pik3r3
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
  • Background
  • Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme that in humans is encoded by the PIK3R3 gene.
  • Synonyms
  • PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphatidylinositol 3-kinase regulatory subunit gamma; p55; p55PIK; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; 100% homology to SWISS-PROT Q92569; PI3-kinase regulatory su
Cat.#:PIK3R3-4464RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIK3R3 Protein
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Cat.#:PIK3R3-3436RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R3 Protein, His-tagged
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Cat.#:PIK3R3-3184HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3R3 293 Cell Lysate
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Involved Pathway

PIK3R3 involved in several pathways and played different roles in them. We selected most pathways PIK3R3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
CAMK2G; MAPK8A; PIK3CB; PIK3R5; MAP2K2B; PIK3R3; ERBB4; CDKN1BA; PIK3CD; MAP2K4
Ras signaling pathway
RASAL2; FGF14; PIK3CD; HGF; ARF6; PIK3CG; FLT4; IKBKB; RAB5C; GNB3
Rap signaling pathway
LPAR5; GNAI1; PDGFA; PLCB2; FGF3; Itgam&Itgb2; RAP1A; INS1; VAV2; ITGB2L
cGMP-PKG signaling pathway
GNAI3; PLCB2; INS1; PIK3CG; VDAC1; TRPC6; ITPR3; ATF4; INSR; ITPR1
cAMP signaling pathway
RAP1A; SLC9A1; PDE3A; HCN2; GRIN2C; CAMK2D; GLP1R; BRAF; HCAR3; PTGER3
Chemokine signaling pathway
PIK3R5; CCL14; CCL15; CXCL11; XCL1; CXCR4; VAV2; STAT2; CCL22; AMCF-II
HIF- signaling pathway
PFKL; PIK3R2; NOS3; PRKCA; TFRC; RELA; MKNK1; LTBR; VEGFA; PDHA1
FoxO signaling pathway
G6PCA.1; INS2; PRKAG3; CCNB2; PRMT1; HOMER1B; MAPK8A; PDPK1B; IGF1RB; GADD45G
Phosphatidylinositol signaling system
IP6K3; PIK3C3; IP6K2; PIK3CA; PLCD3; PLCG1; INPPL1; PIP5K1AA; CALM2A; MTMR14
Sphingolipid signaling pathway
DEGS1; BCL2; PIK3R5; KRAS; RAC1; RELA; SGPP2; PPP2R5A; SPHK1; TRP53
Phospholipase D signaling pathway
PLA2G4C; CXCR2; MTOR; GAB2; PLCG2; SYK; DNM3; DGKZ; PPAP2C; CYTH3
mTOR signaling pathway
HIF1A; AKT1S1; PIK3CA; PRKCBB; BRAF; EIF4E1B; MTOR; TNF; MAPK1; RRAGCB
PIK-Akt signaling pathway
TNN; PPP2R3C; HSP90AB1; FGF19; IBSP; IL2RB; ITGA5; PKN2; LPAR2; GHR
AMPK signaling pathway
INS; SREBF1; PPP2R2D; CCNA1; AKT2; PRKAB2; PPP2R2A; CAMKK1; FBP2; AKT1
Apoptosis
PIK3R3A; JUN; DFFB; DBNLA; IL1RAP; BIRC3; CASP7; STK24; DIABLOB; CASP3A
Adrenergic signaling in cardiomyocytes
TPM3; GNAI1; CACNB2A; CACNA2D3; PLCB4; CACNB3A; ATP1B2; CAMK2D; GNAI3; CACNG2
VEGF signaling pathway
PLA2G4C; MAPK14B; PPP3CCB; CDC42; BADB; CASP9; PTGS2B; PTK2; MAP2K2; PLA2G4F
Osteoclast differentiation
SIRPG; PIK3R3; MAPK3; LCK; FOSB; LILRB2; TGFBR1; STAT2; RELB; IFNB1
Focal adhesion
MYL10; PRKCG; VTNB; COL27A1B; MLCK2; PRKCBB; ZYX; HGF; ACTN3B; RAF1B
Signaling pathways regulating pluripotency of stem cells
WNT11; PCGF5; FZD3; INHBC; BMP2; FGFR3; MAPK13; FZD5; IGF1R; FGF2
Platelet activation
RAP1A; PIK3R2; PTGIR; PLCB2; COL27A1; PLCG2; PLCB1; MYLK4; FCER1G; FYN
Toll-like receptor signaling pathway
LBP; IFNA7; TLR1LA; IFNA2; TLR9; IKBKE; IFNA16; MAP2K2A; MAP2K6; TOLLIP
Jak-STAT signaling pathway
PIK3R3; SOCS6; IFNA3; AOX1; PIK3R1; IL28RA; CRFB4; CCND1; Gh; CCND3
Natural killer cell mediated cytotoxicity
KLRA8; ITGB2L; PRF1; IFNA17; ULBP1; LAT; IFNA14; Fasl; KIR2DL4; NFATC2
T cell receptor signaling pathway
PIK3R1; OXSR1A; GRAPA; MAPK12; CD40LG; PIK3CB; MAP2K2; PIK3R3; PTPN6; CBL
B cell receptor signaling pathway
INPP5D; RAC2; TTC6; PIK3CA; FOS; FCGR2B; PPP3R1; AKT1; PIK3R1; PPP3CA
Fc epsilon RI signaling pathway
MAP2K6; PLCG1; LYN; PLA2G4C; IL5; SOS1; GM-CSF; MAP2K2; PLCG2; PIK3R1
Fc gamma R-mediated phagocytosis
PRKCE; ASAP3; LAT; SPHK2; CDC42; SCIN; ARPC1A; MAPK1; RPS6KB2; ARF6
TNF signaling pathway
MMP9; FADD; LIF; RELA; MLKL; IKBKG; FOS; FAS; TAB2; MAPK3
Leukocyte transendothelial migration
PIK3R5; ACTG1; BCAR1; MYL9; NOX3; PIK3CB; ROCK1; CYBA; MSN; ITGAL
Neurotrophin signaling pathway
MAP3K5; CALM2; ARHGDIG; NRAS; NGFRAP1; RIPK2; CALML5; CALM4; SH2B3; NGF
Cholinergic synapse
CAMK4; AKT2; JAK2; CHRM4; MAP2K1; CREB5; CAMK2G; MAPK1; ATF4; GNAI1
Inflammatory mediator regulation of TRP channels
CYP2J2; GNAS; PRKCA; PRKCD; CYP2C37; PTGER4; IL1R1; IGF1; CYP2C54; CYP4A14
Regulation of actin cytoskeleton
ARAF; SCINLB; PIP4K2A; GIT1; PIP5K1AB; BRK1; Fgf15; ACTB2; PIP5K1A; ARHGEF6
Insulin signaling pathway
MAPK8A; MAP2K2B; MTOR; SHC3; PIK3R2; PPP1CBL; PPP1R3B; TSC1B; ELK1; PIK3R3A
Progesterone-mediated oocyte maturation
CDC25C; MOS; GNAI3; CCNB2; ANAPC1; ADCY1B; ANAPC13; ANAPC2; PRKACBA; BRAF
Estrogen signaling pathway
MMP2; PIK3R2; HSPA1L; FKBP5; GRB2; SHC3; GNAI1; MMP9; HSPA1B; HSP90AA1
Prolactin signaling pathway
STAT3; PIK3R5; GALT; ELF5; SOCS6; NFKB1; FOS; INS2; KRAS; MAPK11
Thyroid hormone signaling pathway
RCAN1; HDAC2; TBC1D4; MAPK1; PIK3CD; PLCZ1; MED30; SRC; KRAS; MAPK3
Oxytocin signaling pathway
PPP1R12C; NPR2; PRKAB1; PRKACB; PLCB3; NFATC2; CALM2; HRAS; MAP2K2; EEF2K
Regulation of lipolysis in adipocytes
Adcy4; INS2; AKT1; PIK3CB; LIPE; FABP4; PDE3B; PRKACA; TSHB; PIK3CA
Type II diabetes mellitus
IRS4; SOCS2; PIK3CD; PIK3CB; HKDC1; PIK3R5; PKLR; HK3; SOCS3; PIK3CG
Insulin resistance
PPP1R3CA; PRKAB2; G6PC2; AKT2; RPS6KA2; CREB3L1; PPP1R3DA; FOXO1B; GFPT1; RELA
Non-alcoholic fatty liver disease (NAFLD)
PRKAG1; COX7B2; PIK3CA; NDUFV1; PIK3R2; NDUFS6; NDUFA13; IL1B; Casp3; NDUFB3
Aldosterone-regulated sodium reabsorption
IRS1; MAPK1; KRAS; PIK3CA; PIK3CB; SFN; ALPHA-ENAC; NEDD4L; PRKCA; ATP1A1
Carbohydrate digestion and absorption
PIK3CG; PIK3CB; AKT1; TAS1R3; HK1; ATP1A3; GNAT3; PIK3R5; PRKCB; AMY2A2
Bacterial invasion of epithelial cells
CAV1; SEPT1; PIK3CD; PIK3R2; CDH1; CTNNA3; PIK3R3; CRKL; CDC42; GAB1
Chagas disease (American trypanosomiasis)
FAS; CFLAR; C1QB; PLCB1; MAP2K4; CD3D; PIK3R3; PIK3CA; IFNGR2; TGFBR1
Toxoplasmosis
MAPK13; MAP2K3; IFNGR1; IKBKB; TNFRSF1A; HSPA6; BCL2L1; ITGA6; HSPA1L; TNF
Amoebiasis
GNAS; Itgam&Itgb2; COL24A1; PTK2; IL1R1; PRKCG; COL4A5; HSPB1; RAB5B; TGFB1
Hepatitis C
PIK3CA; MAPK13; STAT3; PIK3CD; CLDN8; CLDN23; IFNB1; PIK3R5; CLDN6; CLDN18
Hepatitis B
MAP2K2; NFKB1; IFNA21; CREB3L3; FADD; Fasl; CCNA1; GRB2; MAP2K1; IFN-a
Measles
IL12B; TNFRSF10C; TBK1; TLR7; IRAK1; IL2RB; PIK3R5; TNFRSF10B; STAT1; HSPA1A
Influenza A
MAPK10; BMA2; TNFSF10; KPNA2; NXF3; STAT2; VDAC1; BCL2L2-PABPN1; BLA; IRF7
HTLV-I infection
ANAPC5; CDC16; HLA-DQA2; SLC25A5; ETS1; PIK3R5; WNT4; CCNB2; ANAPC7; PDGFB
Epstein-Barr virus infection
POLR2J; PSMD12; NFKBIA; MDM2; BCL2; HLA-C; MAP2K7; PIK3R2; EIF2AK4; NCOR2
Pathways in cancer
MET; PRKACB; PPARG; VHL; DAPK1; HSP90AA1; CYCS; RASSF1; ITGAV; CUL2
Viral carcinogenesis
HIST1H4B; TBPL2; GTF2H2C; NFKB1; UBR4; DNAJA3; POLB; HDAC4; MAD1L1; HIST1H2BH
Proteoglycans in cancer
GRB2; ACTG1; RAF1; TP53; AKT1; PRKACA; SOS1; DDX5; VEGFA; SMO
Colorectal cancer
BAX; SMAD4; PIK3CB; BRAF; TGFB3; PIK3R3; TGFB1; TRP53; MAPK10; BCL2
Renal cell carcinoma
PAK3; TCEB2; NRAS; TCEB1; PIK3R2; VHL; PAK6; GAB1; CUL2; FH1
Pancreatic cancer
RAF1; BCL2L1; NFKB1; PLD1; RALGDS; MAP2K1; RAC1; CASP9; TGFB1; SMAD3
Endometrial cancer
TCF7; PIK3CA; MAP2K2; PIK3CB; AXIN2; TRP53; ARAF; CTNNA3; TCF7L2; KRAS
Glioma
CAMK2D; AKT1; PDGFRA; RB1; ARAF; GRB2; MDM2; PRKCB; MAPK3; SHC2
Prostate cancer
SRD5A2; PDGFD; PTEN; INSRR; NRAS; NOXA1; CCNE1; MAPK3; BRAF; EP300
Melanoma
MAP2K1; BRAF; FGF4; FGF17; FGF19; FGF7; CDH1; PIK3R5; PIK3R1; TRP53
Chronic myeloid leukemia
BCL2L1; MAPK3; TP53; NFKB1; TGFBR2; AKT1; MAP2K2; PIK3R2; MAPK1; SHC3
Acute myeloid leukemia
PIK3CD; IKBKB; STAT5A; MAPK3; SOS1; CCNA1; KIT; RUNX1; TCF7L2; BAD
Small cell lung cancer
ITGA6; RB1; NFKB1; ITGA3; TRP53; SKP2; BCL2L1; IKBKG; BIRC2; CCNE1
Non-small cell lung cancer
RAF1; RARB; PRKCA; MAP2K2; PDPK1; TGFA; PRKCG; PIK3CD; RB1; TP53
Central carbon metabolism in cancer
HK3; HK1; PIK3R3; MAPK1; PDGFRB; LDHA; PKM; PFKM; PTEN; MET
Choline metabolism in cancer
SLC22A5; AKT1; PRKCA; PIP5K1C; PLA2G4D; PLA2G4C; PIK3CA; DGKE; CHKA; SLC22A2

Protein Function

PIK3R3 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R3 itself. We selected most functions PIK3R3 had, and list some proteins which have the same functions with PIK3R3. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3CD; PIK3R3; PIK3CB; PIK3CG; ATM; PIK3C2G; PIK3C3; PIK3C2A; PIK3CA; PIK3C2B
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein PIK3R3A; PIK3R3; PIK3R6; PIK3R5; CCKBR; PIK3R3B; PIK3R2; PIK3R1
Function protein binding
Related Protein RET; ZNF821; CBFB; SLC25A4; LGALSL; IRF4; NRF1; SEC22C; GPANK1; HPRT1

Interacting Protein

PIK3R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R3.
EGFR; PIK3CA; PTK2; SRC; CRK; PLEKHS1