC2; BAD
Signaling pathways regulating pluripotency of stem cells
PIK3R1; FZD1; WNT4; ZFHX3; KLF4; Fzd4; SMAD3; MAPK11; JARID2; TBX3
Platelet activation
GNAI2; GNAQ; PPP1CB; COL24A1; PIK3R1; AKT1; MAPK12; ITPR3; FGG; PTGIR
Toll-like receptor signaling pathway
TLR2-1; IFNPHI3; MAPK10; MAP2K7; IFNB; IL8L2; CCL5; TLR1; IFNA3; PIK3CG
Jak-STAT signaling pathway
GH2; Il23a; Il12b; PTPN2B; IL17D; IL4; IFNGR2; CCND1; SOS1; CRFB2; RAF1
Natural killer cell mediated cytotoxicity
IFNA6; NRAS; KLRC3; NCR3; FASLG; IFNGR1; FAS; PIK3CD; NFATC1; PIK3CB
T cell receptor signaling pathway
RAF1; EVLB; GRB2; VAV2; CD247; PIK3CB; PIK3CG; SHB; PPP3CB; NCK1
B cell receptor signaling pathway
IKBKB; CD22; ARPC3; KRAS; SOS1; RAP2A; NEDD9; RAC3; PIK3R2; VAV2
Fc epsilon RI signaling pathway
MAP2K7; RAF1; PIK3CB; MAP2K1; LYN; PIK3R1; MAPK11; VAV3; LAT; PRKCA
Fc gamma R-mediated phagocytosis
MARCKS; CDC42; WASL; PRKCB; FCGR2A; LAT; PIK3CB; PLD2; GSN; AKT2
TNF signaling pathway
MAPK3; CCL2; NFKBIA; MMP3; CFLAR; Ccl12; MAPK9; BCL3; IL6; PIK3R1
Leukocyte transendothelial migration
ROCK2; PTK2B; RAC2; GNAI1; PXN; MAPK12; CLDN2; OCLN; MMP2; F11R
Neurotrophin signaling pathway
NTF3; ARHGDIA; SHC3; IRS1; BAD; PIK3R5; RPS6KA5; MAP2K7; MAPK7; BRAF
Cholinergic synapse
FOS; CHRM2; GNGT2; GNG7; ITPR3; GNGT1; NRAS; Adcy4; KCNJ4; GNB2
Inflammatory mediator regulation of TRP channels
PTGER4; CALML3; MAPK13; CAMK2A; CYP2C37; PLA2G6; CYP4A14; ALOX12; CYP2J6; TRPV2
Regulation of actin cytoskeleton
ENAH; MYH10; FGFR2; PIP4K2AA; RAC3; FGF21; ITGAL; ITGA3B; ITGA4; Itga10&Itgb1
Insulin signaling pathway
CALM3B; PPARGC1A; CBLB; PPP1R3D; PKLR; INS1; ACACB; INS2; INPPL1; PRKAG2
Progesterone-mediated oocyte maturation
RAF1; INS2; PIK3CA; RAF1B; MAPK8A; CCNA1; MAPK12; PIK3R5; CDC27; RPS6KA2
Estrogen signaling pathway
HSP90B1; GRB2; PIK3CA; PIK3R3; MMP2; CALML3; HRAS; HSPA6; KCNJ9; HSPA1A
Prolactin signaling pathway
PIK3CG; SOCS1; PIK3CA; STAT5A; LHCGR; FOXO3; HRAS; CCND2; KRAS; MAPK12
Thyroid hormone signaling pathway
SIN3A; ATP1B4; PRKACB; PIK3R5; PRKCG; STAT1; PLCB2; RAF1; PRKACG; THRB
Oxytocin signaling pathway
RYR2; GUCY1B3; CAMK2A; ACTB; HRAS; MAP2K5; GNAS; ACTG1; PIK3CD; CACNG1
Regulation of lipolysis in adipocytes
PRKACG; NPR1; PIK3CG; INS; GNAI3; INS1; PIK3CD; PIK3CA; PRKACA; PRKG2
Type II diabetes mellitus
PIK3CD; SOCS3; PIK3R1; PRKCZ; MAPK1; SLC2A2; MAPK8; PDX1; HK1; INS2
Insulin resistance
MTOR; MAPK10; PIK3CG; PTENA; TNFRSF1A; PRKCBB; PPARAB; INSB; PYGL; PDPK1
Non-alcoholic fatty liver disease (NAFLD)
NDUFS1; NDUFA9; NDUFS8; ADIPOR2; NDUFA12; GSK3B; NDUFA6; PRKAG2; PRKAG3; SDHC
Aldosterone-regulated sodium reabsorption
PRKCG; KRAS; KCNJ1; INS; PRKCA; PDPK1; ATP1B3; FXYD4; INS1; PIK3R3
Carbohydrate digestion and absorption
PIK3R1; AMY2A; SLC2A5; AKT1; PRKCB; FXYD2; ATP1B1; PIK3R2; G6PC; SI
Bacterial invasion of epithelial cells
CDH1; SEPT12; CBL; VCL; PIK3CD; MAD2L2; PIK3R5; ARPC2; SEPT9; ELMO1
Chagas disease (American trypanosomiasis)
IL1B; GNAS; PPP2R2B; GNAQ; GNAL; PLCB2; MAPK8; CCL3L1; NOS2; IRAK1
Toxoplasmosis
TRAF6; IL10RB; BCL2L1; STAT3; Toxoplasma Gondii Dense Granule Protein 7; Toxoplasma Gondii Microneme Protein MIC3; IL10RA; AKT2; MAPK11; GNAI3
Amoebiasis
ADCY1; C8G; CTSG; RELA; ITGAM; SERPINB13; COL4A1; SERPINB3; PIK3R3; GNA11
Hepatitis C
IFNB1; LDLR; BRAF; IFNA7; CLDN3; CLDN1; AKT1; TNFRSF1A; PPARA; MAVS
Hepatitis B
DDX3X; IFNAR1; IFNA10; Fasl; AKT1; MAPK9; IFNA21; IFNA8; FASLG; CREB3L3
Measles
OAS1B; MSN; NFKBIB; IFNA12; IL6; DOK1; TLR9; IL4; cgr2b; IRF3
Influenza A
RAF1; TNFSF10; IFNA17; PABPN1; PRSS1; TNFRSF10D; GSK3B; MAPK8; KPNA2; TLR7
HTLV-I infection
HLA-E; GSK3B; IL2RG; SPI1; HLA-DQB1; KAT2A; HLA-DPB1; XPO1; EP300; TRP53
Epstein-Barr virus infection
POLR2H; HLA-DQA1; YWHAZ; HLA-G; TRAF3; PSMD3; IL10RB; HSPB2; TRP53; PIK3R1
Pathways in cancer
TPM3; SMAD4; TFG; LAMA2; RELA; SFPI1; MECOM; PRKACA; FGF7; PRKCA
Viral carcinogenesis
HIST1H4F; GTF2A1; PIK3CA; GRB2; HIST1H2BH; HIST1H4B; SKP2; HLA-G; ACTN3; HIST2H2BE
Proteoglycans in cancer
RRAS; FASLG; CAMK2B; FZD9; PDPK1; WNT2; PLAUR; PRKACA; CAV2; SDC4
Colorectal cancer
RALGDS; PIK3R3; BIRC5; RAC2; PIK3R1; BCL2; ARAF; GSK3B; SMAD4; RHOA
Renal cell carcinoma
PAK1; PIK3CB; MAPK3; PDGFB; ARAF; HRAS; ARNT2; PIK3R3; RAPGEF1; PIK3R1
Pancreatic cancer
TP53; TGFBR2; MAPK3; SMAD2; PIK3R5; RB1; MAPK9; IKBKG; CDC42; PIK3CA
Endometrial cancer
GSK3B; ILK; CDH1; ELK1; LEF1; MLH1; ERBB2; MAP2K1; PIK3R2; MAPK3
Glioma
TRP53; CAMK2G; TGFA; AKT2; IGF1; PRKCB; TP53; CALML5; HRAS; PLCG2
Prostate cancer
TCF7L2; CREB5; IKBKG; NDRG1; Ar; PIK3R1; KRAS; TP53; MAP2K1; NKX3-1
Melanoma
PDGFC; AKT2; PIK3R1; FGF1; IGF1; FGF14; FGF22; PIK3CB; MAPK3; FGF9
Chronic myeloid leukemia
AKT1; SHC2; BAD; CRKL; BRAF; RELA; PTPN11; TGFBR1; BCR; KRAS
Acute myeloid leukemia
JUP; MAPK1; IKBKG; RAF1; CHUK; PIM2; CCNA1; FLT3; CCND1; RPS6KB1
Small cell lung cancer
AKT1; PIK3CG; APAF1; CKS2; LAMA2; PTGS2; PIK3CD; LAMB3; TP53; CYCS
Non-small cell lung cancer
MAP2K2; PLCG2; GRB2; CCND1; CASP9; PIK3CB; STK4; RXRG; FHIT; SOS1
Central carbon metabolism in cancer
KIT; FGFR1; MET; HK3; PFKM; PIK3R2; HRAS; MTOR; RAF1; MAP2K2
Choline metabolism in cancer
DGKB; PLD1; SLC44A2; MAPK10; PIK3R1; MTOR; WAS; DGKD; RPS6KB1; PIP5K1B

Protein Function

PIK3R3 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R3 itself. We selected most functions PIK3R3 had, and list some proteins which have the same functions with PIK3R3. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3CD; PIK3CG; PIK3CB; PIK3C2A; ATM; PIK3C2G; PIK3CA; PIK3R3; PIK3C3; PIK3C2B
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein PIK3R3; PIK3R1; CCKBR; PIK3R6; PIK3R3A; PIK3R5; PIK3R3B; PIK3R2
Function protein binding
Related Protein MEN1; PPP3R1; EPB49; CLDN18; HTR3C; RPL10A; ZNF652; POC1A; SMG5; GGACT

Interacting Protein

PIK3R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R3.
EGFR; PIK3CA; PTK2; SRC; CRK; PLEKHS1