pik3r3
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
  • Background
  • Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme that in humans is encoded by the PIK3R3 gene.
  • Synonyms
  • PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphatidylinositol 3-kinase regulatory subunit gamma; p55; p55PIK; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; 100% homology to SWISS-PROT Q92569; PI3-kinase regulatory su
Cat.#:PIK3R3-4464RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIK3R3 Protein
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Cat.#:PIK3R3-3436RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R3 Protein, His-tagged
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Cat.#:PIK3R3-3184HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3R3 293 Cell Lysate
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Involved Pathway

PIK3R3 involved in several pathways and played different roles in them. We selected most pathways PIK3R3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
MAP2K1; PRKCG; ERBB2; PTK2AB; SRC; CAMK2D; KRAS; PIK3R3B; AKT2; ARAF
Ras signaling pathway
GNG12; ANGPT4; PDGFC; GNG3; RAP1A; NFKB1; KITLG; FGF6; RALGDS; TEK
Rap signaling pathway
Adcy4; PIK3R3; CDC42; MET; PLCE1; IGF1; FGFR3; VASP; LCP2; MLLT4
cGMP-PKG signaling pathway
GTF2I; PIK3R2; PLCB3; MEF2B; PDE2A; SLC25A31; KCNJ8; ATP1B3; GNA11; PPP3R1
cAMP signaling pathway
PDE4B; DRD1A; CAMK2D; CNGA3; GHRL; PLD1; GRIA1; GRIA2; PTGER2; RAC1
Chemokine signaling pathway
CCL4L2; CCR1L1; CCL13; PPBP; GSK3B; CXCL16; GNG8; CCL5; XCL2; PRKACA
HIF- signaling pathway
ENO3; TFRC; SERPINE1; Trf; PIK3R2; MKNK1; VEGFA; ENO1; TIMP1; IFNG
FoxO signaling pathway
FOXO1; PIK3R1; GADD45AA; PRKAG2; TGFBR2; CCND1; S1PR4; GABARAPL1; GADD45BB; IRS4
Phosphatidylinositol signaling system
IP6K2; PLCE1; TMEM55B; PLCB3; INPP5B; PIK3R1; DGKAA; CALM3B; PIK3CD; DGKD
Sphingolipid signaling pathway
PLCB4; PPP2R5E; CERS5; NRAS; LASS5; PPP2R2B; GAB2; SGMS1; MAP2K1; PLCB3
Phospholipase D signaling pathway
SYK; F2R; PDGFA; CYTH1; AGTR1A; PIK3CD; RRAS2; FYN; PIK3CA; AVPR1B
mTOR signaling pathway
HIF1AB; EIF4E2RS1; RPS6KB1B; RPS6KB2; PRKCBA; IGF1; RPS6KA2; RRAGCA; RRAGC; AKT3A
PIK-Akt signaling pathway
IFNA21; AKT2; FASLG; FGF2; LAMB3; FGF16; IFNA2; GNG8; GNB2; FGF7
AMPK signaling pathway
LEP; IRS1; PIK3CD; ADIPOR2; PRKAG2; PIK3R5; LEPR; RPS6KB1; PPP2R5D; CPT1B
Apoptosis
CAPN1A; DSG1; TNFRSF10A; PLECA; TNFRSFA; GZMF; PPP3R1; PRKACAA; CLSPN; PLEC
Adrenergic signaling in cardiomyocytes
CALML5; CACNA2D1A; TNNT2; CACNB3; PPP2R1A; PPP1CAA; ADCY3; TMEM8C; SCN4BA; CALM2
VEGF signaling pathway
PTGS2B; MAPK14A; HRASA; MAP2K2; NFATC2; PXN; RAC3; PTK2; CASP9; RAC3A
Osteoclast differentiation
PIK3CG; OSCAR; RELA; SIRP-BETA; TGFBR2; TNFSF11; NFKB2; IKBKB; MAPK3; LILRA1
Focal adhesion
RAC2; ROCK2B; PIK3CB; ITGA3; PXN; KDR; BIRC2; CAPN2L; MAPK8; CDC42L
Signaling pathways regulating pluripotency of stem cells
TCF3; BMPR1A; ID1; FZD1; SMAD2; MAPK1; SETDB1; MAPK11; INHBC; BMP4
Platelet activation
FERMT3; PIK3CA; MAPK3; ROCK1; TBXAS1; RAP1A; ROCK2; PLA2G4C; FCGR2A; PRKACA
Toll-like receptor signaling pathway
MAP2K4; PIK3R2; MAPK8B; RIPK1; MAP2K2A; IFNAR2; TLR2-2; PIK3R1; IFNA14; IFNA16
Jak-STAT signaling pathway
OSM; IFNGR2; IFNL3; IFNB; STAM2; RNF207B; SOCS3; IL10RA; SOCS4; CSH
Natural killer cell mediated cytotoxicity
VAV2; KIR3DL1; IFNA12; CD247; IFNA17; RAC3; TNFRSF10D; PRKCG; CD48; HLA-C
T cell receptor signaling pathway
HRAS; IL4; MAPK1; NFKBIA; NFATC2; PPP3CC; FOS; VAV3; GRAPA; IFNG
B cell receptor signaling pathway
PLEKHA1; SLA2; CD22; PTPN18; CRKL; GSK3B; NFKBIA; FCGR2B; MAP2K1; MAPK3
Fc epsilon RI signaling pathway
NRAS; PIK3R2; AKT1; PRKCA; FCER1G; PLCG1; MAP2K1; MAP2K3; PIK3R5; PDPK1
Fc gamma R-mediated phagocytosis
PLD2; RAC2; MARCKSL1; PPAP2C; ARF6; PLA2G6; RAF1; RAC1; PRKCE; VAV3
TNF signaling pathway
MAP3K7; IL1B; RPS6KA5; BCL3; PTGS2; TNFAIP3; PIK3CG; TRAF3; TNFRSF1B; FOS
Leukocyte transendothelial migration
CD99; MAPK12; PRKCG; ROCK1; ARHGAP35; ACTG1; MYL9; PRKCB; OCLN; RASSF5
Neurotrophin signaling pathway
CALM2; GSK3B; YWHAE; PLCG2; SH2B3; FASLG; CALM3; MAPK3; BAX; PTPN11
Cholinergic synapse
GNGT1; CAMK2B; ITPR3; GNAI3; PRKACB; GNG4; CHRM5; CHRM3; FOS; GNG12
Inflammatory mediator regulation of TRP channels
PRKCE; CYP2C55; PRKCH; F2RL1; PPP1CB; CYP2C39; PLCB3; PIK3R2; PIK3R5; PLA2G6
Regulation of actin cytoskeleton
PIP5K1AB; IQGAP3; SCIN; CDC42L; DIAPH3; ACTN3A; CYFIP2; PDGFRA; ROCK2B; RAC1B
Insulin signaling pathway
CALM1A; PIK3R1; AKT2L; CBLC; EIF4E2RS1; PPP1CB; PHKA1; CALM3B; PPP1R3CA; SOCS3
Progesterone-mediated oocyte maturation
IGF1; MAPK12A; PIK3R3A; AKT1; IGF1R; PRKACB; BRAF; IGF1RB; INSB; HSP90AA1.2
Estrogen signaling pathway
MAPK1; ITPR1; MMP2; CREB3L2; GNAS; HSPA2; OPRM1; GNAQ; SHC2; GNAI1
Prolactin signaling pathway
MAPK10; ELF5; GRB2; ESR2; FOS; SOCS5; CCND2; SOCS3; PIK3CB; MAPK1
Thyroid hormone signaling pathway
SLC2A1; MED13; NRAS; NOTCH3; AKT2; RAF1; EP300; PLCB2; TP53; RCAN2
Oxytocin signaling pathway
ITPR1; CAMK2A; PPP1CB; CCND1; FOS; MYLK4; CACNG6; PRKCA; ROCK1; NFATC3
Regulation of lipolysis in adipocytes
NPY; IRS1; PDE3B; GNAI1; PRKACB; PRKACG; AQP7; PIK3R5; Adcy4; INS2
Type II diabetes mellitus
PDX1; MAPK8; MAPK3; MTOR; ADIPOQ; PIK3R3; PIK3CG; IKBKB; PIK3R5; SOCS4
Insulin resistance
SLC27A4; PRKAG2A; RPS6KA1; PRKAB2; RPS6KA2; SOCS3B; PPP1R3B; ACACB; AKT1; SLC2A1A
Non-alcoholic fatty liver disease (NAFLD)
LEP; IL-8; NDUFB4; TNF; PIK3R1; NDUFB10; PIK3CB; EIF2AK3; NDUFB11; ADIPOR1
Aldosterone-regulated sodium reabsorption
PRKCA; HSD11B2; SCNN1G; KRAS; PIK3CD; KCNJ1; INSR; PIK3R1; ATP1A3; ATP1B1
Carbohydrate digestion and absorption
ATP1A2; TAS1R2; G6PC3; AMY2A4; SLC37A4; G6PC2; ATP1A1; PIK3R5; HK2; ATP1A4
Bacterial invasion of epithelial cells
CLTC; DNM2; SEPT2; PIK3R2; ARPC5L; CTNNA3; CBL; ARPC2; ARPC3; DNM1
Chagas disease (American trypanosomiasis)
TGFBR2; TGFB2; CCL3L3; SMAD3; GNAO1; CFLAR; CXCL8; TNFRSF1A; PIK3R3; Fasl
Toxoplasmosis
GNAO1; IRAK4; NOS2; SOCS1; HLA-DOB; IRGM; TGFB2; LY96; IL10RB; MAP2K6
Amoebiasis
LAMB3; GNAQ; TLR2; C8A; PIK3R2; LAMA5; COL4A4; PLCB1; IL1B; IL1B2
Hepatitis C
MAPK8; TYK2; IKBKB; CLDN17; PPARA; IRF9; OAS1; GSK3B; IFNA7; MAPK10
Hepatitis B
IL-8; PIK3CD; CASP12; NFKB1; MAP2K1; TICAM2; DDX3X; OSTN; MAPK1; TRP53
Measles
IFNA2; EIF3H; IL2RB; IFNA16; CD209C; TRAF6; IFNB1; HSPA2; OAS1A; CD3E; CD3D
Influenza A
IFNA17; PIK3R1; TYK2; IFNAR2; IL-8; TLR3; TRIM25; MAPK12; MAPK11; IL8L1
HTLV-I infection
IL1R1; PPP3CC; KAT2B; FZD8; FZD6; RAN; PPP3R1; WNT8A; MAPK8; WNT6
Epstein-Barr virus infection
CD19; HLA-F; BCL2; DDX58; PSMC2; IFNG; PLCG2; TBP; NFKBIE; HLA-E
Pathways in cancer
Fgf15; FGF4; FGF19; PIK3R1; GSK3B; EPAS1; GNG12; FOS; BCL2; WNT16
Viral carcinogenesis
ACTN2; TRADD; ACTN4; HIST1H2BN; MAPK1; PIK3R5; PIK3CA; HIST1H2BQ; HIST1H2BA; HIST1H2BE
Proteoglycans in cancer
MTOR; WNT8B; PIK3CB; WNT2B; FLNA; AKT1; PTPN11; STAT3; Fasl; TFAP4
Colorectal cancer
TCF7L2; AXIN2; PIK3R5; PIK3R2; RALGDS; MAPK10; BRAF; BCL2; AKT1; CYCS
Renal cell carcinoma
PIK3R5; TGFA; PIK3CD; HRAS; SOS1; PIK3CB; AHA-1; TGFB2; MAP2K1; TCEB2
Pancreatic cancer
PIK3R1; RALB; TGFA; TP53; ARHGEF6; MAPK1; MAPK3; TGFB2; MAPK8; RAF1
Endometrial cancer
TCF7; KRAS; CASP9; MAPK3; MAP2K2; ILK; PIK3CD; ARAF; FOXO3; PIK3CG
Glioma
PLCG1; BRAF; PDGFA; TRP53; CALML3; AKT2; TGFA; ARAF; MAPK3; SHC3
Prostate cancer
CCNE2; CREB3L1; RAF1; IKBKG; FGFR1; BRAF; ACTL6B; TP53; MAP2K2; SPRY1
Melanoma
MAP2K2; PIK3CG; TP53; FGF1; FGF21; IGF1R; FGF8; PTEN; FGF14; IGF1
Chronic myeloid leukemia
BAD; STAT5B; TGFB3; PIK3CG; CBL; ABL1; TGFB2; PTPN11; CTBP1; CRKL
Acute myeloid leukemia
RARA; SPI1; SOS1; LEF1; TCF7; CCNA1; PIK3R3; PIK3CA; GRB2; IKBKG
Small cell lung cancer
TRAF2; CKS2; CCNE2; PIK3CB; NFKBIA; RARB; BCL2; PIK3R1; LAMA3; ITGA6
Non-small cell lung cancer
MAPK1; TP53; HRAS; PIK3CG; MAPK3; NRAS; MAP2K1; SOS1; PIK3R3; TRP53
Central carbon metabolism in cancer
PDGFRA; PGAM2; PDHA1; MAP2K1; GLS2; PIK3CG; PIK3CD; SLC2A2; SLC1A5; HK1
Choline metabolism in cancer
WASF3; DGKA; AKT1; DGKD; PRKCA; PIP5K1A; DGKQ; PLD2; PIK3R5; PIK3CA

Protein Function

PIK3R3 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R3 itself. We selected most functions PIK3R3 had, and list some proteins which have the same functions with PIK3R3. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3R3; PIK3CA; PIK3C3; PIK3C2B; PIK3CB; PIK3C2A; PIK3CD; ATM; PIK3C2G; PIK3CG
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein CCKBR; PIK3R1; PIK3R2; PIK3R3B; PIK3R6; PIK3R5; PIK3R3; PIK3R3A
Function protein binding
Related Protein PSMD11; PQBP1; CCL3; KLHL20; ZNF624; DLG4; Il4ra; STXBP1; GAL; BCL11A

Interacting Protein

PIK3R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R3.
EGFR; PIK3CA; PTK2; SRC; CRK; PLEKHS1