PIKFYVE
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Official Full Name
phosphoinositide kinase, FYVE finger containing
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Overview
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
PIKFYVE; phosphoinositide kinase, FYVE finger containing; phosphatidylinositol 3 phosphate/phosphatidylinositol 5 kinase, type III , PIP5K3; 1-phosphatidylinositol 3-phosphate 5-kinase; KIAA0981; MGC40423; p235; PIP5K; PIPkin-III; type III PIP ki;
- Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293T
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- GST
- His
- His|T7
- Myc
- DDK
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | PIKFYVE-173H | Active Recombinant Human PIKFYVE protein, GST-tagged | Insect Cell | GST | ||
Human | PIKFYVE-120H | Recombinant Human PIKFYVE, GST-tagged | Sf9 Insect Cell | GST | ||
Human | PIKFYVE-359H | Recombinant Human PIKFYVE Protein, His-tagged | E.coli | His | ||
Human | PIKFYVE-1394H | Recombinant Human PIKFYVE Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Mouse | Pikfyve-1850M | Recombinant Mouse Pikfyve protein, His & T7-tagged | E.coli | His/T7 | Thr1680~Glu1931 (Accession # Q9Z1T6) | |
Mouse | Pikfyve-4867M | Recombinant Mouse Pikfyve Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Zebrafish | PIKFYVE-6776Z | Recombinant Zebrafish PIKFYVE | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- PIKFYVE Related Articles
PIKFYVE involved in several pathways and played different roles in them. We selected most pathways PIKFYVE participated on our site, such as Inositol phosphate metabolism, Phosphatidylinositol signaling system, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIKFYVE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Inositol phosphate metabolism | IMPA2;PLCB4;PIP5K1BB;INPP5K;PIP5K1AB;IMPAD1;MTMR7;PLD4;NUDT4 |
Phosphatidylinositol signaling system | PIP5K1C;PIK3R5;PIK3C2A;PTENA;PIK3C2B;INPP5D;CALM1B;PIK3CB;PLCB1 |
Phagosome | MHC2DCB;ITGA2;ITGB2;FCGR3A;BF2;HLA-DQA1;C1R;SEC22BA;DYNC1LI1 |
Regulation of actin cytoskeleton | ARPC4L;FGF1A;MRAS;ITGA3;FGF5;INSB;ITGAM;NCKAP1L;SCINLB |
PIKFYVE has several biochemical functions, for example, 1-phosphatidylinositol-3-phosphate 5-kinase activity, 1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIKFYVE itself. We selected most functions PIKFYVE had, and list some proteins which have the same functions with PIKFYVE. You can find most of the proteins on our site.
Function | Related Protein |
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1-phosphatidylinositol-3-phosphate 5-kinase activity | |
1-phosphatidylinositol-4-phosphate 5-kinase activity | PIP5K1C;PIKFYVE;PIP5K1A;PIP4K2B;PIP4K2C;PIP5K1B;PIP5KL1;PIP4K2A |
ATP binding | MOV10;ABCA8;PIP5K1B;EPHB3A;SLKA;PMS2;LATS1;EPHA5;PRPF4B |
metal ion binding | TRIM35;BRCC3;ZNF100;NT5DC1;ROCK2A;COL27A1A;CYP46A1.2;SNRNP48;SMYD1B |
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity | TENC1;SACM1LB;PXYLP1;SGPP2;PTPRQ;FIG4;NT5DC3;SACM1LA;SACM1L |
protein binding | PSMA1;FRS3;DMC1;EIF3J;CXorf41;PCNP;SND1;AGTR2;RHOA |
PIKFYVE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIKFYVE here. Most of them are supplied by our site. Hope this information will be useful for your research of PIKFYVE.
VAC14; Dlg4; 1C
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Write a reviewTheir ability to accommodate the requirements of large-scale experiments and guarantee a reliable supply streamlines my research operations, eliminating any concerns related to potential shortages.
I am confident that the protein will reliably perform in my assays, providing accurate and reproducible results.
the manufacturer's supply management capabilities assure a seamless and continuous provision of the PIKFYVE protein.
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