pik3r3
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
  • Background
  • Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme that in humans is encoded by the PIK3R3 gene.
  • Synonyms
  • PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphatidylinositol 3-kinase regulatory subunit gamma; p55; p55PIK; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; 100% homology to SWISS-PROT Q92569; PI3-kinase regulatory su
Cat.#:PIK3R3-4464RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIK3R3 Protein
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Cat.#:PIK3R3-3436RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R3 Protein, His-tagged
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Cat.#:PIK3R3-3184HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3R3 293 Cell Lysate
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Involved Pathway

PIK3R3 involved in several pathways and played different roles in them. We selected most pathways PIK3R3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
RPS6KB1; MAPK10; MAP2K4B; PIK3CB; MAP2K2; NRAS; PTK2; AKT2; AKT3A; ARAF
Ras signaling pathway
PLA2G4C; FGF10; PLA2G4A; FGF19; RIN1; Pdgfa&Pdgfb; RGL1; IKBKB; IGF1; HTR7
Rap signaling pathway
FLT1; APBB1IP; PIK3R5; RAC2; KIT; CDH1; F2R; MAPK13; MAP2K6; Itgam&Itgb2
cGMP-PKG signaling pathway
PPP3R1; SLC25A6; PPP3R2; SRF; CREB3L1; GTF2IRD1; MAPK1; TRPC6; CALML3; ITPR1
cAMP signaling pathway
HCAR3; MAPK10; MC2R; Adcy4; PRKACB; LIPE; MAPK1; GNAI3; ROCK1; GLI3
Chemokine signaling pathway
ITK; ARRB1; GNG10; GRK7; CXCL2; PIK3R5; PLCB1; GNB4; CCR7; CCL23
HIF- signaling pathway
IFNGR2; NPPA; STAT3; PIK3R5; EP300; NFKB1; CUL2; NOS2; CAMK2B; PIK3CD
FoxO signaling pathway
MDM2; PCK1; FBXO32; PTENB; HRASA; PIK3R3; GADD45B; CCNB1; EP300; SLC2A4
Phosphatidylinositol signaling system
PIP4K2AA; PIK3R3A; INPP5D; PLCD3; INPP5J; MTMR7; CALM2; SYNJ2; MTMR8; MTMR6
Sphingolipid signaling pathway
PIK3CD; PTEN; PPP2R5C; PDPK1; LASS1; MAPK8; SGMS2; PRKCB; FCER1G; GAB2
Phospholipase D signaling pathway
PLA2G4F; SHC1; AGPAT3; SOS1; GNAS; CYTH2; GRM2; PLA2G4D; PLCG2; PLD1
mTOR signaling pathway
VEGFAA; VEGFAB; PRKAA2; INS; RPTOR; PIK3R1; PTENA; CAB39; EIF4E2; ULK3
PIK-Akt signaling pathway
TRP53; FGF17; CREB3L2; TCL1B1; PRL; IFNA5; INS1; LPAR4; RXRA; LAMB1
AMPK signaling pathway
PIK3R2; PFKFB2; CREB3L3; PIK3CB; PPP2R2B; PDPK1; PPP2R2A; CPT1C; PFKL; PRKAB2
Apoptosis
TICAM1; AKT1; BCL2L11; DCC; H1F0; IL1A; IRF1B; HIST1H1C; BIRC7; IL3RA
Adrenergic signaling in cardiomyocytes
TPM2; CACNG7; PPP1CAB; SLC14A2; TNNC1B; CACNA2D2; PLCB3; CREB3L2; ADCY3; ADRB3A
VEGF signaling pathway
MAP2K1; MAPKAPK2; SPHK2; MAPK14A; PRKCBB; PRKCB; PIK3R5; VEGFAA; MAP2K2; SRC
Osteoclast differentiation
MAP3K7; CYLD; LILRA2; MAPK3; IFNAR2; FCGR3; FCGR1A; NOX3; PIK3R3; FHL2
Focal adhesion
RHOAB; VEGFAA; ACTN1; MYL9A; RAC3A; ITGB3; MAPK8; ITGA6B; AKT3A; PTK2AB
Signaling pathways regulating pluripotency of stem cells
NODAL; GRB2; ID3; MAPK13; PCGF1; MAPK12; ACVR2B; WNT7A; PIK3R3; AKT2
Platelet activation
FERMT3; FGA; PIK3R2; PLCB1; RAP1B; ARHGEF1; FGB; ITPR1; ITGB1; MYL12A
Toll-like receptor signaling pathway
IFNA5; TLR4BA; IRF5; MAPK12; MAPK1; PIK3R2; MAPK8; CXCL11; MYD88; AKT2
Jak-STAT signaling pathway
LEPB; IL20RA; IFNB1; IFNG; IL19; IL21R; PIK3R3A; CRFB16; PIK3CD; STAT5A
Natural killer cell mediated cytotoxicity
KLRA8; ULBP2; IFNA4; KIR2DS5; SHC3; HLA-C; IFNA17; TNFRSF10C; IFNAR2; PAK1
T cell receptor signaling pathway
NCK2; MAPK1; TEC; PPP3CA; MAPK11; MAP2K7; FYN; EVLB; PPP3R1; ZAP70
B cell receptor signaling pathway
cgr2b; CDK4; PPP3CB; PIK3R1; TTC6; MAPK1; MAP2K1; LAT2; IFITM1; BANK1
Fc epsilon RI signaling pathway
FYN; AKT1; PLA2G4C; AKT2; VAV3; IL5; PDPK1; MAPK11; PIK3CG; PLCG1
Fc gamma R-mediated phagocytosis
CFL2; AKT1; PRKCB; FCGR2B; PIK3R1; RAF1; PIK3CB; ARPC1A; PRKCD; HCK
TNF signaling pathway
PIK3CG; Ccl12; CXCL3; MLKL; CASP10; IKBKB; TRAF3; CREB5; MAPK9; MAP3K5
Leukocyte transendothelial migration
CLDN23; MSN; ACTN2; ITGB1; PIK3R2; NCF2; CLDN11; ITGB2L; PLCG1; ROCK1
Neurotrophin signaling pathway
MAP3K5; CAMK2A; SORT1; CAMK2D; PIK3CA; RPS6KA6; RAF1; NTRK3; MAGED1; PIK3R2
Cholinergic synapse
CHRM3; MAPK3; CHRNA7; CAMK2B; GNG10; KCNQ4; CHRNB4; CHRM1; PIK3R3; GNG7
Inflammatory mediator regulation of TRP channels
PRKCA; TRPV3; PTGER4; MAPK12; PLA2G4C; PRKACB; CAMK2G; ASIC1; PRKCQ; CALML3
Regulation of actin cytoskeleton
FGF8; FGF18A; WASLB; PPP1CA; RHOA; PIP5K1C; PIK3R3B; MYL1; FGF21; SLC9A1
Insulin signaling pathway
PPP1CBL; SOCS3B; PIK3R3A; FBP1; HRASA; PRKAR1AB; INPPL1A; PRKACG; SHC1; SOCS2
Progesterone-mediated oocyte maturation
AKT2L; CCNB2; MAPK8B; MAD2L2; MAPK12; BRAF; IGF1R; CPEB3; CDK1; CCNB3
Estrogen signaling pathway
CALM2; MMP2; SP1; SHC4; SRC; CREB3L1; PLCB2; PIK3CB; CALM3; CALM1
Prolactin signaling pathway
SHC1; MAPK13; SOCS3; PIK3CG; LHB; FOS; STAT3; SLC2A2; RELA; MAPK1
Thyroid hormone signaling pathway
NCOR1; MED4; ESR1; NCOA3; ATP1A3; HIF1A; PLCZ1; KRAS; AKT1; SLC16A2
Oxytocin signaling pathway
PLA2G4D; PPP1CB; PLA2G4A; CACNA2D2; CALM2; MYLK4; MYLK2; CACNA2D1; PPP3R1; CAMKK1
Regulation of lipolysis in adipocytes
INSR; NPY; AQP7; PTGS2; PRKG2; INS; AKT1; PTGS1; INS2; PIK3R1
Type II diabetes mellitus
PRKCE; CACNA1G; IRS2; MAPK9; PKM; IKBKB; HK3; HKDC1; PIK3R3; IRS1
Insulin resistance
RPS6KA3B; PRKCBA; CREB5; PIK3CD; GSK3AA; PIK3R3A; RPS6KB2; GSK3B; PRKCDA; FOXO1
Non-alcoholic fatty liver disease (NAFLD)
MAP3K11; GSK3A; EIF2AK3; GSK3B; COX7A1; IL6R; INS; DDIT3; UQCRC2; PIK3CD
Aldosterone-regulated sodium reabsorption
PIK3CG; INS1; KCNJ1; MAPK1; ATP1B1; FXYD2; PIK3CA; PIK3R5; IGF1; PDPK1
Carbohydrate digestion and absorption
PRKCB; PIK3R3; ATP1B3; SLC2A5; PLCB2; ATP1B4; AMY2A3; G6PC2; FXYD2; TAS1R2
Bacterial invasion of epithelial cells
DOCK1; CAV3; SHC3; SEPT12; PIK3R1; PTK2; ARPC2; CD2AP; RHOA; BCAR1
Chagas disease (American trypanosomiasis)
SMAD3; TRAF6; Fasl; Ccl12; TLR9; PPP2CB; Il2; PPP2CA; CD3D; PPP2R1A
Toxoplasmosis
H2-AA; HLA-DRB5; IL10RB; IFNGR2; HLA-DMB; TYK2; PPIF; AKT1; IL12B; PIK3R3
Amoebiasis
SERPINB6; RAB7; LAMC1; LAMB3; CXCL8; CXCL1; IL-8; LAMA2; IL6; ACTN2
Hepatitis C
MAVS; PIK3R3; CLDN3; PPP2R1B; MAPK12; OAS3; PIK3CD; PPP2R1A; GRB2; KRAS
Hepatitis B
HRAS; IL6; DDX3X; TGFB2; PRKCG; Ifna15; IKBKE; SMAD3; GRB2; PRKCA
Measles
CCNE1; TLR9; IFNA13; TNFSF10; TACR1; IFIH1; TNFAIP3; IRF7; PIK3CD; EIF3H
Influenza A
EIF2AK4; IRF9; ICAM1; H2-AA; IL8L2; OAS2; PRKCB; TNFRSF10B; MAPK3; MAP2K1
HTLV-I infection
BUB3; CDC23; WNT2; CALR; BUB1B; GPS2; FOS; SLC25A4; RAN; PPP3CA
Epstein-Barr virus infection
PIK3CB; POLR3H; PSMD12; PSMD8; MAPK13; TAB2; POLR2I; RAN; PTMA; NFKBIA
Pathways in cancer
MSH3; TPM3; CCNA1; TRAF6; FGFR2; TGFB2; PRKCA; HIF1A; GNG2; WNT3
Viral carcinogenesis
HIST1H2BJ; EGR3; YWHAH; VAC14; HIST1H4G; CCND2; HIST1H4A; HIST1H2BI; HIST1H2BD; GRB2
Proteoglycans in cancer
THBS1; SOS1; MDM2; PAK1; SMAD2; ANK1; FASLG; RPS6KB1; TLR2; CAMK2B
Colorectal cancer
MAPK1; TGFB1; AXIN1; AKT1; SMAD3; TGFBR1; MSH3; APC2; TP53; RAF1
Renal cell carcinoma
PAK7; PDGFB; NRAS; MAP2K2; KRAS; CUL2; PIK3R3; PAK2; MAP2K1; PAK6
Pancreatic cancer
IKBKG; BRAF; ARHGEF6; PIK3R5; NFKB1; RAF1; PIK3R1; PIK3CG; SMAD2; TRP53
Endometrial cancer
ELK1; PIK3CB; AKT1; PIK3CD; ARAF; TCF7; FOXO3; APC2; APC; HRAS
Glioma
PLCG2; SOS1; PIK3CG; TGFA; BRAF; NRAS; CAMK2B; PIK3R5; MAPK3; PIK3R2
Prostate cancer
PTEN; NKX3-1; BRAF; NRAS; PDGFA; MAP2K1; BCL2; MDM2; PDGFC; PIK3CD
Melanoma
PDGFRA; FGF8; FGF13; PIK3CA; ARAF; MAP2K2; MAP2K1; FGF19; FGFR1; PTEN
Chronic myeloid leukemia
PIK3R2; TGFBR1; RUNX1; PIK3CD; NFKB1; SHC4; TGFB3; SMAD4; PIK3CG; BCL2L1
Acute myeloid leukemia
PIK3CG; STAT5B; PPARD; AKT1; PIK3CB; RPS6KB1; KRAS; MTOR; ARAF; STAT5A
Small cell lung cancer
NFKB1; RXRG; TRAF1; PTK2; BIRC2; RB1; TRAF2; LAMA5; NFKBIA; PIAS2
Non-small cell lung cancer
PRKCG; CASP9; RAF1; AKT2; PRKCB; RXRB; ALK; PIK3CB; BRAF; PIK3R5
Central carbon metabolism in cancer
SLC2A2; PIK3CD; HK3; PDHA1; SLC2A1; PDGFRB; TP53; SLC7A5; AKT2; KIT
Choline metabolism in cancer
PDGFC; PIK3R1; SLC22A5; WASF1; SLC22A3; SLC22A1; DGKA; WAS; MAP2K2; PIK3R5

Protein Function

PIK3R3 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R3 itself. We selected most functions PIK3R3 had, and list some proteins which have the same functions with PIK3R3. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3CA; PIK3C2G; PIK3C3; ATM; PIK3CD; PIK3C2B; PIK3R3; PIK3C2A; PIK3CG; PIK3CB
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein CCKBR; PIK3R3B; PIK3R5; PIK3R2; PIK3R6; PIK3R1; PIK3R3; PIK3R3A
Function protein binding
Related Protein CST7; MRPL41; LGALS8; DNMBP; NOXA1; SCAMP5; PLSCR1; ARHGEF40; VANGL1; HTR6

Interacting Protein

PIK3R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R3.
EGFR; PIK3CA; PTK2; SRC; CRK; PLEKHS1