pik3r3
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
  • Background
  • Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme that in humans is encoded by the PIK3R3 gene.
  • Synonyms
  • PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphatidylinositol 3-kinase regulatory subunit gamma; p55; p55PIK; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; 100% homology to SWISS-PROT Q92569; PI3-kinase regulatory su
Cat.#:PIK3R3-4464RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIK3R3 Protein
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Cat.#:PIK3R3-3436RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R3 Protein, His-tagged
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Cat.#:PIK3R3-3184HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3R3 293 Cell Lysate
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Involved Pathway

PIK3R3 involved in several pathways and played different roles in them. We selected most pathways PIK3R3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
EREG; CAMK2G; ELK1; PRKCB; PIK3R5; EGFRA; ABL2; ABL1; RPS6KB1B; STAT5B
Ras signaling pathway
GRIN2A; FGF17; MET; VEGFC; FGF14; INSR; RASAL3; CALM2; PLCG1; PRKCA
Rap signaling pathway
FGFR2; MAPK13; FGF8; PARD6A; RAF1; ANGPT4; FGFR3; ACTB; FGF7; MAGI1
cGMP-PKG signaling pathway
GATA4; PDE5A; CALM3; MEF2D; CREB3L3; PIK3R1; SRF; ATP1B2; MYLK; ATP2B1
cAMP signaling pathway
ROCK2; PTCH1; PLD2; BRAF; PRKACG; VAV1; Adcy4; NPY1R; DRD1A; FSHB
Chemokine signaling pathway
AMCF-II; Ccl9; CRKL; CXCR6; SHC3; GNB2; GNGT1; GNG4; CXCR5; GRK4
HIF- signaling pathway
EIF4E1B; AKT1; SERPINE1; HIF1A; INS; CAMK2B; TFRC; Trf; SLC2A1; TCEB1
FoxO signaling pathway
INSRB; INSB; HOMER2; MAPK14B; KLF2; MAPK11; BNIP3; IGF1R; RAF1B; HOMER3
Phosphatidylinositol signaling system
PIK3R3B; IMPA1; DGKE; PIK3C3; PLCB4; PIK3R3; PPIP5K1; MTMR1B; IPMK; CALM3B
Sphingolipid signaling pathway
SGPP1; GNAI1; PRKCZ; PIK3R2; PPP2R5A; MAPK9; TP53; SGPL1; SMPD1; DEGS1
Phospholipase D signaling pathway
MAPK1; PTK2B; GNA12; PLA2G4D; Pdgfa&Pdgfb; PRKCA; NRAS; PLD2; PDGFRB; Kitl
mTOR signaling pathway
HIF1AB; PRKAA2; PRKAA1; PIK3R5; INSB; PRKCA; IGF1; EIF4E1C; EIF4BB; MAPK3
PIK-Akt signaling pathway
IFNA21; TP53; RAF1; BCL2L1; FGF1; FLT4; IFNAR2; TNN; PKN1; PPP2R5C
AMPK signaling pathway
IRS2; AKT1; PCK1; PFKFB1; PIK3CA; ADIPOR2; PPP2R3A; CD36; SREBF1; ADRa1A
Apoptosis
AKT2L; OCLN; BCAP31; TRP53; CASP7; ATM; STK24; BIRC2; HMGB2A; DIABLOA
Adrenergic signaling in cardiomyocytes
PRKACAB; AGTR1A; PPP1R1A; CACNG2A; CREB3L2; CREB3; ADRa1A; SCN5A; CACNB1; MYH15
VEGF signaling pathway
PIK3R3A; PLCG2; AKT2; PIK3R2; SHC2; PIK3CG; KRAS; MAPK11; MAPK12; HRAS
Osteoclast differentiation
MAP2K1; NOX1; MAP2K6; TREM2; PPARG; IL1A; CSF1; RELB; NCF2; SYK
Focal adhesion
FLT1; BAD; CAPN2L; VAV1; CCND2A; GRB2A; MAPK4; RAC3A; HGF; TLN1
Signaling pathways regulating pluripotency of stem cells
HAND1; WNT7A; REST; ACVR1C; BMI1; PCGF1; PCGF5; JARID2; WNT4; ID2
Platelet activation
PRKACB; ROCK1; AKT2; NOS3; GNAI2; RHOA; MYL12B; FGG; FERMT3; GNAS
Toll-like receptor signaling pathway
CCL5; MAP2K7; MAPK11; IFNA17; IFNPHI3; MAP2K3; TLR8; PIK3R1; LY96; IFNA8
Jak-STAT signaling pathway
AKT3A; IFNA6; IL19; IL2RA; IRX1; CSH1; GRB2B; CCND1; EPOR; IFNE
Natural killer cell mediated cytotoxicity
SHC3; IFNAR1; IFNA13; Ifna15; FCGR3; RAET1G; PIK3CA; Ifna11; FASLG; IFNAR2
T cell receptor signaling pathway
PTPRC; KRAS; DBNLB; MAPK12; CD40LG; PDCD1; MAPK3; PAK6; CD28; TEC
B cell receptor signaling pathway
HDAC5; CDK2; INPPL1; ITK; NRAS; PTPN6; NEDD9; MAPK3; GRB2; FCGR2B
Fc epsilon RI signaling pathway
FYN; PIK3CG; MAPK10; IL3; PIK3CD; BTK; PLA2G4D; PLA2G4F; FCER1A; VAV3
Fc gamma R-mediated phagocytosis
FCGR2A; ARF6; LIMK2; PIK3CG; PLA2G4F; VAV2; PAK1; PIK3R2; PRKCA; SYK
TNF signaling pathway
MAPK3; LIF; MAP3K7IP3; CASP7; TRAF3; MAP3K5; MAP2K3; PIK3CD; BAG4; PIK3CA
Leukocyte transendothelial migration
ICAM1; CLDN16; NIPAL1; CLDN10; PRKCA; ACTG1; VCL; ACTN1; RAP1B; GNAI3
Neurotrophin signaling pathway
NFKB1; PRKCD; BAD; IRAK4; TP73; ABL1; RPS6KA2; PLCG2; YWHAE; RHOA
Cholinergic synapse
CHRNB4; CAMK2A; CAMK4; GNAI1; PRKCB; GNAI2; PRKACA; GNAO1; AKR1C1; CAMK2G
Inflammatory mediator regulation of TRP channels
NTRK1; CALML3; PLA2G4D; PIK3CD; ASIC4; CYP2J6; CAMK2B; HTR2A; MAPK12; GNAS
Regulation of actin cytoskeleton
FGFR1A; F2; FGD1; PIK3R1; INS2; ARAF; VCLA; PDGFB; MAP2K2; PPP1CB
Insulin signaling pathway
CBLB; MAPK10; PRKAG2; FLOT2B; MAP2K1; RHOQ; RHEB; ACACB; PPP1R3B; PTPRF
Progesterone-mediated oocyte maturation
GNAI1; CPEB4; CCNB1; MAP2K1; GNAI2A; HSP90AB1; RPS6KAL; FZR1A; HSP90AA1; PPP1R2P9
Estrogen signaling pathway
PRKCD; PRKACB; HSPA2; ESR2; KCNJ6; PLCB3; MMP2; PRKACA; HSPA1A; HSPA6
Prolactin signaling pathway
SOCS7; PRL; NEK3; PIK3R3; FOS; PIK3R5; CCND1; SHC1; PRP2; SHC2
Thyroid hormone signaling pathway
NRAS; MAP2K1; NCOA1; HRAS; KRAS; PLCG1; FOXO1; PRKACA; SRC; TRP53
Oxytocin signaling pathway
PIK3CB; ITPR1; PRKACG; MYLK3; PRKAB2; NRAS; PRKAG3; CACNG1; SRC; PIK3CA
Regulation of lipolysis in adipocytes
PIK3CB; ABHD5; PRKACG; TSHR; IRS4; AKT1; PIK3R1; PIK3CG; LIPE; PDE3B
Type II diabetes mellitus
PIK3CD; MAPK9; PRKCE; PIK3CA; PIK3CG; IKBKB; PDX1; HK2; INSR; PIK3R5
Insulin resistance
CREB5; PPP2R4; MAPK8A; SLC2A4; PPP1R3CA; GFPT2; RPS6KB2; PYGM; PRKAG3; PRKCZ
Non-alcoholic fatty liver disease (NAFLD)
SDHD; EIF2AK3; NDUFB7; NDUFB2; CASP8; SDHC; ITCH; ADIPOR2; KCNA3; PIK3CD
Aldosterone-regulated sodium reabsorption
ATP1A4; PIK3R1; ATP1A3; PIK3CG; INS2; SGK1; NEDD4L; PIK3R5; ATP1B1; SCNN1B
Carbohydrate digestion and absorption
ATP1A1; AMY2B; SLC5A1; PIK3CG; AMY2A3; TAS1R2; HK1; PIK3R1; ATP1B4; SI
Bacterial invasion of epithelial cells
SHC1; ELMO2; CBLC; PIK3R1; DNM3; SEPT11; ACTB; WASL; SEPT6; ARPC3
Chagas disease (American trypanosomiasis)
RELA; PIK3CA; BDKRB2; Ccl12; CCL5; GNAS; CFLAR; IL12B; CCL3L1; C1QC
Toxoplasmosis
TLR2; HLA-DRB1; HLA-DMB; Toxoplasma Gondii Major Surface Antigen P30; HSPA2; PIK3CA; Toxoplasma Gondii Dense Granule Protein 7; HLA-DMA; HLA-DQA1; IL12A
Amoebiasis
COL4A6; C8B; FN1; PIK3R5; SERPINB9; PIK3CD; NFKB1; CTSG; PTK2; SERPINB1C
Hepatitis C
MAPK10; EIF2AK3; TNFRSF1A; NFKB1; TYK2; MAPK11; IFNAR1; IFNA2; IFNA21; CLDN2
Hepatitis B
MAPK8; TLR4; CREB5; CREB3L3; BAX; CCNE1; YWHAB; IFN-a; NFATC3; Casp3
Measles
IRAK4; OAS1A; TLR9; IL1B; CD209A; PIK3CB; MSN; IRAK1; CD46; IFNA17
Influenza A
HSPA1L; TNFRSF10B; HLA-DPB1; LOC100033925; TNFRSF1A; HLA-DQB1; HLA-DQA1; PIK3R2; NXF2; IL18
HTLV-I infection
TBP; FZD1; WNT3; CDC16; MAP2K4; RANBP3; CCND2; IL15; CCND1; EGR2
Epstein-Barr virus infection
MAP2K3; XPO1; SPI1; POLR1D; PSMC1; HLA-F; NFKBIB; MAP3K14; HSPA6; HLA-DRA
Pathways in cancer
GNA12; HDAC2; GNAI1; WNT7A; WNT4; FH; AKT2; LPAR2; ARHGEF1; FZD5
Viral carcinogenesis
POLB; TTC6; GTF2E1; HIST2H2BE; HIST1H4F; MAPK3; HIST1H4M; CCND3; LYN; HIST1H2BJ
Proteoglycans in cancer
TGFB2; HOXD10; MAP2K2; CAMK2G; FZD6; ERBB2; MAP2K1; SRC; WNT7A; PLCG2
Colorectal cancer
MSH2; BRAF; Casp3; RAC3; AKT1; MAPK9; BAX; MAPK10; PIK3R1; PIK3CA
Renal cell carcinoma
VEGFA; AHA-1; PDGFB; EP300; VHL; PIK3CA; ARAF; SLC2A1; KRAS; GRB2
Pancreatic cancer
PIK3R2; VEGFA; RAC1; SMAD2; PLD1; RALGDS; BAD; MAP2K1; PIK3R1; PIK3CD
Endometrial cancer
BRAF; TRP53; CASP9; CDH1; PIK3R5; PIK3CB; PIK3R2; MLH1; RAF1; SOS1
Glioma
CAMK2D; PDGFB; PDGFRA; PIK3CG; PDGFA; CALM1; MAPK3; SHC3; AKT1; TRP53
Prostate cancer
RB1; BRAF; FGFR2; NKX3-1; MTOR; PIK3R5; CCNE1; SPRY1; PDPK1; PIK3R2
Melanoma
FGF5; Pdgfa&Pdgfb; FGF2; MAPK1; FGF3; PIK3CB; PIK3CA; FGF11; HRAS; MAP2K2
Chronic myeloid leukemia
IKBKB; STAT5B; TRP53; NFKBIA; SMAD4; MAP2K2; RELA; SHC3; PIK3CG; TGFB2
Acute myeloid leukemia
PPARD; CCNA1; SOS1; PIK3R2; BRAF; TCF7; PIK3R1; PIK3CG; PIK3R3; PIK3CA
Small cell lung cancer
ITGA2; LAMB2; PTEN; PTK2; TRAF5; NFKB1; LAMB3; APAF1; PIK3R3; SKP2
Non-small cell lung cancer
ERBB2; RXRG; BAD; FHIT; STK4; RASSF1; GRB2; PLCG2; PIK3R5; TRP53
Central carbon metabolism in cancer
GLS2; NTRK1; PDK1; RET; PDHA2; SIRT3; HK2; LDHA; HKDC1; MAP2K2
Choline metabolism in cancer
DGKG; RALGDS; WASF3; SLC44A1; RPS6KB2; PLA2G4C; MAPK9; PIK3R5; PLA2G4F; MAP2K2

Protein Function

PIK3R3 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R3 itself. We selected most functions PIK3R3 had, and list some proteins which have the same functions with PIK3R3. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3C2G; PIK3C2A; PIK3CG; PIK3C3; PIK3CB; ATM; PIK3CA; PIK3R3; PIK3C2B; PIK3CD
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein PIK3R2; PIK3R6; PIK3R5; PIK3R3; CCKBR; PIK3R1; PIK3R3A; PIK3R3B
Function protein binding
Related Protein NDUFS1; ORC4L; TRIM10; CD33; ENTPD1; C16orf45; LDHAL6B; PRKCI; NME2; RAD54L

Interacting Protein

PIK3R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R3.
EGFR; PIK3CA; PTK2; SRC; CRK; PLEKHS1