PIK3R3
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Official Full Name
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
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Overview
Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme that in humans is encoded by the PIK3R3 gene. -
Synonyms
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphatidylinositol 3-kinase regulatory subunit gamma; p55; p55PIK; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; 100% homology to SWISS-PROT Q92569; PI3-kinase regulatory su;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
PIK3R3 involved in several pathways and played different roles in them. We selected most pathways PIK3R3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | STAT5A;PAK2;PRKCG;ERBB2;MAP2K2;PAK1;ERBB3A;CAMK2B;CAMK2D1 |
| Ras signaling pathway | GNG7;ANGPT2;FLT1;FGF5;RIN1;FLT4;ETS2;SHC3;GAB1 |
| Rap signaling pathway | MAPK11;RASSF5;FGF2;PRKD3;RAPGEF1;MAPK3;BRAF;PFN3;FGF20 |
| cGMP-PKG signaling pathway | NOS3;PDE3B;PPP3CB;SLC25A5;ROCK2;MYLK;ATP2A2;CALM3;NPR1 |
| cAMP signaling pathway | RYR2;CREB3L2;HCAR2;MLLT4;PLN;CALML3;GRIA3;CALML5;PPARA |
| Chemokine signaling pathway | CXCL13;RAC1;CCL8;CCL14;CCR1;PPBP;PIK3R1;CXCR1;GM2506 |
| HIF- signaling pathway | PDHA2;NOX1;CAMK2A;VEGFA;RPS6KB2;NOX3;HIF1A;RBX1;ENO1 |
| FoxO signaling pathway | PIK3R2;BNIP4;CAT;PIK3CG;AGAP2;HOMER1;SKP2;FOXO4;PDPK1 |
| Phosphatidylinositol signaling system | PIK3R3;INPP5B;PLCD3A;DGKD;PRKCB;PRKCBB;CDS2;PIK3CA;PRKCG |
| Sphingolipid signaling pathway | GNAQ;MAPK1;SGMS1;TRADD;SGPL1;GNA12;MAPK10;PPP2R3A;PPP2CA |
| Phospholipase D signaling pathway | RHOA;SHC2;AVPR2;KRAS;DGKZ;RALB;PLA2G4D;PLCB2;AKT1 |
| mTOR signaling pathway | PIK3R5;PIK3R1;RPS6KB2;PRR5;CAB39;PRKCBA;RPS6KA2;DDIT4;DEPDC6 |
| PIK-Akt signaling pathway | PPP2R2B;IL4R;MAPK3;SGK3;SYK;PIK3R5;PIK3R2;IFNA17;CREB3L3 |
| AMPK signaling pathway | AKT1S1;CREB3L3;PIK3R1;EEF2;PRKAB1;PFKFB2;LEPR;ADIPOQ;INS1 |
| Apoptosis | MYC;CASP10;HIST1H1D;NMT1;TICAM1;BNIP3L;CASP3B;PIK3R3A;PLEC |
| Adrenergic signaling in cardiomyocytes | CALM1;ATP1A3;GNAI2;TPM4A;ADCY9;AGTR1B;TNNC1B;PIK3R3;TNNT2 |
| VEGF signaling pathway | PLCG2;PTGS2A;AKT2;MAPK1;MAP2K1;AKT1;RAC1A;MAP2K2A;PIK3R3 |
| Osteoclast differentiation | MAPK1;FOSB;TNFRSF1A;MAP2K7;FCGR2C;TNF;PPP3CB;STAT2;PIK3R3 |
| Focal adhesion | TESK2;SHC3;PIK3CA;COL2A1B;XIAP;ROCK2A;TNK2;MAPK4;CHAD |
| Signaling pathways regulating pluripotency of stem cells | MAPK3;WNT7A;PCGF2;FGFR2;SKIL;HESX1;FZD8;WNT10B;PIK3R3 |
| Platelet activation | P2RY1;P2RY12;VWF;GUCY1B3;VASP;MYL12B;PLA2G4C;FGG;FYN |
| Toll-like receptor signaling pathway | TNF;TBK1;TLR5;IFNA10;CXCL10;CXCL9;PIK3R1;MAP2K3;TLR4 |
| Jak-STAT signaling pathway | FHL1;AOX2P;M17;IFNL3;STAM2;IFNA1;PIAS4B;PRLR;CRFB16 |
| Natural killer cell mediated cytotoxicity | SH2D1B;IFNA6;PTPN11;HRAS;PRKCB;KIR3DL1;MICB;SOS1;BID |
| T cell receptor signaling pathway | PIK3CA;RAF1;IFNG;AKT2;PIK3R1;MAPK13;MAPK3;ZAP70;CD8A |
| B cell receptor signaling pathway | MAPK1;CRKL;CTNNB2;VAV3;RAF1;ARPC2;NRAS;CD79A;CD79B |
| Fc epsilon RI signaling pathway | IL3;VAV1;RAC2;FYN;LCP2;GAB2;MAPK9;MAPK1;MAPK8 |
| Fc gamma R-mediated phagocytosis | GAB2;PLA2G4D;VAV3;PAK1;WASF3;PLA2G4F;PIK3R2;PIK3R1;SYK |
| TNF signaling pathway | CFLAR;Casp3;MAP3K7;PIK3CA;BIRC2;TRAF1;CCL2;BIRC3;SELE |
| Leukocyte transendothelial migration | JAM3;CLDN3;MYL12B;PRKCA;MYL5;GNAI2;TXK;CDC42;ITGAL |
| Neurotrophin signaling pathway | IRAK4;NGFR;PSEN1;RELA;SH2B2;RAF1;PIK3CG;NTF3;IRAK1 |
| Cholinergic synapse | AKR1C1;KCNQ5;KCNJ4;GNGT1;PIK3R3;CHRM1;GNG12;KCNJ2;CREB3L3 |
| Inflammatory mediator regulation of TRP channels | ACCN4;CYP2C50;BDKRB1;CYP2C55;PRKCQ;PIK3CA;PIK3R2;MAP2K3;PRKCB |
| Regulation of actin cytoskeleton | LIMK1A;IQGAP2;FGF5;PDGFA;ACTB1;FGFR3;PXN;MYLPFA;FGF1B |
| Insulin signaling pathway | PPP1CC;RAPGEF1;RAF1;PRKAG3B;EIF4E2RS1;FLOT2;MAP2K1;SLC2A4;PRKAA2 |
| Progesterone-mediated oocyte maturation | CDC25B;PIK3R3A;GNAI2A;CCNB1;AKT3A;IGF1R;PPP1R2P9;PIK3R1;GNAIA |
| Estrogen signaling pathway | KCNJ3;HSP90AA1;KCNJ9;HSPA1L;SHC1;PIK3CD;PIK3R5;GNAS;SOS1 |
| Prolactin signaling pathway | MAPK12;STAT5A;STAT5B;SOCS6;MAPK13;SHC3;SOS1;CCND1;MAPK10 |
| Thyroid hormone signaling pathway | ATP1A3;GSK3B;DIO3;PLCG1;MDM2;BMP4;RXRB;PIK3R1;PRKACB |
| Oxytocin signaling pathway | ROCK1;NFATC4;RYR1;PRKAG2;CD38;MYL6;CAMK2G;PIK3R1;GNAS |
| Regulation of lipolysis in adipocytes | PTGER3;GNAI3;NPY1R;AKT2;PNPLA2;PIK3CG;INS1;AQP7;TSHB |
| Type II diabetes mellitus | PKLR;ADIPOQ;PRKCD;SOCS4;IRS2;PRKCE;HK1;INS2;PIK3CA |
| Insulin resistance | RPS6KB1;PRKAG3;RPS6KA6;PIK3R3A;SLC2A1;FOXO1B;NR1H2;CRTC2;PIK3R5 |
| Non-alcoholic fatty liver disease (NAFLD) | UQCRC1;PRKAG2;LEP;ATF4;FAS;AKT1;IRS1;CDC42;NDUFAB1 |
| Aldosterone-regulated sodium reabsorption | ATP1A3;MAPK3;SGK1;NR3C2;NEDD4L;PIK3R5;PIK3CG;PIK3R3;ATP1A1 |
| Carbohydrate digestion and absorption | HK2;PLCB2;SLC2A2;ATP1A3;PIK3R2;FXYD2;ATP1B3;TAS1R2;HK3 |
| Bacterial invasion of epithelial cells | DNM1;WASF1;CLTC;SEPT12;WASL;BCAR1;FN1;PIK3CA;ILK |
| Chagas disease (American trypanosomiasis) | PPP2R2C;MAPK8;Il2;TRAF6;MAPK10;IL12B;GNA15;CCL2;TGFBR2 |
| Toxoplasmosis | IFNGR1;PIK3R3;HLA-DRB3;STAT1;LAMC2;IL10RA;GNAI2;Toxoplasma Gondii Dense Granule Protein 7;PIK3R5 |
| Amoebiasis | C9;CTSG;COL24A1;IL1B2;LAMA5;PIK3CG;PRKACB;SERPINB1;LAMC2 |
| Hepatitis C | TNF;CLDN15;IL-8;CLDN23;PPP2R2A;RELA;EIF2AK1;TYK2;PIK3R2 |
| Hepatitis B | GRB2;TGFB2;OSTN;NFATC4;PIK3R3;IFNA13;YWHAB;DDX58;HRAS |
| Measles | IRF7;BBC3;IFNA6;IFIH1;CD3D;IFNA17;IL12A;PIK3R3;MX1 |
| Influenza A | FDPS;IFNA17;HLA-DRB1;IFNA10;OAS1B;IKBKB;IFNAR1;IFNA5;Ifna15 |
| HTLV-I infection | HLA-E;PDGFB;DLG1;ZFP36;Adcy4;WNT16;PDGFRA;POLB;SLC25A4 |
| Epstein-Barr virus infection | TRAF1;MAP2K6;RELB;PIK3R1;NUP214;CDK1;TAB1;POLR2J3;GTF2B |
| Pathways in cancer | BIRC5;Fgf15;CXCR4;FZD1;RALGDS;ROCK1;ITGA2B;GNAI3;TCF7L2 |
| Viral carcinogenesis | TTC6;STAT5A;HIST1H2BH;NFKB1;KRAS;CASP8;HIST1H2BK;CCNE2;HIST2H4A |
| Proteoglycans in cancer | HIF1A;ITGA5;CAMK2B;Fzd4;LUM;ACTG1;PXN;CBLC;HGF |
| Colorectal cancer | MAPK3;BAX;FOS;AKT1;PIK3CA;CYCS;MLH1;LEF1;TGFBR2 |
| Renal cell carcinoma | TGFB1;FLCN;MAP2K2;RAP1A;PIK3R3;MET;PIK3CA;MAP2K1;ARAF |
| Pancreatic cancer | KRAS;PIK3R5;PIK3R1;RAC2;TRP53;RALBP1;BAD;RELA;PIK3CA |
| Endometrial cancer | PTEN;PIK3CB;BAD;ARAF;HRAS;APC;NRAS;TP53;MAPK1 |
| Glioma | CALML3;CAMK2D;SHC2;NRAS;IGF1R;TRP53;MAP2K2;CALM3;MAPK3 |
| Prostate cancer | MAPK3;LEF1;ERBB2;INS2;CREB3L3;SPRY1;MDM2;CREB3L1;PIK3CB |
| Melanoma | FGF8;PDGFC;FGF17;MAP2K1;PIK3R5;FGF1;FGF5;RB1;PTEN |
| Chronic myeloid leukemia | CRKL;HRAS;SMAD3;BRAF;BCR;CRK;RELA;NFKB1;MAP2K2 |
| Acute myeloid leukemia | MAP2K2;PPARD;NFKB1;RUNX1;RPS6KB2;LEF1;RAF1;SFPI1;GRB2 |
| Small cell lung cancer | PTGS2;LAMC2;RELA;LAMA1;TRAF1;TRAF4;PIK3CA;NOS2;SKP2 |
| Non-small cell lung cancer | RXRG;RB1;MAPK1;BRAF;PIK3CG;PIK3CB;SOS1;HRAS;TRP53 |
| Central carbon metabolism in cancer | FLT3;MTOR;MAPK3;ERBB2;KRAS;PGAM1;GLS2;SLC1A5;NTRK3 |
| Choline metabolism in cancer | EGF;PIP5K1A;GPCPD1;SLC22A5;PDGFD;PPAP2C;SLC22A2;HRAS;MAP2K1 |
PIK3R3 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R3 itself. We selected most functions PIK3R3 had, and list some proteins which have the same functions with PIK3R3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-3-kinase activity | PIK3C2G;PIK3R3;PIK3CA;PIK3CB;PIK3CD;PIK3C2A;PIK3C3;PIK3CG;ATM |
| 1-phosphatidylinositol-3-kinase regulator activity | PIK3R3A;PIK3R3B;PIK3R3;PIK3R1;PIK3R5;PIK3R2;PIK3R6;CCKBR |
| protein binding | AHCY;XRN1;SOX13;ZC4H2;NEK1;FAM110A;NEUROD1;RBM11;GTF2A1L |
PIK3R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R3.
EGFR; PIK3CA; PTK2; SRC; CRK; PLEKHS1
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